Glucocorticoids drive human CD8+ T cell differentiation towards a phenotype with high IL-10 and reduced IL-4, IL-5 and IL-13 production

Richards, David F.; Fernández, María del Camino García; Caulfield, J. B. D.; Hawrylowicz, Catherine

doi:10.1002/1521-4141(2000)30:8<2344::aid-immu2344>3.0.co;2-7

Cited by 116 publications

(67 citation statements)

References 27 publications

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“…Associations between inflammatory markers, the immune system, and depression have also been described (Miller et al 2009;Miller 2010). In animals, the elevation of APPs by transportation and weaning stress has been reported (Richards et al 2000;Arthington et al 2003). Weaning stress may induce an APR through increased cortisol production and modulation of inflammatory cytokines (Kim et al 2011).…”

Section: Biological Function and Molecular Pathways Correlated With Csupporting

confidence: 93%

Elucidating Molecular Networks That Either Affect or Respond to Plasma Cortisol Concentration in Target Tissues of Liver and Muscle

Ponsuksili

Muráni

et al. 2012

Genetics

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Cortisol is a steroid hormone with important roles in regulating immune and metabolic functions and organismal responses to external stimuli are mediated by the glucocorticoid system. Dysregulation of the afferent and efferent axis of glucocorticoid signaling have adverse effects on growth, health status, and well-being. Glucocorticoid secretion and signaling show large interindividual variation that has a considerable genetic component; however, little is known about the underlying genetic variants. Here, we used trait-correlated expression analysis, screening for expression quantitative trait loci (eQTL), genome-wide association (GWA) studies, and causality modeling to identify candidate genes in porcine liver and muscle that affect or respond to plasma cortisol levels. Through trait-correlated expression, we characterized transcript activities in many biological functions in liver and muscle. Candidates from the list of trait-correlated expressed genes were narrowed using only those genes with an eQTL, and these were further prioritized by determining whether their expression was predicted to be related to variation in plasma cortisol levels. Using network edge orienting (NEO), a causality modeling algorithm, 26 of 990 candidates in liver were predicted to affect and 70 to respond to plasma cortisol levels. Of 593 candidates in muscle that were correlated with cortisol levels and were regulated by eQTL, 2 and 25 were predicted as effective and responsive, respectively, to plasma cortisol levels. Comprehensive data integration has helped to elucidate the complex molecular networks contributing to cortisol levels and thus its subsequent metabolic effects. The discrimination of up-and downstream effects of transcripts affecting or responding to plasma cortisol concentrations improves the understanding of the biology of complex traits related to growth, health, and well-being. C ORTISOL, a steroid hormone released in response to stress and a low level of blood glucocorticoids, acts to increase blood sugar through gluconeogenesis; suppress the immune system; and aid in fat, protein, and carbohydrate metabolism. Produced in the adrenal cortex under the control of the hypothalamic-pituitary-adrenal axis and the sympatho-adrenomedullar (SAM) system, cortisol is most important during times of stress, when it modulates many of the acute responses to illness and "resets" metabolism in favor of providing substrates for oxidative metabolism (Andrews and Walker 1999). Stress factors can unbalance metabolic homeostasis, directing the demand for nutrients and energy for essential physiological processes away from growth (Heetkamp et al. 1995). Individual cortisol concentration is variable and depends on sensitivity to stress, which is highly genetically determined (e.g., heritability estimates of 0.40-0.70 in pigs) (Geverink et al. 2002; Kadarmideen and Janss 2009). According to the function of cortisol in the maintenance of basal and stress-related homeostasis the adrenocortical steroidogenesis is sensitive to exo...

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Section: Biological Function and Molecular Pathways Correlated With Csupporting

confidence: 93%

Elucidating Molecular Networks That Either Affect or Respond to Plasma Cortisol Concentration in Target Tissues of Liver and Muscle

Ponsuksili

Muráni

et al. 2012

Genetics

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“…However, not all cytokines are suppressed by glucocorticoids. IL-10 secretion is increased by glucocorticoids (Blotta et al, 1997;Richards et al, 2001), whereas others (i.e. IL-6) act synergistically with glucocorticoids (Wiegers et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Effects of dietary nucleotide supplementation on growth performance and hormonal and immune responses of piglets

Superchi

Saleri

Borghetti

et al. 2012

Animal

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The effects of dietary nucleotide supplementation from 9 days of age until the end of post-weaning on piglets hormonal and immune responses and on growth performance were investigated. During lactation (days 9 to 21) and post-weaning (days 22 to 55) 10 [HBI Fomeva11 3 (Large White 3 Landrace)] litters (n 5 108 piglets) had ad libitum access to two standard diets, both supplemented with 0% (T0 group) or 0.1% (T1 group) of yeast extract nucleotides. BW of piglets at days 21 (P , 0.10), 35 and 55 (P , 0.05) was greater in T1 compared with T0. Feed intake was not different between groups (P . 0.05). Cortisol content was lower in T1 than in T0 at days 28 and 35 (P , 0.05), whereas growth hormone was lower at day 35 (P , 0.05). Levels of IGF-1 were similar across groups (P . 0.05). Nucleotide-supplemented diets increased lymphocyte subpopulation CD42CD81 high at days 21 and 35 (P , 0.05), whereas CD41CD82 cells were higher in T1 than in T0 at day 21 (P , 0.05). Peripheral blood mononuclear cells cytokine expression was influenced by dietary nucleotide supplementation. At weaning, interleukin (IL)-6 and IL-1b expression was lower (P , 0.05) in T1 compared with T0, whereas the expression of interferon (IFN)-g and IL-10 was higher (P , 0.05). At day 28, piglets in T1 showed higher values of tumor necrosis factor (TNF)-a expression than T0 and lower values of IL-10 expression (P , 0.05). Dietary nucleotide supplementation had a suppressive effect on IL-6 and IL-10 expression (P , 0.05) at day 35. On the contrary, the expression of IFN-g, TNF-a and IL-1b was enhanced (P , 0.05). In conclusion, these results suggest that starting a dietary nucleotide supplementation before weaning can improve the adaptive capabilities of weaned piglets to the stressors, enhancing the growth performance.

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“…Another possibility is that GCR action leads to enhanced serine-phosphorylation As discussed above GC can also induce IL-10 in monocytes (Mozo et al, 2004), in macrophages (Frankenberger et al, 2005) and in T cells (Barrat et al, 2002;Richards et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

“…According to in-vitro studies GC can induce IL-10 in monocytes (Mozo et al, 2004) and macrophages (Frankenberger et al, 2005). Furthermore, GC treatment will induce IL-10 in T cells in therapeutic settings (Karagiannidis et al, 2004) and in in-vitro culture (Barrat et al, 2002;Richards et al, 2000).…”

Section: Role Of Stat3 In Glucocorticoid-induced Expression Of the Humentioning

confidence: 99%

Role of STAT3 in glucocorticoid-induced expression of the human IL-10 gene

Unterberger

Staples

Smallie³

et al. 2008

Molecular Immunology

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Glucocorticoids drive human CD8+ T cell differentiation towards a phenotype with high IL-10 and reduced IL-4, IL-5 and IL-13 production

Cited by 116 publications

References 27 publications

Elucidating Molecular Networks That Either Affect or Respond to Plasma Cortisol Concentration in Target Tissues of Liver and Muscle

Elucidating Molecular Networks That Either Affect or Respond to Plasma Cortisol Concentration in Target Tissues of Liver and Muscle

Effects of dietary nucleotide supplementation on growth performance and hormonal and immune responses of piglets

Role of STAT3 in glucocorticoid-induced expression of the human IL-10 gene

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