Glucose-sensitive capsules based on hydrogen-bonded (polyvinylpyrrolidone / phenylboronic –modified alginate) system

Belbekhouche, Sabrina; Charaabi, Saddam; Carbonnier, Benjamin

doi:10.1016/j.colsurfb.2019.02.006

Cited by 19 publications

(18 citation statements)

References 30 publications

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“…165,167,176,177 Then, the selective removal of the templates induces the obtention of the capsule. Thus, this is a simple and a straightforward approach which could be applied to a wide range of materials, including organic or inorganic templates as calcium carbonate particles [178][179][180] vesicle/liposome 181 liquid template [182][183][184][185][186] metal oxide nanoparticles 187 or gold nanoparticles as templates. [188][189][190][191][192][193] Recently, we have investigated the elaboration of nanocapsules based on N6L 194 which exhibit anticancer activity by using gold nanoparticles as templates (figure 4).…”

Section: N6l-functionalized Nanocapsulesmentioning

confidence: 99%

Cell surface nucleolin as active bait for nanomedicine in cancer therapy: a promising option

Ferrara¹,

Belbekhouche²,

Habert³

et al. 2021

Nanotechnology

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HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.

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Section: N6l-functionalized Nanocapsulesmentioning

confidence: 99%

Cell surface nucleolin as active bait for nanomedicine in cancer therapy: a promising option

Ferrara¹,

Belbekhouche²,

Habert³

et al. 2021

Nanotechnology

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“…[171] Multilayer capsules with glucose responsiveness for insulin release were also prepared by Belbekhouche and co-workers. [172] The authors prepared modified alginate by amide formation using 3-aminophenylboronic acid, (24) and deposited this material in alternating layers with polyvinylpyrrolidone using CaCO 3 microparticles as a sacrificial templates, later removed by action of EDTA upon completion of the LbL assembly process. Insulin loading was performed utilizing the porous nature of CaCO 3 before deposition of the first layer.…”

Section: Capsulesmentioning

confidence: 99%

Insulin Delivery Using Dynamic Covalent Boronic Acid/Ester‐Controlled Release

Banach

Williams

Fossey

2021

Advanced Therapeutics

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The number of people affected by diabetes mellitus increases globally year on year. Elevated blood glucose levels may result from a lack of insulin to manage these levels and can, over a prolonged period, lead to serious repercussions. Diabetes mellitus patients must monitor and control their blood‐glucose levels with invasive testing and often alongside administration of intravenous doses of insulin, which can often lead to suboptimal compliance. To mitigate these issues, “closed‐loop” insulin delivery systems are deemed to be among superior options for rapid relief from the demanding and troublesome necessity of self‐directed care. The reversible dynamic covalent chemistry of boronic acid derivatives and their competitive affinity to 1,2‐ and 1,3‐diols (such as those present in saccharides) allows for the design and preparation of responsive self‐regulated insulin delivery materials which respond to elevated and changing glucose levels. A range of meritorious and noteworthy contributions in the domain of boron‐mediated insulin delivery materials is surveyed, and providing a multidisciplinary context in the realisation of the ambitious goal of ultimately addressing the desire to furnish glucose‐responsive insulin delivery materials through innovative synthesis and rigorous testing is targetted.

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“…Interestingly, the concentration-dependent glucose responsiveness was reached via the incorporation of phenylboronic acid moieties inside the alginate chain. 71 Pettignano et al reported the facile preparation of a multistimuli-responsive, self-healing, injectable and biocompatible soft biohydrogel exclusively from a boronic acid-modified alginate without the need for any external diol source and/or divalent cations (usually Ca 2+ ). 32 In addition to displaying good biocompatibility upon encapsulation of cells, which were able to survive gel injection and self-healing processes, the system exhibited extraordinary elasticity.…”

Section: Alginate-containing Hydrogelsmentioning

confidence: 99%

“…For instance, glucose-responsive multilayer capsules were prepared by layer-by-layer deposition of an alginate derivative and polyvinylpyrrolidone (PVPON). Interestingly, the concentration-dependent glucose responsiveness was reached via the incorporation of phenylboronic acid moieties inside the alginate chain …”

Section: General Overview: Polysaccharide-based Hydrogelsmentioning

confidence: 99%

Advanced Functional Hydrogel Biomaterials Based on Dynamic B–O Bonds and Polysaccharide Building Blocks

et al. 2020

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Dynamic covalent chemistry applied to polymers has attracted significant attention over the past decade. Within this area, this review highlights the recent research on polysaccharide-based hydrogels cross-linked by boronic-acid moieties, illustrating its versatility and relevance in biomaterials science to design self-healing, multiple stimuli-responsive, and adaptive biointerfaces and advanced functional devices. strategies and synthetic routes, compatibility with biological tissues, mechanical strength, high permeability to various solutes and high ionic conductivity) but, in addition, exhibit superior performance and cutting-edge properties. In particular, properties such as self-healing, 7 multiple stimuli-responsiveness, 8 and adaptive macroscale properties (shape-memory, stretchability, and reprocessability), [9][10][11] enable their use for real-world applications. 12 As the structure of physically cross-linked hydrogels is unstable under small environmental changes and present limited robustness, while the irreversible nature of chemical cross-links prevents their use in shear-thinning and self-healing applications, hydrogels based on dynamic covalent interactions have emerged as an attractive alternative to reach such high-value features. 13 Indeed, in comparison with non-covalent bonds (i.e. hydrogen bonds, 14,15 van der Waals interactions, 16 π-π stacking, 17 metal-ligand coordination, 18,19 electrostatic interactions, 20 or host-guest interactions 21 ), dynamic covalent chemistry exhibits higher stability and affords reversibility under specific conditions or stimuli. 22 The range of dynamic covalent chemistry that has been exploited to produce healable polymers includes nucleophilic substitutions, imine chemistry, Diels-Alder reactions, disulfide exchange chemistry, thiol-Michael exchange, transthioesterifications, boronic esters and boronates, Si-O exchange in siloxanes and silyl ethers, among others. 23 Briefly, the dynamic bond is a class of bond that can selectively, reversibly break and reform, under equilibrium conditions, without irreversible side reactions. 24 Dynamic covalent networks are influenced by external factors (such as temperature, water content, concentration, or the presence of Lewis bases, among others) and their components easily assemble and disassemble according to physicochemical cues. Due to their nature, dynamic bonds permit stress relaxation, material flow and higher stability, thus combining the advantages of both physically and

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Glucose-sensitive capsules based on hydrogen-bonded (polyvinylpyrrolidone / phenylboronic –modified alginate) system

Cited by 19 publications

References 30 publications

Cell surface nucleolin as active bait for nanomedicine in cancer therapy: a promising option

Cell surface nucleolin as active bait for nanomedicine in cancer therapy: a promising option

Insulin Delivery Using Dynamic Covalent Boronic Acid/Ester‐Controlled Release

Advanced Functional Hydrogel Biomaterials Based on Dynamic B–O Bonds and Polysaccharide Building Blocks

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