2021
DOI: 10.1007/s13300-021-01008-y
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Glucose Variability is Independently Correlated with Serum Level of Pigment Epithelium-Derived Factor in Type 2 Diabetes

Abstract: Introduction Pigment epithelium-derived factor (PEDF) may play a role in cardiometabolic disorders. The aim of this study was to investigate which biochemical and clinical parameters are independently associated with serum PEDF levels in patients with type 2 diabetes mellitus (T2DM). Methods We performed a cross-sectional analysis of 124 patients with T2DM who underwent continuous glucose monitoring (CGM) and blood chemistry analysis, including the diacron-reactive oxyg… Show more

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Cited by 3 publications
(4 citation statements)
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“…Similar to MetS and its components, evidence has also shown sex-based differences in serum PEDF levels, which were significantly higher in men than in women; 11 , 15 , 17 , 19 , 20 however, no sex difference was found in other studies. 10 , 16 , 21 , 22 In the current research, our data indicated that men have higher PEDF levels than women, and this difference was no longer evident in subjects without MetS. The above findings suggested that the sex difference in PEDF could be related to the difference in the metabolic components of the study population.…”
Section: Discussionsupporting
confidence: 48%
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“…Similar to MetS and its components, evidence has also shown sex-based differences in serum PEDF levels, which were significantly higher in men than in women; 11 , 15 , 17 , 19 , 20 however, no sex difference was found in other studies. 10 , 16 , 21 , 22 In the current research, our data indicated that men have higher PEDF levels than women, and this difference was no longer evident in subjects without MetS. The above findings suggested that the sex difference in PEDF could be related to the difference in the metabolic components of the study population.…”
Section: Discussionsupporting
confidence: 48%
“…Unlike HOMA-IR and TG, which have been shown to be unequivocally associated with PEDF, 10 , 11 , 37 a number of previous studies did not include ALT in their analysis and failed to find a correlation between PEDF and liver transaminases. 10 , 15 , 17 , 22 Serum aminotransferase has been regarded as a marker of nonalcoholic fatty liver disease (NAFLD) for a long time, and the accuracy of ALT in identifying NAFLD is higher than that of AST. 38 The liver is the main source of PEDF in the circulation, 39 and clinical studies have shown that serum PEDF levels are significantly elevated in patients with biopsy-proven NAFLD, and the relationship between the two is independent of other metabolic factors.…”
Section: Discussionmentioning
confidence: 99%
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“…[ 3 ] In recent years, PEDF has attracted much attention due to its metabolic regulation, and growing evidence suggests that circulating PEDF levels may be a biomarker for the severity and prognosis of various metabolic diseases, including metabolic syndrome (MetS), coronary heart disease and diabetes, as well as the complications of those diseases. [ 4 6 ] Previous studies have found sex differences in circulating PEDF levels, with PEDF levels in males being significantly higher than those in females. [ 5 , 7 , 8 ] In a 10-year longitudinal study, baseline PEDF levels were significantly higher in men than in women, and baseline PEDF levels predicted the development of MetS 10 years later in men but not in women.…”
Section: Introductionmentioning
confidence: 99%