Glutamine deprivation impairs function of infiltrating CD8<sup>+ </sup>T cells in hepatocellular carcinoma by inducing mitochondrial damage and apoptosis

Wang, Wei; Guo, Meng-Nan; Li, Ning; Pang, De-Quan; Wu, Jinghua

doi:10.4251/wjgo.v14.i6.1124

Cited by 11 publications

(6 citation statements)

References 33 publications

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“…Finally, hyaluronic acids are unbranched heteropolysaccharides that participate in the extracellular matrix and are secreted in the TME of cancer cells and were shown to play a role in stroma homeostasis maintenance, immune escape, stemness, migration, proliferation and invasion [49]. Hyaluronic acids also form a physical barrier that reduces immune cell infiltration in the TME [50]. Perturbations in hyaluronic metabolism cause a remodelling of the extracellular matrix that favours angiogenesis, CAF and macrophage recruitment [51].…”

Section: Discussionmentioning

confidence: 99%

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scFASTCORMICS: A Contextualization Algorithm to Reconstruct Metabolic Multi-Cell Population Models from Single-Cell RNAseq Data

Pacheco

Prohaska

et al. 2022

Metabolites

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Tumours are composed of various cancer cell populations with different mutation profiles, phenotypes and metabolism that cause them to react to drugs in diverse manners. Increasing the resolution of metabolic models based on single-cell expression data will provide deeper insight into such metabolic differences and improve the predictive power of the models. scFASTCORMICS is a network contextualization algorithm that builds multi-cell population genome-scale models from single-cell RNAseq data. The models contain a subnetwork for each cell population in a tumour, allowing to capture metabolic variations between these clusters. The subnetworks are connected by a union compartment that permits to simulate metabolite exchanges between cell populations in the microenvironment. scFASTCORMICS uses Pareto optimization to simultaneously maximise the compactness, completeness and specificity of the reconstructed metabolic models. scFASTCORMICS is implemented in MATLAB and requires the installation of the COBRA toolbox, rFASTCORMICS and the IBM CPLEX solver.

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Section: Discussionmentioning

confidence: 99%

“…In addition, glucose and lactate, T, B and CRC cells can uptake glutamine to fuel their metabolism. Glutamine is a source of carbon and nitrogen for anabolic pathways in tumours but also T cells that require glutamine for their effector functions, i.e., production of cytokines [50].…”

Section: Discussionmentioning

confidence: 99%

scFASTCORMICS: A Contextualization Algorithm to Reconstruct Metabolic Multi-Cell Population Models from Single-Cell RNAseq Data

Pacheco

Prohaska

et al. 2022

Metabolites

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“…In the glutamine-dominant HCC subgroup, CD8 + Teff cells shift to metabolizing exogenous lipids due to limited access of glutamine, reducing their quantity and cytolytic function [ 128 ]. In vitro co-culture assays have indicated that glutamine deprivation in the TME induces mitochondrial damage and CD8 T-cell apoptosis, impairing their tumorolytic function [ 129 ]. Apart from glutamine, glucose is critical for the metabolic fitness of tumor-infiltrating cytotoxic CD8 + T cells [ 18 ].…”

Section: Metabolic Interactions Between Tumor Cells and The Tmementioning

confidence: 99%

Metabolic reprogramming in the tumor microenvironment of liver cancer

Lin,

Rao,

Zhang

et al. 2024

J Hematol Oncol

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The liver is essential for metabolic homeostasis. The onset of liver cancer is often accompanied by dysregulated liver function, leading to metabolic rearrangements. Overwhelming evidence has illustrated that dysregulated cellular metabolism can, in turn, promote anabolic growth and tumor propagation in a hostile microenvironment. In addition to supporting continuous tumor growth and survival, disrupted metabolic process also creates obstacles for the anticancer immune response and restrains durable clinical remission following immunotherapy. In this review, we elucidate the metabolic communication between liver cancer cells and their surrounding immune cells and discuss how metabolic reprogramming of liver cancer impacts the immune microenvironment and the efficacy of anticancer immunotherapy. We also describe the crucial role of the gut–liver axis in remodeling the metabolic crosstalk of immune surveillance and escape, highlighting novel therapeutic opportunities.

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“…Serine is essential for T lymphocyte proliferation, while creatine contributes to slowing down the proliferation of cancer cells, similar to tryptophan, which enhances the cytotoxicity of the immune system cells [ 28 ]. It has also been demonstrated that glutamine deficiency contributes to the impairment of CD8 lymphocyte function in hepatocellular carcinoma [ 29 ]. Researchers emphasize the need for rapid nutritional diagnostics and the implementation of nutritional therapy, including an optimal protein intake ranging from 1.2 to 1.5 g/kg per day among HCC-diagnosed patients due to the risk of malnutrition and sarcopenia development, adversely affecting the tolerance of surgical treatment [ 30 , 31 , 32 ].…”

Section: Malnutrition As a Condition Requiring Intervention In The Pr...mentioning

confidence: 99%

The Influence of Diet and Its Components on the Development and Prevention of Hepatocellular Carcinoma (HCC)

Janota,

Szymanek

2024

Cancers

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Hepatocellular carcinoma (HCC) is diagnosed annually in nearly a million people worldwide, with approximately half of them being diagnosed at an advanced stage of the disease. Non-infectious risk factors for the development of HCC include an unbalanced lifestyle, including poor dietary choices characterized by a low intake of antioxidants, such as vitamins E and C, selenium, and polyphenols, as well as an excessive consumption of energy and harmful substances. Repeated bad dietary choices that contribute to an unbalanced lifestyle lead to the accumulation of fatty substances in the liver and to it entering an inflammatory state, which, without intervention, results in cirrhosis, the main cause of HCC. This review of the English language literature aims to present the food components that, when included in the daily diet, reduce the risk of developing HCC, as well as identifying foods that may have a carcinogenic effect on liver cells.

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Glutamine deprivation impairs function of infiltrating CD8⁺T cells in hepatocellular carcinoma by inducing mitochondrial damage and apoptosis

Cited by 11 publications

References 33 publications

scFASTCORMICS: A Contextualization Algorithm to Reconstruct Metabolic Multi-Cell Population Models from Single-Cell RNAseq Data

scFASTCORMICS: A Contextualization Algorithm to Reconstruct Metabolic Multi-Cell Population Models from Single-Cell RNAseq Data

Metabolic reprogramming in the tumor microenvironment of liver cancer

The Influence of Diet and Its Components on the Development and Prevention of Hepatocellular Carcinoma (HCC)

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Glutamine deprivation impairs function of infiltrating CD8+ T cells in hepatocellular carcinoma by inducing mitochondrial damage and apoptosis

Cited by 11 publications

References 33 publications

scFASTCORMICS: A Contextualization Algorithm to Reconstruct Metabolic Multi-Cell Population Models from Single-Cell RNAseq Data

scFASTCORMICS: A Contextualization Algorithm to Reconstruct Metabolic Multi-Cell Population Models from Single-Cell RNAseq Data

Metabolic reprogramming in the tumor microenvironment of liver cancer

The Influence of Diet and Its Components on the Development and Prevention of Hepatocellular Carcinoma (HCC)

Contact Info

Product

Resources

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Glutamine deprivation impairs function of infiltrating CD8⁺T cells in hepatocellular carcinoma by inducing mitochondrial damage and apoptosis