Glucose biosensors based on Michael addition crosslinked poly(ethylene glycol) hydrogels with chemo-optical sensing microdomains

Williams, Tyrell J.; Jeevaraathinam, Ananthakrishnan S.; Jivan, Faraz; Baldock, Victoria; Kim, Paul; McShane, Michael J.; Alge, Daniel L.

doi:10.1039/d2tb02339c

Cited by 17 publications

(9 citation statements)

References 53 publications

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“…5 , it can be seen that all four groups of hydrogel samples reached the swelling equilibrium within 120 min, and their equilibrium swelling degrees were 6.35, 6.57, 7.59, and 10.15, respectively, and the four groups of hydrogel samples had high equilibrium swelling degrees. 35 The equilibrium swelling of the PEG/P(U-AM-ChCl) composite hydrogel gradually increased with the increase of PEG content, and the equilibrium swelling of the LP4 hydrogel was maximum when the content of PEG reached 1.0 wt%. This was attributed to the fact that PEG, as a macromolecule polymer, could extend the reticular structure of the hydrogel and form pores in the hydrogel network.…”

Section: Resultsmentioning

confidence: 91%

Preparation of PEG/P(U-AM-ChCl) composite hydrogels using ternary DES light polymerization and their properties

Li,

Liu,

Zhou

et al. 2024

RSC Adv.

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Section: Resultsmentioning

confidence: 91%

Preparation of PEG/P(U-AM-ChCl) composite hydrogels using ternary DES light polymerization and their properties

Li,

Liu,

Zhou

et al. 2024

RSC Adv.

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“…A classical approach for this method uses a cross-linker, a molecule that links the polymer chains to form the 3D matrix. Some examples of cross-linkers are glutaraldehyde, 140 ethylene glycol, 141 and citric acid. 142 In this method, the mechanical resistance of hydrogels increases substantially when compared to physical methods due to the more stable interaction between the polymeric chains.…”

Section: Preparation Of Gel Polymermentioning

confidence: 99%

Functional Gel-Based Electrochemical Energy Storage

Ruthes,

Arnold,

Prenger

et al. 2024

Chem. Mater.

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“…The samples were then dried (25 °C, 50% humidity) until constant weight, and the dry weight (W d ) was recorded. As previously reported (Williams et al, 2013), the water content was calculated according to the following formula:…”

Section: Water Content Evaluationmentioning

confidence: 99%

Release of delta-9-tetrahydrocannabinol from polyvinyl alcohol hydrogels and its safe interaction with human skin fibroblasts

Cui,

Zhang,

Rodrigue

et al. 2024

Front. Drug Deliv.

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This study aimed to design a THC-rich hydrogel to deliver cannabis derivatives topically. We developed hydrogels using polyvinyl alcohol (PVA) mixed with propylene glycol (PG), vegetable glycerin (VG), or both to facilitate the dissolution of delta-9-tetrahydrocannabinol (THC). The hydrogels showed a brown color, confirming the presence of the cannabinoid. They exhibit a porous structure and better mechanical properties than PVA alone. Indeed, the hydrogel containing PG, VG, or both showed elastic deformation behaviors with lower water content. FTIR analysis demonstrated the presence of THC with two specific peaks at 1,575 and 1,619 cm−1, confirming the presence of THC in the hydrogels. Human dermal fibroblast cultures onto the surface of all hydrogels confirmed the safety of the THC-rich hydrogel as the cell adhesion was comparable to the control (no THC). Furthermore, cells adhering to the hydrogels could proliferate, showing increased cell viability at 48 and 72 h, with a higher proliferation obtained with the THC-rich PVA-PG-VG hydrogels. Such cell behavior could be due to the release of the THC in the culture medium, as demonstrated by ultra-high performance liquid chromatography (UPLC), showing the presence of THC in the culture medium, ranging from 203 to 290 μg after 24 h of incubation of the hydrogels containing PG and VG or both. In comparison, the released THC from the PVA hydrogel was higher, reaching 852 μg. It is interesting to note that the THC release at 24, 48, and 72 h was slower with the hydrogels containing PG, VG, and both, compared to PVA alone. Overall, the present study has designed safe THC-rich PVA-PG-VG hydrogels as a functional delivery system for the topical use of cannabinoids to control tissue diseases, such as inflammation.

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Glucose biosensors based on Michael addition crosslinked poly(ethylene glycol) hydrogels with chemo-optical sensing microdomains

Abstract: Continuous glucose monitoring (CGM) devices have the potential to lead to better disease management and improved outcomes in patients with diabetes. Chemo-optical glucose sensors offer a promising, accurate, long-term alternative...

Cited by 17 publications

References 53 publications

Preparation of PEG/P(U-AM-ChCl) composite hydrogels using ternary DES light polymerization and their properties

Preparation of PEG/P(U-AM-ChCl) composite hydrogels using ternary DES light polymerization and their properties

Functional Gel-Based Electrochemical Energy Storage

Release of delta-9-tetrahydrocannabinol from polyvinyl alcohol hydrogels and its safe interaction with human skin fibroblasts

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