Glutaraldehyde: Current Status and Uses

Ad, Russell

doi:10.1086/646845

Cited by 60 publications

(39 citation statements)

References 71 publications

(4 reference statements)

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“…ARTICLE the results from S. oneidensis MR-1 that showed 495% decrease in current amplitude after removing the soluble mediators 30 , the current retained 498% of original level in G. sulfurreducens DL-1, indicating that contributions from the mediated electron transfer process is negligible. Furthermore, after adding 0.1% glutaraldehyde as a biocide 32 to the measurement chamber, current generation was completely quenched within 30 min, verifying that the measured short-circuit current was associated with cellular metabolism rather than unknown electrochemical processes.…”

Section: Experimental Design and Device Characterizationmentioning

confidence: 76%

Probing single- to multi-cell level charge transport in Geobacter sulfurreducens DL-1

Jiang

Petersen

et al. 2013

Nat Commun

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Microbial fuel cells, in which living microorganisms convert chemical energy into electricity, represent a potentially sustainable energy technology for the future. Here we report the single-bacterium level current measurements of Geobacter sulfurreducens DL-1 to elucidate the fundamental limits and factors determining maximum power output from a microbial fuel cell. Quantized stepwise current outputs of 92(±33) and 196(±20) fA are generated from microelectrode arrays confined in isolated wells. Simultaneous cell imaging/tracking and current recording reveals that the current steps are directly correlated with the contact of one or two cells with the electrodes. This work establishes the amount of current generated by an individual Geobacter cell in the absence of a biofilm and highlights the potential upper limit of microbial fuel cell performance for Geobacter in thin biofilms.

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Section: Experimental Design and Device Characterizationmentioning

confidence: 76%

Probing single- to multi-cell level charge transport in Geobacter sulfurreducens DL-1

Jiang

Petersen

et al. 2013

Nat Commun

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“…Glutaraldehyde (2 to 4%) is a disinfecting agent effective against bacteria, viruses, fungi, and spores that is relatively inexpensive, is noncorrosive to metal, and does not damage endoscopes and processing equipment (5,33). Two percent aqueous solutions of glutaraldehyde killed vegetative bacteria in Ͻ2 min, fungi and viruses in Ͻ10 min, and spores of Bacillus spp.…”

Section: Relevance Of Cleaning and Disinfectionmentioning

confidence: 99%

Transmission of Infection by Flexible Gastrointestinal Endoscopy and Bronchoscopy

et al. 2013

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SUMMARY Flexible endoscopy is a widely used diagnostic and therapeutic procedure. Contaminated endoscopes are the medical devices frequently associated with outbreaks of health care-associated infections. Accurate reprocessing of flexible endoscopes involves cleaning and high-level disinfection followed by rinsing and drying before storage. Most contemporary flexible endoscopes cannot be heat sterilized and are designed with multiple channels, which are difficult to clean and disinfect. The ability of bacteria to form biofilms on the inner channel surfaces can contribute to failure of the decontamination process. Implementation of microbiological surveillance of endoscope reprocessing is appropriate to detect early colonization and biofilm formation in the endoscope and to prevent contamination and infection in patients after endoscopic procedures. This review presents an overview of the infections and cross-contaminations related to flexible gastrointestinal endoscopy and bronchoscopy and illustrates the impact of biofilm on endoscope reprocessing and postendoscopic infection.

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“…To explore further the role of the lysine residues in the interaction of GTA with the VP1 capsid protein of enteroviruses, the sequence of the protein was determined in 15 echovirus prototype strains (serotypes 1,3,4,5,7,13,14,15,19,20,24,26,29,31, and 33). The amino acid sequences were aligned with each other and with that of coxsackievirus B3, used as a reference (data not shown).…”

Section: Resultsmentioning

confidence: 99%

“…Two-percent-GTA-based products have been used to disinfect flexible endoscopes for about 30 years worldwide (24). Although GTA-containing disinfectants are currently discouraged in endoscope disinfection in some countries because of prion resistance and toxicological problems, GTA is still widely used in heat-sensitive medical devices and on environmental surfaces (1,9).…”

mentioning

confidence: 99%

Virucidal Efficacy of Glutaraldehyde against Enteroviruses Is Related to the Location of Lysine Residues in Exposed Structures of the VP1 Capsid Protein

Chambon

Archimbaud

Bailly

et al. 2004

Appl Environ Microbiol

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Glutaraldehyde (GTA) is a potent virucidal disinfectant whose exact mode of action against enteroviruses is not understood. Earlier reports showed that GTA reacts preferentially with the VP1 capsid protein of echovirus 25 and poliovirus 1 and that GTA has affinity for exposed lysine residues on proteins. To investigate further the inactivation of enteroviruses by GTA, seven strains were selected on the basis of differences in their overall number and the positions of lysine residues in the amino acid sequences of the VP1 polypeptide. Inactivation kinetics experiments were performed with 0.10% GTA. The viruses grouped into three clusters and exhibited significantly different levels of sensitivity to GTA. The results were analyzed in the light of current knowledge of the three-dimensional structure of enteroviruses and the viral life cycle. The differences observed in sensitivity to GTA were related to the number of lysine residues and their locations in the VP1 protein. The overall findings suggest that the BC and DE loops, which cluster at the fivefold axis of symmetry and are the most exposed on the outer surface of the virions, are primary reactive sites for GTA.

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Glutaraldehyde: Current Status and Uses

Cited by 60 publications

References 71 publications

Probing single- to multi-cell level charge transport in Geobacter sulfurreducens DL-1

Probing single- to multi-cell level charge transport in Geobacter sulfurreducens DL-1

Transmission of Infection by Flexible Gastrointestinal Endoscopy and Bronchoscopy

Virucidal Efficacy of Glutaraldehyde against Enteroviruses Is Related to the Location of Lysine Residues in Exposed Structures of the VP1 Capsid Protein

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