Glutamine supplementation influences immune development in the newly weaned piglet

Johnson, I. R.; Ball, Ron O; Baracos, Vickie E.; Field, Catherine J.

doi:10.1016/j.dci.2006.03.003

Cited by 43 publications

(26 citation statements)

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“…Lymphocyte subsets from the spleen, MLN and Peyer's patches (200,000 cells/well) were identified by two and three-colour immunofluorescence using fluorescence-activated cell sorting as previously described [25]. The following mouse anti-rat monoclonal antibodies were used in combination/singly: CD3 (T cells), CD4 (T helper/inducer cells), CD8 (Tcytotoxic/suppressor cells), OX12 (B cells), CD45RA (naïve Tcells), CD28 (co-stimulatory molecule for Tcell activation), CD25 (IL-2 receptor), OX6 (MHC class II), CD11b (macrophages), CD86 (antigen presenting cells, activated B cells).…”

Section: Lymphocyte Phenotype Determinationmentioning

confidence: 99%

Effect of CVT-E002™ (COLD-fX®) versus a ginsenoside extract on systemic and gut-associated immune function

Biondo

Goruk

Ruth

et al. 2008

International Immunopharmacology

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Section: Lymphocyte Phenotype Determinationmentioning

confidence: 99%

Effect of CVT-E002™ (COLD-fX®) versus a ginsenoside extract on systemic and gut-associated immune function

Biondo

Goruk

Ruth

et al. 2008

International Immunopharmacology

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“…Apart from improving the intestinal epithelium structure and piglet performance found by Zou et al (2006), recent studies indicate that glutamine serves important regulatory functions in nutrient metabolism (Wu 2010) and is a regulator of gene expression . Though majority of research have shown the benefits of the supplement of glutamine in piglet diets, some authors found no such improvements (Domeneghini et al 2004;Johnson et al 2006).…”

Section: Introductionmentioning

confidence: 99%

Effect of dietary glutamine, glucose and/or sodium butyrate on piglet growth, intestinal environment, subsequent fattener performance, and meat quality

Hańczakowska

Niwińska

Grela³

et al. 2014

CZECH J ANIM SCI

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ABSTRACT:The effect of feed supplementing with glutamine, glucose and/or sodium butyrate was estimated on 156 piglets. The after-effect of supplements on fattener performance, carcass traits, and meat quality was examined. Piglets were allocated to 5 groups and fed standard feed mixture alone (control -C) or supplemented with 10 g of l-glutamine, or 10 g of glucose, or 3 g of sodium butyrate per kg of diet or all of these compounds (groups GT, GC, SB, and GT+GC+SB, respectively). Six piglets from each group were slaughtered at 63 days of age, their intestines were prepared and their parts measured. Digesta from ileum and caecum was taken for analysis. Its acidity and volatile fatty acids content were evaluated. Morphological structure of duodenal and ileal epithelium was estimated. After 84 days of age 20 animals from each group were fed the standard mixture. After 100 days of fattening 8 pigs from each group were slaughtered, pH of meat was measured, and samples of the longissimus muscle were taken for analysis. Body weight gains of piglets fed diets supplemented with SB or all supplements were higher than those of controls. All supplements given together increased total intestinal weight and length. Epithelial villi in jejunum were the highest in piglets receiving all supplements. Their height in the duodenum ranged from 296 to 347 µm and in the jejunum they were higher: 336 -424 μm. After 100 days of fattening body weight of all experimental animals was higher than that of control. There was no significant difference in carcass and meat quality. Sodium butyrate added to the diet improved piglet performance probably due to changes in intestine development and in intestinal epithelium structure. This positive effect was enhanced to some extent by the addition of glutamine or glucose.

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“…Estos cambios pueden estar mediados por algunas citoquinas inflamatorias, que amplifican la respuesta inmune celular e inhiben el crecimiento (26,27). Se ha demostrado que la administración intravenosa de LPS produce inhibición en la absorción intestinal de algunos nutrientes, específicamente aminoácidos, siendo esta acción mediada por la citoquina TNF-α, la cual ha sido involucrada en la disfunción mucosal intestinal inducida por el LPS (28).…”

Section: Discussionunclassified

Lesiones en órganos de cerdos posdestete, inducidas por el lipopolisacárido de E. coli

Gutiérrez

2013

Rev MVZ Córdoba

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RESUMENObjetivo. Evaluar el efecto de la ingestión de varios niveles de Lipopolisacárido (LPS) de E. coli sobre las manifestaciones clínicas y lesiones en órganos de cerdos recién destetados. Materiales y métodos. El trabajo de campo se realizó en el Centro San Pablo, perteneciente a la Universidad Nacional de Colombia. El estudio se realizó con 52 cerdos destetados (6.5±0.5 kg) a los 21 días de edad. Los animales fueron alimentados durante 10 días con una dieta basal compuesta de leche y algunos de sus derivados, adicionada con cuatro niveles de LPS (0, 0.3, 0.5 y 1.0 µg/ml de alimento). Los cerdos se sacrificaron escalonadamente los días 1, 5, 7 y 10 posdestete y se tomaron muestras de intestino delgado, estómago, hígado, páncreas, corazón, pulmón, riñón y bazo. El monitoreo clínico y paraclínico se realizó diariamente durante la investigación. Para determinar la ganancia de peso, los animales fueron pesados el día del destete y el día del sacrificio. Resultados. Hubo diferencia (p<0.01) en las variables peso de los órganos y ganancia de peso, donde los animales que consumieron el mayor nivel de LPS presentaron los menores valores, llegando a su mínimo nivel el día 10 posdestete. Las variables presentación de: lesiones macroscópicas, diarreas, y temperatura rectal, aumentaron con el nivel de inclusión de LPS en la dieta, llegando a su máximo nivel el día 10 posdestete (p<0.01). Conclusiones. El LPS de E. coli provoca la inhibición del crecimiento corporal y de los órganos en estudio y una alta incidencia de diarreas. ORIGINAL 3535 ABSTRACTObjective: To evaluate the effects of the intake of several levels of lipopolysaccharides (LPS) from E. coli on clinical manifestations and injuries in organs of newly weaned pigs. Materials and methods. The experiment was conducted at the San Pablo Production Center of the Universidad Nacional de Colombia. 52 weaned pigs at 21 days of age were used. The animals were fed a basal diet composed of milk and some of its derivatives, and an addition of four LPS levels (0, 0.3, 0.5 and 1.0 µg / mg of feed) during 10 days. The pigs were sequentially sacrificed on days 1, 5, 7, and 10 after weaning, and samples of the small intestine, stomach, liver, pancreas, heart, lungs, kidney and spleen were extracted. Clinical and laboratory monitoring was performed daily during the investigation. To determine weight gain, the animals were weighed on weaning day, and on slaughter day. Results: There were statistical differences (p<0.01) in organ weights and weight gain, where animals that consumed the highest levels of LPS showed the lowest values, reaching the lowest level on day 10 post-weaning. The variables: macroscopic lesions, diarrhea, and rectal temperature increased with the increase in LPS levels in the diet, reaching their peaks on day 10 post-weaning (p<0.01). Conclusions: E. coli LPS causes inhibition of the studied body and organ growth parameters, and a high incidence of post-weaning diarrhea.

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Glutamine supplementation influences immune development in the newly weaned piglet

Cited by 43 publications

References 41 publications

Effect of CVT-E002™ (COLD-fX®) versus a ginsenoside extract on systemic and gut-associated immune function

Effect of CVT-E002™ (COLD-fX®) versus a ginsenoside extract on systemic and gut-associated immune function

Effect of dietary glutamine, glucose and/or sodium butyrate on piglet growth, intestinal environment, subsequent fattener performance, and meat quality

Lesiones en órganos de cerdos posdestete, inducidas por el lipopolisacárido de E. coli

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