Glucose kinase alone cannot be responsible for carbon source regulation in Streptomyces peucetius var. caesius

Ramos, Itzel; Guzmán, Silvia Irene Verdugo; Escalante, Laura; Imriskova, Iveta; Rodríguez‐Sanoja, Romina; Sánchez, Sergio; Langley, Elizabeth

doi:10.1016/j.resmic.2004.01.004

Cited by 29 publications

(36 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although the main uptake system for glucose in S. coelicolor is GlcP, a non-PTS permease of the major facilitator superfamily (911), CCR by glucose was observed (21,217,530,912). Glucose kinase (443,911) and the accumulation of glycolytic intermediates (694) are implicated in mediating the effect. Although S. coelicolor contains EI, HPr, EIIA Glc (designated EIIA crr ), and EIIBC Glc homologs as well as other sugar-specific EII complexes, PTS proteins do not seem to be involved in CRR in this high-GϩC gram-positive organism (58,629).…”

Section: Regulation By Eiia Glc -Like Proteinsmentioning

confidence: 99%

How Phosphotransferase System-Related Protein Phosphorylation Regulates Carbohydrate Metabolism in Bacteria

Deutscher

Francke

Postma

2006

Microbiol Mol Biol Rev

1,203

769

View full text Add to dashboard Cite

SUMMARY The phosphoenolpyruvate(PEP):carbohydrate phosphotransferase system (PTS) is found only in bacteria, where it catalyzes the transport and phosphorylation of numerous monosaccharides, disaccharides, amino sugars, polyols, and other sugar derivatives. To carry out its catalytic function in sugar transport and phosphorylation, the PTS uses PEP as an energy source and phosphoryl donor. The phosphoryl group of PEP is usually transferred via four distinct proteins (domains) to the transported sugar bound to the respective membrane component(s) (EIIC and EIID) of the PTS. The organization of the PTS as a four-step phosphoryl transfer system, in which all P derivatives exhibit similar energy (phosphorylation occurs at histidyl or cysteyl residues), is surprising, as a single protein (or domain) coupling energy transfer and sugar phosphorylation would be sufficient for PTS function. A possible explanation for the complexity of the PTS was provided by the discovery that the PTS also carries out numerous regulatory functions. Depending on their phosphorylation state, the four proteins (domains) forming the PTS phosphorylation cascade (EI, HPr, EIIA, and EIIB) can phosphorylate or interact with numerous non-PTS proteins and thereby regulate their activity. In addition, in certain bacteria, one of the PTS components (HPr) is phosphorylated by ATP at a seryl residue, which increases the complexity of PTS-mediated regulation. In this review, we try to summarize the known protein phosphorylation-related regulatory functions of the PTS. As we shall see, the PTS regulation network not only controls carbohydrate uptake and metabolism but also interferes with the utilization of nitrogen and phosphorus and the virulence of certain pathogens.

show abstract

Section: Regulation By Eiia Glc -Like Proteinsmentioning

confidence: 99%

How Phosphotransferase System-Related Protein Phosphorylation Regulates Carbohydrate Metabolism in Bacteria

Deutscher

Francke

Postma

2006

Microbiol Mol Biol Rev

1,203

769

View full text Add to dashboard Cite

show abstract

“…High concentrations of sugar elicit CCR over the use of alternative carbon sources and the synthesis of several secondary metabolites. Glucose repression in S. coelicolor operates at the transcriptional level to repress enzymes involved in the use of glycerol, arabinose, fructose and galactose 122 and this effect seems to be due to either intermediates of carbohydrate catabolism, for example, fructose 1,6-diphosphate and glucose 6-phosphate 123,124 or enzymes of the glucose catabolic pathway, such as glucose kinase. [125][126][127][128] In this regard, it has been reported that mutants of S. coelicolor resistant to the nonutilizable glucose analog, 2-deoxyglucose (DOG), appear to be generally deficient in glucose repression.…”

Section: Streptomycesmentioning

confidence: 99%

“…123 However, a direct effect of SCO2127 on the activation of Glk or GlcP cannot be discarded. In this regard, the apparent binding of Glk to the major glucose transport system of S. coelicolor (GlcP) reported by van Wezel et al 134 might be mediated by SCO2127, increasing the efficiency of glucose metabolism.…”

Section: Streptomycesmentioning

confidence: 99%

Carbon source regulation of antibiotic production

et al. 2010

Self Cite

View full text Add to dashboard Cite

“…Ruiz et al (2010) menyatakan bahwa pada kapang A. chrysogenum mempunyai kecenderungan terjadi mekanisme penghambatan produksi sefalosporin oleh sumber karbon yang berlebih. Hal ini disebabkan asetil-koA yang dihasilkan dalam siklus Krebs ketika jumlah carbon mencapai jumlah tertentu menghasilkan korepresor untuk menginaktifkan gen CreA yang merupakan penghasil enzim asetiltransferase sehingga tidak dapat ditrasnkripsi (Ramos et al 2004). …”

Section: Jenis Dan Konsentrasi Sumber Karbonunclassified

PENINGKATAN PRODUKSI SEFALOSPORIN C DARI <i>Acremonium chrysogenum</i> CB2/11/1.10.6 DENGAN OPTIMASI MEDIA MENGGUNAKAN METODE RESPON PERMUKAAN

Prabandari

Hidayati

Dewi

et al. 2017

J Bioteknol Biosains Indones

View full text Add to dashboard Cite

Cephalosporin is a β-lactam antibiotic produced by Keywords:Carbon, cephalosporin C, cultivation medium, nitrogen, A. chrysogenum ABSTRAK Sefalosporin C adalah golongan antibiotik β-lactam yang dihasilkan Acremonium chrysogenum melalui fermentasi cair. Komponen yang sangat berpengaruh terhadap produksi sefalosporin C adalah sumber karbon dan nitrogen. Penelitian ini bertujuan mendapatkan komposisi media terbaik untuk produksi sefalosporin C. Optimasi dilakukan menggunakan metode respon permukaan. Hasil menunjukkan bahwa molases 70 g/L adalah sumber karbon terbaik dan kombinasi corn steep liquor, urea dan ammonium sulfat adalah sumber nitrogen terbaik. DL-methionin, sumber karbon, dan nitrogen berpengaruh nyata terhadap produksi sefalosporin C. Optimasi menggunakan model matematika menunjukkan produksi sefalosporin C tertinggi (3876 mg/L) yang diperoleh dengan komposisi media 68,28 g/L molases, 71,61 g/L nitrogen, dan 0,4 g/L DL-methionin. Verfikasi di laboratorium menggunakan komposisi media yang sama menghasilkan sefalosporin C sebesar 3696 mg/L, berbeda 4,65% dibanding dengan hasil optimasi matematis. Optimasi media mampu meningkatkan produksi sefalosprin C sebesar 1,48 kali dibanding media yang digunakan sebelumnya, dimana maksimal hanya menghasilkan 2487 mg/L.

show abstract

Glucose kinase alone cannot be responsible for carbon source regulation in Streptomyces peucetius var. caesius

Cited by 29 publications

References 36 publications

How Phosphotransferase System-Related Protein Phosphorylation Regulates Carbohydrate Metabolism in Bacteria

How Phosphotransferase System-Related Protein Phosphorylation Regulates Carbohydrate Metabolism in Bacteria

Carbon source regulation of antibiotic production

PENINGKATAN PRODUKSI SEFALOSPORIN C DARI <i>Acremonium chrysogenum</i> CB2/11/1.10.6 DENGAN OPTIMASI MEDIA MENGGUNAKAN METODE RESPON PERMUKAAN

Contact Info

Product

Resources

About