Glucocorticoid Regulates Interleukin-37 in Systemic Lupus Erythematosus

Song, Lijun; Qiu, Feng; Yong-sheng, Fan; Ding, Feng; Liu, Huaxiang; Shu, Qiang; Liu, Weiwei; Li, Xingfu

doi:10.1007/s10875-012-9791-z

Cited by 92 publications

(89 citation statements)

References 41 publications

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“…Our study revealed that levels of IL-37 were positively correlated with SLEDAI-2K score which came in agreement with a study done by Song et al (1), 2013. We also found that levels of IL-37 were positively correlated with duration between onset and diagnosis of the disease.…”

Section: Discussionsupporting

confidence: 93%

“…Our finding was close to the result of a study done by Song et al (1), 2013, where percentage of arthritis was 73.3% and higher than a study done by Abdwani et al (14), 2014, where percentage of arthritis was 62.96%.…”

Section: Discussionsupporting

confidence: 89%

“…It is evident that disturbances in the immune regulation mechanisms, such as imbalance of pro-inflammatory and anti-inflammatory cytokines, contribute to the development of SLE (1).…”

Section: Introductionmentioning

confidence: 99%

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Level of Interleukin 37 (IL-37) in Children with Systemic Lupus Erythematosus and Its Correlation with Disease Activity

et al. 2017

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Background: Systemic lupus erythematosus (SLE) is an autoimmune disorder caused by auto-antibodies against self-antigens. Interleukin 37 (IL-37) is a member of IL-1family, and it is a key cytokine in regulating inflammation. We aimed to detect the level of IL-37 in SLE patients and to correlate it with disease activity. Methods: A cross-sectional study included fifty children with SLE following up at the pediatric rheumatology clinic in specialized children's hospital, Cairo University and chosen randomly; aged up to 16 years and thirty, apparently healthy children with matched age and gender, were assigned as the control group. In all cases and controls, full history was taken, full physical examination performed and laboratory investigations including level of IL-37 were done. Results: Levels of IL-37 in the 50 cases with SLE were higher than in the 30 controls with statistically significant difference (P = 0.028). Level of IL-37 was higher in active cases than in inactive cases but without statistically significant difference (P = 0.58). Level of IL-37 level in cases with mild activity was lower than in cases with moderate or severe activity but without statistically significant difference (P = 0.23). Conclusions: level of IL-37 was higher in our SLE patients than in controls and it is higher in active cases than inactive cases. IL-37 is correlated positively with duration between onset and diagnosis of disease and SLEDAI-2K activity score.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 89%

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Level of Interleukin 37 (IL-37) in Children with Systemic Lupus Erythematosus and Its Correlation with Disease Activity

et al. 2017

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“…Recent studies revealed that IL37 has a strong anti-inflammatory effect during an innate immune response as well as in the development of inflammation (Nold et al 2010, Banchereau et al 2012. Published literature suggests that IL37 is expressed in various normal tissues, tumors (Pan et al 2001, Kumar et al 2002 and by human peripheral blood mononuclear cells under inflammatory conditions, such as systemic lupus erythematosus (SLE) (Song et al 2013), Behcet's disease (BD) (Ye et al 2014) and acute coronary syndrome (Ji et al 2014). Genetic variants in inflammation-related cytokine genes may have the potential to alter the regulation of transcript production or function.…”

Section: Discussionmentioning

confidence: 99%

Polymorphism of IL37 gene as a protective factor for autoimmune thyroid disease

Ni¹,

Meng²,

Song³

et al. 2015

Journal of Molecular Endocrinology

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Autoimmune thyroid disease (AITD) comprises Graves' disease (GD) and Hashimoto's thyroiditis (HT). IL37 has been recently proved to be a natural suppressor for innate immunity and acquired immunity. Therefore, this study was conducted to identify the association of IL37 genetic polymorphisms with AITD in Chinese Han population. Polymorphisms of rs3811046/rs3811047/rs2723176/rs272186 in the IL37 gene were assessed in a case-control study comprising 701 GD patients, 301 HT patients and 939 controls. Genetic variants were genotyped by multiplex polymerase chain reaction and ligase detection reaction. The frequencies of the minor allele A of rs2723176 and A of rs2723186 were significantly lower in the GD patients than in the controls (PZ0.014, ORZ0.774; PZ0.014, ORZ0.777). After gender stratification, the rs3811046 G allele and the rs3811047/rs2723186 A allele were both significantly associated with a decreased risk of GD in female patients (PZ0.030, ORZ0.777; PZ0.023, ORZ0.774; PZ0.029, ORZ0.761). However, none of the four single nucleotide polymorphisms of IL37 gene showed any significant association with HT. Moreover, haplotype analysis revealed the GCG haplotype conferred increased risk for GD as a whole and in female GD patients (ORZ1.213; ORZ1.320). The ACG haplotype was associated with an increased risk of HT as a whole (ORZ1.567) and in male GD patients (ORZ1.820). In contrast, the AAA haplotype showed a protective role for GD as a whole (ORZ0.760) and in female GD patients (ORZ0.765). Our study strongly supports that the IL37 gene variants are associated with the susceptibility to AITD.

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“…Wan et al reported that decreased IL-37 expression leads to the increased secretion of pro-inflammatory cytokines including IL-16 and IL-1β in degenerative intervertebraldisc, which suggests a function for IL-37 in delaying the progression of intervertebral disc degeneration (57). It has also been shown that IL-37 expression is significantly higher in the plasma of patients with SLE and that IL-37 suppresses the secretion of pro-inflammatory cytokines in PBMCs of SLE patients (60,73,74). IL-37b expression levels in serum and nasal lavage are significantly increased in children with allergic rhinitis (AR) (14).…”

Section: Chronic Inflammatory and Autoimmune Disordersmentioning

confidence: 99%

Interleukin-37: A crucial cytokine with multiple roles in disease and potentially clinical therapy (Review)

et al. 2018

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Abstract. Interleukin (IL)-37, a new IL-1 family member, has received increasing attention in recent years. In the past decade, it has been determined that IL-37 is expressed in various normal cells and tissues and is regulated by inflammatory stimuli and pro-cytokines via different signal transduction pathways. Recently, it has been found that IL-37 is expressed in a variety of cancers, chronic inflammatory and autoimmune disorders, and exerts anti-inflammatory effects. Moreover, a growing body of literature demonstrates that IL-37 plays a vital role in inhibiting both innate and adaptive immune responses as well as inflammatory reactions. In addition, IL-37 may prove to be a new and potentially useful target for effective cytokine therapy. Further evidence is needed to clarify in more detail the effects of IL-37 in experimental and clinical studies. Based on an extensive summary of published data, the aim of this review is to outline the current knowledge of IL-37, including the location, structure, expression, regulation and function, as well as the potential clinical applications of this cytokine.

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Glucocorticoid Regulates Interleukin-37 in Systemic Lupus Erythematosus

Cited by 92 publications

References 41 publications

Level of Interleukin 37 (IL-37) in Children with Systemic Lupus Erythematosus and Its Correlation with Disease Activity

Level of Interleukin 37 (IL-37) in Children with Systemic Lupus Erythematosus and Its Correlation with Disease Activity

Polymorphism of IL37 gene as a protective factor for autoimmune thyroid disease

Interleukin-37: A crucial cytokine with multiple roles in disease and potentially clinical therapy (Review)

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