GLUT1 expression in pediatric adrenocortical tumors: a promising candidate to predict clinical behavior

Pinheiro, Céline; Granja, Sara; Longatto‐Filho, Adhemar; Faria, André M.; Fragoso, Maria Candida Barisson Villares; Lovisolo, Silvana Maria; Bonatelli, Murilo; Costa, Ricardo Filipe Alves; Lerário, Antônio Marcondes; Almeida, Madson Q.; Baltazar, Fátima; Zerbini, Maria Cláudia Nogueira

doi:10.18632/oncotarget.19135

Cited by 8 publications

(5 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[25] Furthermore, Pinheiro's work revealed that GLUT1 overexpression was a promising candidate to predict clinical behavior in pediatric adrenocortical tumors. [26] This study suggests the potential role of GLUT1 in a metabolic remodeling towards a hyperglycolytic phenotype in this malignancy. [26] Therefore, the alteration of tumor metabolism after GLUT1 was up-regulated needs to be further investigated.…”

Section: Discussionmentioning

confidence: 86%

See 1 more Smart Citation

Clinicopathological and prognostic significance of GLUT1 in breast cancer

Deng

Zou

Deng³

et al. 2018

Medicine

View full text Add to dashboard Cite

Background:Previous studies examining the prognostic value of glucose transporter 1 in breast cancer have yielded inconsistent results. We, therefore, performed a meta-analysis to clarify this issue.Methods:The research was reported according to the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. Relevant studies were retrieved from PubMed, Web of Science, EMBASE, and Cochrane library.Results:A total of 7 reports with 1861 patients were finally chosen. GLUT1 overexpression was found to be associated with high histological grade (OR = 3.74, 95% CI = 2.45–5.69, P < .001), negative PR status (OR = 0.33, 95% CI = 0.22–0.49, P < .001), and negative estrogen receptor (ER) status (OR = 0.27, 95% CI = 0.17–0.42, P < .001). However, no significant correlation was seen between GLUT1 levels and presence of lymph node metastasis, tumor size or the status of human epidermal growth factor receptor 2 (HER2). Overexpression of GLUT1 also correlated with a poor overall survival (hazard ratio [HR] = 1.65, 95% confidence interval [CI] = 1.17–2.31, P = .004) and disease-free survival (HR = 2.35, 95% CI = 1.4–3.94, P < .001). No evidence of significant publication bias was found.Conclusion:This meta-analysis indicates that GLUT1 expression is associated with poor prognostic and a series of clinicopathological features in breast cancer. GLUT1 might be a potential biomarker and therapeutic target in breast cancer.

show abstract

Section: Discussionmentioning

confidence: 86%

“…[26] This study suggests the potential role of GLUT1 in a metabolic remodeling towards a hyperglycolytic phenotype in this malignancy. [26] Therefore, the alteration of tumor metabolism after GLUT1 was up-regulated needs to be further investigated.…”

Section: Discussionmentioning

confidence: 89%

Clinicopathological and prognostic significance of GLUT1 in breast cancer

Deng

Zou

Deng³

et al. 2018

Medicine

View full text Add to dashboard Cite

show abstract

“…The final scores for ZNRF3 and β-catenin expressions levels were taken as the sum of both parameters (extent and intensity) and grouped into low expression levels (scores of 0–2) and high expression levels (scores of 3–7) as previously reported [ 99 , 102 ]. β-catenin expression in the different cellular localizations (membranous versus cytoplasmic and/or nuclear) was evaluated separately [ 102 , 103 , 104 ] ( Table 2 ).…”

Section: Methodsmentioning

confidence: 99%

Low Protein Expression of both ATRX and ZNRF3 as Novel Negative Prognostic Markers of Adult Adrenocortical Carcinoma

Brondani

Lacombe

Mariani

et al. 2021

IJMS

Self Cite

View full text Add to dashboard Cite

Adrenocortical carcinoma (ACC) is a rare malignancy that is associated with a dismal prognosis. Pan-genomic studies have demonstrated the involvement of ATRX and ZNRF3 genes in adrenocortical tumorigenesis. Our aims were to evaluate the protein expression of ATRX and ZNRF3 in a cohort of 82 adults with ACC and to establish their prognostic value. Two pathologists analyzed immuno-stained slides of a tissue microarray. The low protein expression of ATRX and ZNRF3 was associated with a decrease in overall survival (OS) (p = 0.045, p = 0.012, respectively). The Cox regression for ATRX protein expression of >1.5 showed a hazard ratio (HR) for OS of 0.521 (95% CI 0.273–0.997; p = 0.049) when compared with ≤1.5; for ZNRF3 expression >2, the HR for OS was 0.441 (95% CI, 0.229–0.852; p = 0.015) when compared with ≤2. High ATRX and ZNRF3 protein expressions were associated with optimistic recurrence-free survival (RFS) (p = 0.027 and p = 0.005, respectively). The Cox regression of RFS showed an HR of 0.332 (95%CI, 0.111–0.932) for ATRX expression >2.7 (p = 0.037), and an HR of 0.333 (95%CI, 0.140–0.790) for ZNRF3 expression >2 (p = 0.013). In conclusion, low protein expression of ATRX and ZNRF3 are negative prognostic markers of ACC; however, different cohorts should be evaluated to validate these findings.

show abstract

“…Also, intensity of staining was scored semi-qualitatively as follows: 0: negative; 1: weak; 2: intermediate; and 3: strong. The final score was defined as the sum of both parameters (extension and intensity) and grouped as negative (score 0–2) and positive (score 3–6), as previously described (28, 29). Only protein expression in plasma membrane was considered for CD44, GLUT1, and CAIX analysis, while for HKII and LDHV only cytoplasmic expression was considered for further analysis.…”

Section: Methodsmentioning

confidence: 99%

The Warburg Effect Is Associated With Tumor Aggressiveness in Testicular Germ Cell Tumors

et al. 2019

Self Cite

View full text Add to dashboard Cite

Testicular Germ Cell Tumors (TGCTs) are a rare group of neoplasms and the most common solid malignancy arising in young male adults. Despite the good response of these tumors to platinum-based chemotherapy, some patients are refractory to treatment and present poor clinical outcomes. During carcinogenesis and tumor development, cancer cells reprogram energy metabolism toward a hyper-glycolytic phenotype, an emerging hallmark of cancer. This phenomenon, known as the Warburg effect or aerobic glycolysis, involves overexpression of metabolism-related proteins, like glucose and monocarboxylate transporters, pH regulators and intracellular glycolytic enzymes. The metabolic profile of TGCTs is very little explored and, recently, this metabolic rewiring of cancer cells has been associated with aggressive clinicopathological characteristics of these tumors. The overexpression of monocarboxylate transporter 4 (MCT4) in TGCTs has been pointed out as a poor prognostic factor, as well as a promising therapeutic target. As a result, the main aim of the present study was to evaluate the prognostic value of key metabolism-related proteins in TGCTs. The immunohistochemical expressions of CD44 (as a monocarboxylate transporter chaperone), glucose transporter 1 (GLUT1), carbonic anhydrase IX (CAIX), hexokinase II (HKII) and lactate dehydrogenase V (LDHV) were evaluated in a series of 148 adult male patients with TGCTs and associated with clinicopathological parameters. In addition, paired normal tissues were also evaluated. The sample included 75 seminoma and 73 non-seminoma tumors. GLUT1 and CD44 expression was significantly increased in malignant samples when compared to paired normal samples. Conversely, HKII and LDHV expressions were significantly decreased in malignant samples. Concerning the clinicopathological values, CAIX expression was significantly associated with disease recurrence, while HKII expression was significantly associated with aggressive characteristics of TGCTs, including higher staging and non-seminoma histology. In conclusion, this study brings new insights on the metabolic characteristics of TGCTs, showing alterations in the expression of proteins related with the Warburg effect, as well as associations of the hyper-glycolytic and acid-resistant phenotype with aggressive clinicopathological parameters.

show abstract

GLUT1 expression in pediatric adrenocortical tumors: a promising candidate to predict clinical behavior

Cited by 8 publications

References 64 publications

Clinicopathological and prognostic significance of GLUT1 in breast cancer

Clinicopathological and prognostic significance of GLUT1 in breast cancer

Low Protein Expression of both ATRX and ZNRF3 as Novel Negative Prognostic Markers of Adult Adrenocortical Carcinoma

The Warburg Effect Is Associated With Tumor Aggressiveness in Testicular Germ Cell Tumors

Contact Info

Product

Resources

About