Glucógeno hepático en dengue severo: análisis histopatológico

Illustrated histopathological features of fatal dengue cases in Colombia

“…The histopathological analyses of fatal cases indicate that the liver and spleen are the most affected organs during dengue virus infection. In the liver, it is common to find small necrotic foci, microvesicular steatosis, hyperplasia and apoptosis of Kupffer cells, lymphocyte infiltration in the portal tract and Councilman bodies (necrotic foci, acidophilic bodies, and pyknotic nuclei) 13 - 16 , although intranuclear glycogen can be occasionally found 17 .…”