Glucosamine sulfate compared to ibuprofen in osteoarthritis of the knee

Müller-Fassbender, H; Bach, Gerhard; Haase, Wolfgang; Rovati, Lucio C.; Setnikar, I

doi:10.1016/s1063-4584(05)80007-x

Cited by 192 publications

(100 citation statements)

References 33 publications

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“…GS is a popular nutritional supplement in relieving the symptoms of osteoarthritis [41][42][43][44] but is not used clinically for the treatment of ocular diseases. TA is a synthetic corticosteroid and has been used to control intraocular inflammatory conditions since 1974.…”

Section: Resultsmentioning

confidence: 99%

Subretinal fluid from rhegmatogenous retinal detachment and blood induces the expression of ICAM-1 in the human retinal pigment epithelium (ARPE-19) in vitro

Chen

et al. 2009

Eye

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Purpose To evaluate the effect of subretinal fluid (SRF) from rhegmatogenous retinal detachment (RRD) and blood on the expression of intercellular adhesion molecule-1 (ICAM-1) in the retinal pigment epithelium. Methods The study included 22 patients who had experienced RRD within 1 month before the study and 14 patients with macular holes or pucker. SRF was collected during surgery to repair RRD and the vitreous was collected during vitrectomy. The SRF was cocultured with ARPE-19 cells with and without glucosamine sulphate (GS) and triamcinolone acetonide (TA). Blood from peripheral veins and blood components (red blood cells, platelet-poor plasma, and platelet-rich plasma) were also cocultured with ARPE-19 cells. Vitreous samples were cocultured with ARPE-19 cells in the control. The expression of ICAM-1 was detected and quantified by using flow cytometry. Results The expression of ICAM-1 in RPE cells was significantly higher (Po0.05) after 24-h incubation of 40% SRF with ARPE-19 cells. In addition, the expression of ICAM-1 in retinal pigment epithelium (RPE) cells significantly increased (Po0.01) when cocultured with blood and blood components. However, there were no differences (P40.05) in ICAM-1 expression when RPE cells were cocultured with or without GS or TA.Conclusions SRF and blood enhanced the expression of ICAM-1 in RPE cells in this study and the increased expression of ICAM-1 by SRF is not inhibited by GS or TA.

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Section: Resultsmentioning

confidence: 99%

Subretinal fluid from rhegmatogenous retinal detachment and blood induces the expression of ICAM-1 in the human retinal pigment epithelium (ARPE-19) in vitro

Chen

et al. 2009

Eye

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“…При этом выраженность терапевтического эффекта (ES) для хондроитина сульфата (ХС) и ГС составляла соответствен-но 0,78 и 0,44. В двух рандомизированных контролируе-мых исследованиях сравнивался эффект ГС и ибупрофена [20,33]. Первое исследование показало, что через 8 недель ибупрофен эффективнее уменьшал болевой син-дром, однако к 8-й неделе преимущество было на сторо-не ГС [33].…”

Section: рисунок 2 роль глюкозамина в синтезе гиалуроновой кислоты рunclassified

“…Первое исследование показало, что через 8 недель ибупрофен эффективнее уменьшал болевой син-дром, однако к 8-й неделе преимущество было на сторо-не ГС [33]. Второе исследование, охватившее 4 недели лечения, продемонстрировало более быстрое действие ибупрофена, но к 4-й неделе уменьшение боли и функци-ональной подвижности суставов было одинаковым в обеих группах [20]. У 98 пациентов старших возрастных групп с ОА коленных суставов среднетяжелого и тяжелого течения на протяжении двухмесячного периода не уда-лось продемострировать статистически достоверных раз-личий между ГС и плацебо по влиянию на болевой син-дром и функциональную подвижность суставов [16].…”

Section: рисунок 2 роль глюкозамина в синтезе гиалуроновой кислоты рunclassified

Topical Issues of Osteoarthritis Treatment in Clinical Practice

Пешехонова¹,

Peshekhonov²,

Красюков³

2017

Med. sov.

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“…Meta-analysis, 16,26 systematic reviews 33 and double-blinded randomized clinical trials 6,12,18,20,22,24 show positive results in cases of osteoarthrosis of joints, both in improving symptoms and function, when treating with chondroitin and/or glucosamine. However, other RCTs showed that these therapies involving dietary supplements have not obtained significant results or more effective than placebo.…”

Section: E4mentioning

confidence: 99%

Use of chondroitin sulphate and glucosamine sulphate in degenerative changes in TMJ: a systematic review

Machado¹,

Machado²,

Cunali

2012

Dental Press J. Orthod.

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Introduction: Degenerative changes in Temporomandibular Joint (TMJ) have increased in prevalence and severity over the years. Within this context, it's necessary to obtain safe and effective therapies for control and management of the patient in cases of osteoarthritis and osteoarthrosis of the TMJ. Therapeutic options range from intra-articular infiltration protocols, occlusal splints, pharmacological therapies and physiotherapy and educational measures. The alternative treatment with structure-modifying agents, like as chondroitin and glucosamine sulphates, showed promising results, and especially safety. Thus, through a systematic literature review, this study aimed to analyze and discuss effectiveness and safety of chondroitin and glucosamine in degenerative changes of the TMJ.Methods: Survey in research bases MEDLINE, Cochrane, EMBASE, Pubmed, Lilacs and BBO, between the years of 1966 and January 2009, with focus in randomized clinical trial (RCTs) and quasi-randomized clinical trials, systematic reviews and meta-analysis. Results:After application of the inclusion criteria 2 articles were selected, both randomized controlled double-blind clinical trials, which evaluated the effectiveness of chondroitin and glucosamine in degenerative changes of the TMJ. Conclusions:There is the necessity of further RCT, with representative samples and long follow-up time, to obtainment more precise cause-effect relationships and to achieve an effective and objective protocol involving chondroitin and glucosamine in cases of degenerative changes of the TMJ. Introdução: as alterações degenerativas da Articulação Temporomandibular (ATM) têm aumentado em prevalência e em severidade ao longo dos anos. Dentro desse contexto, surge a necessidade de se obter terapêuticas efetivas e seguras para o controle e o manejo do paciente em situações de osteoartrite e osteoartrose da ATM. As opções terapêuticas variam desde protocolos de infiltrações articulares, dispositivos interoclusais, terapias farmacológicas e medidas fisioterápicas e educacionais. A alternativa de tratamento com agentes modificadores de estrutura -tais como o sulfato de condroitina e o sulfato de glicosamina -apresenta resultados promissores e, principalmente, seguros. KeywordsObjetivo: através de uma revisão sistemática da literatura, este trabalho teve como objetivo analisar e discutir a efetividade e a segurança da condroitina e da glicosamina nas alterações degenerativas da ATM.Métodos: levantamento nas bases de dados MEDLINE, Cochrane, Embase, PubMed, LILACS e BBO, no período compreendido entre 1966 e 2009, com enfoque em estudos clínicos randomizados (RCTs) e quase-randomizados, revisões sistemáticas e meta-análises.Resultados: após a aplicação dos critérios de inclusão, chegou-se a dois artigos (estudos clínicos randomizados controlados e duplo-cegos), que avaliaram a efetividade da condroitina e da glicosamina nas alterações degenerativas da ATM.Conclusão: existe a necessidade da realização de novos RCTs -com amostras representativas e tempo de acompanhament...

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Glucosamine sulfate compared to ibuprofen in osteoarthritis of the knee

Cited by 192 publications

References 33 publications

Subretinal fluid from rhegmatogenous retinal detachment and blood induces the expression of ICAM-1 in the human retinal pigment epithelium (ARPE-19) in vitro

Subretinal fluid from rhegmatogenous retinal detachment and blood induces the expression of ICAM-1 in the human retinal pigment epithelium (ARPE-19) in vitro

Topical Issues of Osteoarthritis Treatment in Clinical Practice

Use of chondroitin sulphate and glucosamine sulphate in degenerative changes in TMJ: a systematic review

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