Glucose modulates event-related potential components of recollection and familiarity in healthy adolescents

Smith, Michael A.; Riby, Leigh M.; Sünram-Lea, Sandra I.; Eekelen, Anke van; Foster, Jonathan

doi:10.1007/s00213-009-1509-4

Cited by 27 publications

(34 citation statements)

References 59 publications

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“…The finding of a lowered Sensitivity Index (SI) with glucose in comparison to placebo is in contrast to previous research by both Sünram-Lea et al [27] and Scholey et al [28] who reported a treatment effect in favour of glucose, and is also in contrast to the finding of no effect by Smith et al [32]. This finding is difficult to reconcile with current theories regarding the glucose-facilitatory effect.…”

Section: Discussioncontrasting

confidence: 91%

“…In contrast to the LP effect, the FN400 peaks earlier in the 300-500 ms latency range suggesting faster retrieval mechanisms and is maximal over midfrontal sites [30,31]. In a recent study using healthy adolescents, the hippocampal theory of glucose facilitation was brought into question when Smith et al [32] reported that glucose ingestion was associated with enhancement of both the LP effect as well as the frontal FN400 effect.…”

Section: Introductionmentioning

confidence: 99%

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Hippocampal involvement in glucose facilitation of recognition memory: Event-related potential components in a dual-task paradigm

Scholey

Camfield

Macpherson

et al. 2015

NUA

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Con and Riby, Leigh (2015) Hippocampal involvement in glucose facilitation of recognition memory: Event-related potential components in a dual-task paradigm. Nutrition and Aging, 3 (1 Northumbria University has developed Northumbria Research Link (NRL) to enable users to access the University's research output. Copyright © and moral rights for items on NRL are retained by the individual author(s) and/or other copyright owners. Single copies of full items can be reproduced, displayed or performed, and given to third parties in any format or medium for personal research or study, educational, or not-for-profit purposes without prior permission or charge, provided the authors, title and full bibliographic details are given, as well as a hyperlink and/or URL to the original metadata page. The content must not be changed in any way. Full items must not be sold commercially in any format or medium without formal permission of the copyright holder. The full policy is available online: http://nrl.northumbria.ac.uk/policies.html This document may differ from the final, published version of the research and has been made available online in accordance with publisher policies. To read and/or cite from the published version of the research, please visit the publisher's website (a subscription may be required.) Nutrition and Aging 3 (2015) METHODS:In this double-blind placebo-controlled cross-over study, 12 older participants (mean age = 69.33 ± 1.69 years) completed the remember-know paradigm both with and without a concurrent tracking task while recording event-related potentials (ERPs). RESULTS: Counter to predictions, glucose reduced overall accuracy. No treatment effects were found for proportion of Remember, Know and Guess responses, although there was a trend towards greater accuracy for 'Remember' responses following glucose. There was weak evidence for dissociation of drink effects on tracking with glucose being associated with preferential allocation of resources to 'Remember' over 'Know' responses. At P3 and F3 electrode sites, a significantly greater left parietal (LP) recollection effect and greater FN400 effect respectively were found for glucose. CONCLUSIONS: These findings do not support task effort modulation of the memory-enhancing effects of glucose. There was evidence of a greater glucose facilitatory effect for hippocampus-mediated LP recollection.

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Section: Discussioncontrasting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Hippocampal involvement in glucose facilitation of recognition memory: Event-related potential components in a dual-task paradigm

Scholey

Camfield

Macpherson

et al. 2015

NUA

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“…Subsequent to ingestion of a standardised oral glucose 22 tolerance test (OGTT) preparatory breakfast and 150 g glucose, improved performance was observed in this study in healthy adolescent participants for recall of low-and high-imagery paired associates, relative to a fasting control condition (Lapp, 1981). Recent findings from our laboratory have also observed an improvement in verbal episodic memory performance, under conditions of divided attention, in healthy adolescents, subsequent to glucose ingestion (Smith and Foster, 2008;Smith et al, in press;Smith et al, 2009). In one of these studies, further analyses suggested that glucose most reliably modulates memory in individuals with relatively higher trait anxiety (Smith et al, in press).…”

Section: Glucose Modulation Of Memory In Childrensupporting

confidence: 61%

“…P3b is known to be dependent on the hippocampus, whereas the P2 and P3a components are not, providing further evidence for the hippocampus hypothesis. By contrast, a further recent study from our laboratory (Smith et al, 2009) has suggested that glucose ingestion enhances ERP components of recollection (left parietal old/new effect) and familiarity (FN400) in adolescents. Given that recollection, but not familiarity, is thought to be supported by the hippocampus, this study suggests that glucose may target more global brain regions in modulating memory (Smith et al, 2009).…”

Section: The 'Hippocampus Hypothesis'mentioning

confidence: 67%

“…By contrast, a further recent study from our laboratory (Smith et al, 2009) has suggested that glucose ingestion enhances ERP components of recollection (left parietal old/new effect) and familiarity (FN400) in adolescents. Given that recollection, but not familiarity, is thought to be supported by the hippocampus, this study suggests that glucose may target more global brain regions in modulating memory (Smith et al, 2009). In addition, this finding is further supported by previous studies in which a benefit of glucose ingestion was observed for tasks that are not directly subserved by the hippocampus (e.g.…”

Section: The 'Hippocampus Hypothesis'mentioning

confidence: 67%

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Glucose enhancement of human memory: A comprehensive research review of the glucose memory facilitation effect

Smith

Riby

Eekelen

et al. 2011

Neuroscience & Biobehavioral Reviews

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123

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The brain relies upon glucose as its primary fuel. In recent years, a rich literature has developed from both human and animal studies indicating that increases in circulating blood glucose can facilitate cognitive functioning. This phenomenon has been termed the 'glucose memory facilitation effect'. The purpose of this review is to discuss a number of salient studies which have investigated the influence of glucose ingestion on neurocognitive performance in individuals with a) compromised neurocognitive capacity, as well as b) normally functioning individuals (with a focus on research conducted with human participants). The proposed neurocognitive mechanisms purported to underlie the modulatory effect of glucose on neurocognitive performance will also be considered. Many theories have focussed upon the hippocampus, given that this brain region is heavily implicated in learning and memory. Further, it will be suggested that glucose is a possible mechanism underlying the phenomenon that enhanced memory performance is typically observed for emotionally laden stimuli.

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Carbohydrate and Protein Metabolism: Influences on Cognition and Alzheimer's Disease

Fernando

Gupta

Jayasena

et al. 2019

Neurodegeneration and Alzheimer's Disease

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Glucose modulates event-related potential components of recollection and familiarity in healthy adolescents

Cited by 27 publications

References 59 publications

Hippocampal involvement in glucose facilitation of recognition memory: Event-related potential components in a dual-task paradigm

Hippocampal involvement in glucose facilitation of recognition memory: Event-related potential components in a dual-task paradigm

Glucose enhancement of human memory: A comprehensive research review of the glucose memory facilitation effect

Carbohydrate and Protein Metabolism: Influences on Cognition and Alzheimer's Disease

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