2006
DOI: 10.1097/01.med.0000200525.26578.72
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Glucose-dependent insulinotropic polypeptide – beyond the enteroinsular axis?

Abstract: Purpose of reviewGlucose-dependent insulinotropic polypeptide (GIP) plays an important role in the enteroinsular axis, stimulating insulin secretion. In addition, it has extrapancreatic actions, which may have pathophysiological relevance. This review highlights recent findings with regard to GIP's actions both within the enteroinsular axis and beyond it, and discusses evidence for the therapeutic potential of GIP receptor agonists and antagonists for the treatment of type 2 diabetes mellitus and possibly obes… Show more

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