Glucomannan, a promising polysaccharide for biopharmaceutical purposes

Alonso-Sande, M.; Teijeiro‐Osorio, Desirée; Remuñán‐López, Carmen; Alonso, María José

doi:10.1016/j.ejpb.2008.02.005

Cited by 201 publications

(101 citation statements)

References 98 publications

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“…According to the literature [16,43], the increasing of the mechanical resistance is caused by higher amounts of β-sheet structure, which is more stable. In the case of KGM, ethanol assisted in the deacetylation of the molecule [16], facilitating the formation of hydrogen bonds and hydrophobic interactions between chains composing a gel network structure [7,42]. This result was consistent with those obtained by ATR-FTIR, TGA and XDR analyses.…”

Section: Thermal Characterizationsupporting

confidence: 81%

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Synthesis and Properties of Silk Fibroin/Konjac Glucomannan Blend Beads

et al. 2018

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Silk fibroin (SF) and konjac glucomannan (KGM) are promising materials in the biomedical field due to their low toxicity, biocompatibility, biodegradability and low immune response. Beads of these natural polymers are interesting scaffolds for biomedical applications, but their fabrication is a challenge due to their low stability and the necessary adaptation of their chemical and mechanical properties to be successfully applied. In that sense, this study aimed to synthesize a blend of silk fibroin and konjac glucomannan (SF/KGM) in the form of porous beads obtained through dripping into liquid nitrogen, with a post-treatment using ethanol. Intermolecular hydrogen bonds promoted the integration of SF and KGM. Treated beads showed higher porous size, crystallinity, and stability than untreated beads. Characterization analyses by Fourier-transform infrared spectroscopy (FTIR), thermogravimetric (TGA), and X-ray diffraction (XDR) evidenced that ethanol treatment allows a conformational transition from silk I to silk II in SF and an increase in the KGM deacetylation. Those chemical changes significantly enhanced the mechanical resistance of SF/KGM beads in comparison to pure SF and KGM beads. Moreover, samples showed cytocompatibility with HaCaT and BALB/c 3T3 cells.

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Section: Thermal Characterizationsupporting

confidence: 81%

“…Over the last years, it was mainly used as a bioactive polymer. KGM, combined with other polymers, can be used as a controlled delivery system for drugs, and antimicrobial materials [7,8].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Properties of Silk Fibroin/Konjac Glucomannan Blend Beads

et al. 2018

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“…The plant based polymers have been studied various research group for their application in different pharmaceutical dosage forms like matrix controlled system, film coating agents, buccal films, microspheres, nanoparticles, viscous liquid formulations like ophthalmic solutions, suspensions, implants and their efficacy have been reported (Pandey, Khuller, 2004;Chamarthy, Pinal, 2008;Alonso-Sande et al, 2009). These have also been utilized as viscosity enhancers, stabilizers, disintegrants, solubilisers, emulsifiers, suspending agents, gelling agents and bioadhesives, binders in the above mentioned dosage forms (Guo,et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

Physico-chemical and structural characterization of mucilage isolated from seeds of Diospyros melonoxylon Roxb.

Singh¹,

Bothara²

2014

Braz. J. Pharm. Sci.

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Mucilage was isolated from the seeds of Diospyros melonoxylonRoxb., a plant growing naturally in the forests of India. Various physico-chemical methods like particle analysis, scanning electron microscopy, differential scanning calorimetry, differential thermal analysis, thermogravimetry analysis, molecular weight by gel permeation chromatography, rheometry, elemental analysis, x-ray diffraction spectrometry, zeta potential, fourier transform infrared spectroscopy, 1D(1H and 13C) (NMR) have been employed to characterize this gum in the present study. Particle analyses suggest that mucilage had particle size in nanometer. SEM analysis suggested that the mucilage had irregular particle size. The glass transition temperature of the gum observed was 78 °C and 74 °C by DSC and DTA respectively. The Thermogravimetry analysis suggested that mucilage had good thermal stability with two stage decomposition. The molecular weight of mucilage was determined to be 8760, by gel permeation chromatography, while the viscosity of mucilage was observed to be 219.1 cP. The XRD pattern of the mucilage indicated a complete amorphous nature. Elemental analysis of the gum revealed specific contents of carbon, hydrogen, nitrogen and sulfur. The major functional groups identified from FT-IR spectrum include 3441 cm-1 (-OH), 1632 cm-1 (-COO-), 1414 cm-1 (-COO-) and 1219 cm-1 (-CH3CO). Analysis of mucilage by paper chromatography and 1D NMR indicated the presence of sugars.

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“…Endo β-mannanase is an important enzyme in degrading polysaccharide due to its ability to catalyze random hydrolysis of β-D-1,4-mannopyranosyl linkage (Alonso-Sande et al, 2009). Hydrolysis on this linkage from a glucomannan backbone will produce oligosaccharides in the form of mannobiose and mannotriose (Addemark et al, 1998).…”

Section: Analyzing Mannooligosaccharides By Using Tlc and Hplcmentioning

confidence: 99%

Enzymatic Hydrolysis of Porang by Streptomyces violascens BF 3.10 Mannanase for the Production of Mannooligosaccharides

Safitri

Meryandini

Yopi

2014

Med Pet

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Porang (Amorphophallus muelleriBlumeo C dengan aktivitas enzim sebesar 16.38 U/mL dan stabil pada suhu 4 °C selama 48 jam. Selama 5 jam waktu hidrolisis, reaksi dengan konsentrasi substrat 0,25%, 0,5%, dan 1% glukomanan porang yang dilarutkan dalam 10 mL enzim menghasilkan manooligosakarida dengan derajat polimerisasi 2-3. Visualisasi produk hidrolisis mengggunakan metode thin layer chromatography (TLC) dan high performance liquid chromatography (HPLC) menunjukkan bahwa jenis manooligosakarida yang dihasilkan adalah glukosa, manobiosa, manotriosa, dan manotetrosa. Derajat polimerisasi dan gula-gula sederhana yang terbentuk menunjukkan bahwa mananase S. violascens bekerja secara aktif mengatalisis reaksi hidrolisis ikatan 1,4-β-D-manosida dari rantai utama β-1,4-mannan sehingga menghasilkan gula-gula sederhana manooligosakarida.

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Glucomannan, a promising polysaccharide for biopharmaceutical purposes

Cited by 201 publications

References 98 publications

Synthesis and Properties of Silk Fibroin/Konjac Glucomannan Blend Beads

Synthesis and Properties of Silk Fibroin/Konjac Glucomannan Blend Beads

Physico-chemical and structural characterization of mucilage isolated from seeds of Diospyros melonoxylon Roxb.

Enzymatic Hydrolysis of Porang by Streptomyces violascens BF 3.10 Mannanase for the Production of Mannooligosaccharides

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