Glucocorticoid receptor activation is associated with increased resistance to heat‐induced hyperthermia and injury

Chen, Yifan; Yu, Tianzheng

doi:10.1111/apha.13015

Cited by 8 publications

(4 citation statements)

References 39 publications

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“…In addition, both the mitochondrial and nuclear GR levels were significantly increased in TA mice compared to control. Similar data were also obtained from TA and Cort-treated C2C12 mouse myoblasts which exhibit increased viability during heat exposure and increased mitochondrial and nuclear GR expression, further supporting the idea that GR activation in mitochondria is associated with increased resistance against heat-induced hyperthermia and injury [ 89 ]. Table 5 summarizes the association between mitochondrial GR and mitochondrial-related alterations in lung disease, hepatic inflammation, and hyperthermia.…”

Section: Mitochondrial Glucocorticoid Receptor and Thermoregulationsupporting

confidence: 76%

“…Evidence has shown that GR alongside with Mineralocorticoid Receptor (MR) can participate in the control of energy expenditure, through inhibition of uncoupling proteins —UCP1 and UCP3—which consist of specific mitochondrial proton transporters involved in thermoregulation and control of energy expenditure [ 88 ]. In vivo and in vitro studies by Chen et al, using thermal acclimation (TA)-exposed mice as well as TA and Cort-treated C2C12 mouse myoblast, investigated the association between GR and resistance to heat-induced hyperthermia and injury [ 89 ]. Their data revealed that heat tolerant and intolerant heat exposed mice—compared to mice not exposed to heat—exhibited reduced cytosolic levels of GR in the gastrocnemius muscles while tolerant mice exhibited elevated mitochondrial and nuclear GR.…”

Section: Mitochondrial Glucocorticoid Receptor and Thermoregulationmentioning

confidence: 99%

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Mitochondrial Glucocorticoid Receptors and Their Actions

Kokkinopoulou

Moutsatsou

2021

IJMS

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Mitochondria are membrane organelles present in almost all eukaryotic cells. In addition to their well-known role in energy production, mitochondria regulate central cellular processes, including calcium homeostasis, Reactive Oxygen Species (ROS) generation, cell death, thermogenesis, and biosynthesis of lipids, nucleic acids, and steroid hormones. Glucocorticoids (GCs) regulate the mitochondrially encoded oxidative phosphorylation gene expression and mitochondrial energy metabolism. The identification of Glucocorticoid Response Elements (GREs) in mitochondrial sequences and the detection of Glucocorticoid Receptor (GR) in mitochondria of different cell types gave support to hypothesis that mitochondrial GR directly regulates mitochondrial gene expression. Numerous studies have revealed changes in mitochondrial gene expression alongside with GR import/export in mitochondria, confirming the direct effects of GCs on mitochondrial genome. Further evidence has made clear that mitochondrial GR is involved in mitochondrial function and apoptosis-mediated processes, through interacting or altering the distribution of Bcl2 family members. Even though its exact translocation mechanisms remain unknown, data have shown that GR chaperones (Hsp70/90, Bag-1, FKBP51), the anti-apoptotic protein Bcl-2, the HDAC6- mediated deacetylation and the outer mitochondrial translocation complexes (Tom complexes) co-ordinate GR mitochondrial trafficking. A role of mitochondrial GR in stress and depression as well as in lung and hepatic inflammation has also been demonstrated.

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Section: Mitochondrial Glucocorticoid Receptor and Thermoregulationsupporting

confidence: 76%

Section: Mitochondrial Glucocorticoid Receptor and Thermoregulationmentioning

confidence: 99%

Mitochondrial Glucocorticoid Receptors and Their Actions

Kokkinopoulou

Moutsatsou

2021

IJMS

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“…Short incubation periods of 40 min at 42 °C (Vallanat et al, 2010) or three hours at 39.5 °C (Chen and Islam, 2016) seem most desirable for practical and animal welfare reasons, although also longer treatment regimens with exposure periods of 8–24 hours daily and recovery periods of between one day and six weeks were described (Houston et al, 2018). Body core temperature should be constantly monitored with implanted transponders or other temperature probes during heat exposure to terminate the experiment in case the body core temperature reaches 42.2 °C (Chen and Yu, 2017).…”

Section: Temperature Stressmentioning

confidence: 99%

Modelling physical resilience in ageing mice

Schosserer

Banks

Doğan

et al. 2019

Mechanisms of Ageing and Development

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Geroprotectors, a class of drugs targeting multiple deficits occurring with age, necessitate the development of new animal models to test their efficacy. The COST Action MouseAGE is a European network whose aim is to reach consensus on the translational path required for geroprotectors, interventions targeting the biology of ageing. In our previous work we identified frailty and loss of resilience as a potential target for geroprotectors. Frailty is the result of an accumulation of deficits, which occurs with age and reduces the ability to respond to adverse events (physical resilience). Modelling frailty and physical resilience in mice is challenging for many reasons. There is no consensus on the precise definition of frailty and resilience in patients or on how best to measure it. This makes it difficult to evaluate available mouse models. In addition, the characterization of those models is poor. Here we review potential models of physical resilience, focusing on those where there is some evidence that the administration of acute stressors requires integrative responses involving multiple tissues and where aged mice showed a delayed recovery or a worse outcome then young mice in response to the stressor. These models include sepsis, trauma, drug- and radiation exposure, kidney and brain ischemia, exposure to noise, heat and cold shock.

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“…Depending on this, corticosterone is used as stress biomarkers (Gong et al 2015;de Bruijn and Romero 2018). Glucocorticoid receptor overexpression enhances mice's ability to tolerate injury and hyperthermia-induced by heat stress (Chen and Yu 2018).…”

Section: Introductionmentioning

confidence: 99%