"Glue sniffer's" heart?

Wiseman, Martin N.; Banim, S. O.

doi:10.1136/bmj.294.6574.739

Cited by 55 publications

(25 citation statements)

References 5 publications

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“…It contains the colorless gas called difluoroethane, an organofluorine compound which is used to create the cleaning blast when the trigger is pulled. Chronic cardiac toxicity from solvent abuse has been reported to result in irreversible myocardial damage [1,2]. Myocardial degenerative changes like interfibrillary edema, swollen and ruptured fibrils, congestive heart failure from chronic myocarditis and fibrosis have been reported in chronic inhalant abusers [1][2][3].…”

Section: Discussionmentioning

confidence: 99%

Huffing-Induced Cardiomyopathy: A Case Report

Samson¹,

Kado²,

Chapman³

2011

Cardiovasc Toxicol

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The intentional inhalation of fumes from gasoline or solvents for recreational purposes is commonly known as Huffing, Sniffing or Dusting (Anderson and Loomis in Am Fam Physician 68(5):869-874, 2003). Inhalant abuse is known to be "Cardio-toxic", causing sudden death and chronic myocardial damage (Meadows and Verghese in South Med J 89(5):455-462, 1996; Anderson and Loomis in Am Fam Physician 68(5):869-874, 2003). We report a 20-year-old white man who presented with altered mental status following ingestion of multiple alprazolam and oxycodone tablets. He was found to have diffused ST-T changes on his EKG. Cardiac enzymes were found to be elevated-CK: 599 U/L, CK-MB: 16.8 ng/mL and Troponin: 0.78 ng/mL. A transthoracic echocardiogram (TTE) revealed global left ventricular (LV) dysfunction with an ejection fraction (EF) of 10-15%. During hospitalization, the cardiac enzymes started trending downward and this was followed by spontaneous resolution of the LV dysfunction. The patient also admitted to inhaling "Dust-Off" spray 2-3 days prior to admission. Inhalant abuse can cause cardiomyopathy and should be considered a probable cause in patients presenting with cardiac dysfunction of unknown etiology, particularly in teenagers and young adults.

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Section: Discussionmentioning

confidence: 99%

Huffing-Induced Cardiomyopathy: A Case Report

Samson¹,

Kado²,

Chapman³

2011

Cardiovasc Toxicol

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“…29,38 Other causes of morbidity and mortality are related to the specific volatile chemical(s) used, associated health risk behaviors, drug-drug interactions, or additional material(s) found in the various inhaled products. Toxic effects attributed to specific chemicals include an ichthyosis-like dermatitis on the extremities, 25 decreased visual acuity, 41,42 sensorineural hearing loss, 42 cardiomyopathy, 43 toxic hepatitis, 44 distal renal tubular acidosis, 45 metabolic acidosis, 46 leukemia, 47 and aplastic anemia. 48 There is evidence that tolerance, dependence, and withdrawal symptoms can occur, and reported morbidities also include toluene embryopathy and neonatal withdrawal.…”

Section: Mechanism Of Abuse and Immediate Effects Of Inhalantsmentioning

confidence: 99%

Inhalant Abuse

Williams¹,

Storck²

2007

Pediatrics

122

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Inhalant abuse is the intentional inhalation of a volatile substance for the purpose of achieving an altered mental state. As an important, yet-underrecognized form of substance abuse, inhalant abuse crosses all demographic, ethnic, and socioeconomic boundaries, causing significant morbidity and mortality in school-aged and older children. This clinical report reviews key aspects of inhalant abuse, emphasizes the need for greater awareness, and offers advice regarding the pediatrician's role in the prevention and management of this substance abuse problem.

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“…Samples of cardiac muscle taken from inhalant abusers have shown interstitial edema, intramyocardial hemorrhages, contraction band necrosis, [70] edema, swollen and ruptured myofibrils, [71] and myocarditis and interstitial fibrosis [72].…”

Section: Inhalent Abusementioning

confidence: 99%

Drug Abuse-Induced Cardiac Arrhythmias: Mechanisms and Management

Ouali¹,

Guermazi²,

Guermazi³

et al. 2018

Cardiac Arrhythmias

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Toxicomania is a worldwide emerging problem threatening young population. Several reports highlighted its hazardous cardiovascular effects. Sudden cardiac death secondary to cardiac arrhythmias is the most occupying issue. Different forms of cardiac rhythm disorders may be induced by illicit drug abuse according to the type of drug and the mechanism involved. In this review, we exposed the main ventricular and supraventricular arrhythmia complicating the common recreational drugs, and we explained their different mechanisms as well as the particularities of management.

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"Glue sniffer's" heart?

Abstract: What is a name? The accuracy of using surnames and forenames in ascribing south Asian ethnic identity in English populations.J7 Epidemiol Community Health (in press).

Cited by 55 publications

References 5 publications

Huffing-Induced Cardiomyopathy: A Case Report

Huffing-Induced Cardiomyopathy: A Case Report

Inhalant Abuse

Drug Abuse-Induced Cardiac Arrhythmias: Mechanisms and Management

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