Glucocorticoid toxicity

Drug Defaulting in a General Practice

“…Supporting evidence for the advantages of a once-daily schedule is found in the model for patients having long-term treatment; though dosage did not correlate significantly with compliance, it none the less made a substantial contribution to the regression in a direction favouring once-daily dosages. Other work suggests that a once-daily dose schedule is adhered to more faithfully than a divided-dose schedule (Rose, 1941 ;Nugent et al, 1965;Oakley, 1967) and is more popular (Ziehm and Likos, 1966).…”

Single daily dose corticosteroid treatment. Effect on adrenal function and therapeutic efficacy in various diseases.

“…Studies of single daily dose treatment have previously been made by Nugent, Ward, Macdiarmid, McCall, Baukol, and Tyler (1965) who compared the effect of taking prednisolone once a day with the effect of twice the dose on alternate days. The therapeutic and toxic effects were similar in the two groups.…”