Glutathione-functionalized magnetic thioether-COFs for the simultaneous capture of urinary exosomes and enrichment of exosomal glycosylated and phosphorylated peptides

Abstract

Exosomes play an irreplaceable role in physiological and pathological processes, and the study of proteomics (especially protein post-translational modifications, PTMs) in exosomes can reveal the pathogenesis of diseases and screen...

Metalated covalent organic frameworks: from synthetic strategies to diverse applications

“…In addition, metal nanoparticle loaded COFs also possess the ability to selectively enrich polypeptides. 318,437 As reported by Li et al in 2020, IBAs-AuNPs/COF composites with the insulin aptamer on the AuNPs/COF surface exhibit good specificity for insulin enrichment in the presence of high levels of human immunoglobulins, lysozyme, or biotin. 335 The selective enrichment of insulin from the serum of diabetic patients by IBAs-AuNPs/COF can then be used for insulin quantification through mass spectrometric analysis.…”

Magnetic Ti3C2 MXene Nanomaterials for Doxorubicin Adsorption from Aqueous Solutions: Kinetic, Isotherms, and Thermodynamic Studies

“…Recently, iron oxide nanoparticles (Fe 3 O 4 NPs) have attracted extensive attention in the field of environmental remediation. , However, unmodified Fe 3 O 4 NPs are difficult to recycle in practical application because they are easy to agglomerate and form clusters . Up to now, various magnetic adsorbents that were modified or coated different groups on the surface of Fe 3 O 4 NPs to provide functionality and stability have been prepared for inorganic, organic, and biological analysis. , For example, multilayer cucurbit[6]­uril-based magnetic nanoparticles were prepared based on host-guest interactions by Jia’s group, and the compound was successfully used as a blood purification material to remove lipoprotein from plasma …”

“…24 Up to now, various magnetic adsorbents that were modified or coated different groups on the surface of Fe 3 O 4 NPs to provide functionality and stability have been prepared for inorganic, organic, and biological analysis. 25,26 For example, multilayer cucurbit [6]uril-based magnetic nanoparticles were prepared based on host-guest interactions by Jia's group, and the compound was successfully used as a blood purification material to remove lipoprotein from plasma. 27 β-cyclodextrin (β-CD) is a kind of nontoxic cyclic oligosaccharides, and the most significant structure is hydrophilic exterior and hydrophobic interior cavity.…”

Preparation of tannic acid and l-cysteine functionalized magnetic composites for synergistic enrichment of N-glycopeptides followed by mass spectrometric analysis

“…(ii) The superparamagnetic property of Fe 3 O 4 accelerates the enrichment process and improves the enrichment efficiency to some extent. 44,45 (iii) The combination of TA and l -Cys can be facilely achieved based on the strong reducing effect of TA toward Ag + (ref. 46–48) and further introduction of l -Cys through the Ag–S bond.…”