Glutamate agonists activate the hypothalamic–pituitary–adrenal axis through hypothalamic paraventricular nucleus but not through vasopressinerg neurons

Zelena, Dóra; Mergl, Zsuzsa; Makara, Gábor B.

doi:10.1016/j.brainres.2004.10.034

Cited by 51 publications

(35 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…catheter implanted into the right jugular vein under anesthesia (i.p. injection of ketamine (50 mg/kg, SelBruHa Allatgyogyaszati Kft, Budapest, Hungary)-xylazine (20 mg/kg, Spofa, Praha, Czech Republic)-promethazinium chloratum (0.2 ml/kg, EGIS, Budapest, Hungary) in physiological saline) (Zelena et al 2005). After surgery, the rats were allowed to recover for 2 days.…”

Section: Blood Samplingmentioning

confidence: 99%

Blunted HPA axis response in lactating, vasopressin-deficient Brattleboro rats

Fodor¹,

Pintér²,

Domokos³

et al. 2013

Journal of Endocrinology

Self Cite

View full text Add to dashboard Cite

Adaptation to stress is a basic phenomenon in mammalian life that is mandatorily associated with the activity of the hypothalamic-pituitary-adrenal (HPA) axis. An increased resting activity of the HPA axis can be measured during pregnancy and lactation, suggesting that these reproductive states lead to chronic load in females. In this study, we examined the consequences of the congenital lack of vasopressin on the activity of the HPA axis during lactation using vasopressindeficient Brattleboro rats. Virgin and lactating, homozygous vasopressin-deficient rats were compared with control, heterozygous rats. In control dams compared with virgins, physiological changes similar to those observed in a chronic stress state (thymus involution, adrenal gland hyperplasia, elevation of proopiomelanocortin mRNA levels in the adenohypophysis, and resting plasma corticosterone levels) were observed. In vasopressin-deficient dams, adrenal gland hyperplasia and resting corticosterone level elevations were not observed. Corticotropinreleasing hormone (Crh) mRNA levels in the hypothalamic paraventricular nucleus were elevated in only the control dams, while oxytocin (OT) mRNA levels were higher in vasopressin-deficient virgins and lactation induced a further increase in both the genotypes. Suckling-induced ACTH and corticosterone level elevations were blunted in vasopressin-deficient dams. Anaphylactoid reaction (i.v. egg white) and insulin-induced hypoglycemia stimulated the HPA axis, which were blunted in lactating rats compared with the virgins and in vasopressin-deficient rats compared with the controls without interaction of the two factors. Vasopressin seems to contribute to the physiological changes observed during lactation mimicking a chronic stress state, but its role in acute HPA axis regulation during lactation seems to be similar to that observed in virgins. If vasopressin is congenitally absent, OT, but not the CRH, compensates for the missing vasopressin; however, the functional restitution remains incomplete.

show abstract

Section: Blood Samplingmentioning

confidence: 99%

Blunted HPA axis response in lactating, vasopressin-deficient Brattleboro rats

Fodor¹,

Pintér²,

Domokos³

et al. 2013

Journal of Endocrinology

Self Cite

View full text Add to dashboard Cite

show abstract

“…It has been demonstrated that excitatory amino acids play an important role in the activation of the HPA axis [3], a key component of the stress responses. Glutamate is a well-known excitatory neurotransmitter, and known to be responsible for the fast excitatory input to magnocellular and parvocellular neurons in the PVN, where CRF is released [3].…”

Section: Adrenal Responsementioning

confidence: 99%

“…Glutamate is a well-known excitatory neurotransmitter, and known to be responsible for the fast excitatory input to magnocellular and parvocellular neurons in the PVN, where CRF is released [3]. In rats, glutamate injection into the third ventricle elevated plasma ACTH levels [38], and its agonists had similar effects as endogenous glutamate [39,40].…”

Section: Adrenal Responsementioning

confidence: 99%

“…Although the precise role of these neurotransmitters in stress response is unclear, there is increasing preclinical evidence that glutamate, which is an excitatory amino acid, plays an important role in the regulation of the HPA axis [2]. Glutamate is the most abundant excitatory amino acid neurotransmitter in the brain and has been known to activate the HPA axis and induce ACTH elevation [3].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Chronic Administration of Monosodium Glutamate under Chronic Variable Stress Impaired Hypothalamic-Pituitary-Adrenal Axis Function in Rats

Seo

Ham

Jin

et al. 2010

Korean J Physiol Pharmacol

View full text Add to dashboard Cite

The hypothalamic-pituitary-adrenal (HPA) axis is the primary endocrine system to respond to stress. The HPA axis may be affected by increased level of corticotrophin-releasing factors under chronic stress and by chronic administration of monosodium glutamate (MSG). The purpose of this study was to investigate whether chronic MSG administration aggravates chronic variable stress (CVS)-induced behavioral and hormonal changes. Twenty-four adult male Sprague-Dawley rats, weighing 200∼ 220 g, were divided into 4 groups as follows: water administration (CON), MSG (3 g/kg) administration (MSG), CVS, and CVS with MSG (3 g/kg) administration (CVS＋ MSG). In addition, for the purpose of comparing the effect on plasma corticosterone levels between chronic stress and daily care or acute stress, 2 groups were added at the end of the experiment; the 2 new groups were as follows: naïve mice (n=7) and mice exposed to restraint stress for 2 h just before decapitation (A-Str, n=7). In an open field test performed after the experiment, the CVS＋ MSG group significant decrease in activity. The increase in relative adrenal weights in the CVS and CVS＋ MSG group was significantly greater than those in the CON and/or MSG groups. In spite of the increase in the relative adrenal weight, there was a significant decrease in the plasma corticosterone levels in the CVS＋ MSG group as compared to all other groups, except the naïve group. These results suggest that impaired HPA axis function as well as the decrease in the behavioral activity in adult rats can be induced by chronic MSG administration under CVS rather than CVS alone.

show abstract

“…injection of ketamine (50 mg/kg, SelBruHa Allatgyogyaszati Kft, Budapest, Hungary) -xylazine (20 mg/kg, Spofa, Prague, Czech Republic) -promethazinium chloratum (0 . 2 ml/kg, EGIS, Budapset, Hungary) in physiological saline (Zelena et al 2005). After surgery, the animals were housed singly and allowed to recover for 2 days.…”

Section: Blood Samplingmentioning

confidence: 99%

The stimuli-specific role of vasopressin in the hypothalamus–pituitary–adrenal axis response to stress

Zelena

Domokos

Jain

et al. 2009

Journal of Endocrinology

Self Cite

View full text Add to dashboard Cite

Adaptation to a constantly changing environment is fundamental to every living organism. The hypothalamicpituitary-adrenocortical (HPA) axis is a key component of the adaptation process. The present study tests the hypothesis that vasopressin (AVP) is required for the HPA response to acute stimuli. To accomplish this, naturally AVP-deficient Brattleboro rats were exposed to a wide range of stimuli and their HPA response was compared with heterozygous littermattes. The circadian rhythmicity of plasma ACTH and corticosterone was not different between the two genotypes. The ACTH and corticosterone response to volume load, restraint or aggressive attack were decreased in AVP-deficient rats. The stress-induced increase in ACTH, but not corticosterone, was significantly impaired in AVPdeficient animals after novelty, elevated plus-maze, forced swim, hypoglycaemia, ulcerogenic cold immobilisation, lipopolysaccharide, hypertonic saline and egg white injection. The HPA response to social avoidance, ether inhalation and footshock was not different between the genotypes. In vitro, the hypophysis of AVP-deficient animals showed a reduction in stimulated ACTH production and their adrenal glands were hyporeactive to ACTH. A dissociation between the ACTH and corticosterone response was observed in several experiments and could not be explained by an earlier ACTH peak or enhanced adrenal sensitivity, suggesting the existence of paraadenohypophyseal neuroendocrine regulators. Loss of AVP affected the HPA response to a wide variety of stressors. Interestingly, the contribution of AVP to the HPA response was not specific for, nor limited to, a known stressor category. Thus, there is a context-specific requirement for AVP in stress-induced activation of the HPA axis.

show abstract

Glutamate agonists activate the hypothalamic–pituitary–adrenal axis through hypothalamic paraventricular nucleus but not through vasopressinerg neurons

Cited by 51 publications

References 55 publications

Blunted HPA axis response in lactating, vasopressin-deficient Brattleboro rats

Blunted HPA axis response in lactating, vasopressin-deficient Brattleboro rats

Chronic Administration of Monosodium Glutamate under Chronic Variable Stress Impaired Hypothalamic-Pituitary-Adrenal Axis Function in Rats

The stimuli-specific role of vasopressin in the hypothalamus–pituitary–adrenal axis response to stress

Contact Info

Product

Resources

About