Glutathione polymorphism in the sheep red blood cells

Agar, N.S.

doi:10.1016/0020-711x(75)90001-4

Cited by 14 publications

(4 citation statements)

References 28 publications

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“…Erythrocyte GSH concentrations in sheep are usually expressed in milligrams per deciliter RBC (1). There was a strong positive correlation between the values of erythrocyte GSH in milligrams per deciliter RBC and milligrams per gram Hb, perhaps because of the concurrent positive correlation between PCV and Hb.…”

Section: S Resultsmentioning

confidence: 99%

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Concentrations du glutathion érythrocytaire chez des moutons nigérians de la région du Sahel

Igbokwe¹,

Bah²

1999

Rev. Elev. Med. Vet. Pays Trop.

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Les concentrations du glutathion érythrocytaire de 101 moutons de plusieurs races du Sahel nigérian ont varié de 9,2 à 109,4 (45,1 ± 18,8) mg/dl de globules rouges ou de 0,3 à 3,1 (1,7 ± 0,6) mg/g d’hémoglobine. La majorité des moutons (72,3 p. 100) avaient de faibles concentrations érythrocytaires (< 55 mg/dl de globules rouges). La distribution des fréquences des valeurs a été normale avec des classes modales allant de 41 à 50 mg/dl de globules rouges et de 1,6 à 2,0 mg/g d’hémoglobine. Les valeurs du glutathion érythrocytaire étaient fortement corrélées en termes de milligrammes par décilitre de globules rouges et de milligrammes par gramme d’hémoglobine, mais ne l’étaient pas avec l’hématocrite, l’hémoglobine et l’anémie.

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Section: S Resultsmentioning

confidence: 99%

“…An inheritable erythrocyte glutathione (GSH) polymorphism was reported in several sheep breeds according to a review by Agar (1). Sheep having erythrocyte GSH concentrations above 55 mg/dl of red blood cells (RBC) were considered to have high (normal) GSH, while those with values below were considered to have low (deficient) GSH (19).…”

Section: S Introductionmentioning

confidence: 99%

Concentrations du glutathion érythrocytaire chez des moutons nigérians de la région du Sahel

Igbokwe¹,

Bah²

1999

Rev. Elev. Med. Vet. Pays Trop.

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“…10 However, it is not yet known why there is a high concentration of GSH in liver cells, why its turnover is so rapid or what factors regulate its concentration, it is known, however, that the genetic deficiency of GSH in the red blood cell, due to deficiency of one or other enzyme responsible for the synthesis of this tripeptide, results in haemolytic anaemia in man l7 but not in sheep. 18 It should be interesting to examine the effect of halothane anaesthesia in patients suffering from such a GSH deficiency.…”

Section: Resultsmentioning

confidence: 99%

Effect of Halothane and Enflurane Anaesthesia on the Level of Reduced Glutathione in Human Red Blood Cells

Agar

Lewis

1980

Anaesth Intensive Care

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No significan t changes were found in packed cell volume, haemoglobin concentration and red cell glutathione levels in patients before and after anaesthesia with halothane or enflurane. These results, though unable to explain the mechanism, support the earlier suggestion that glutathione plays little, if any, role in protecting liver against toxic effects of these anaesthetic agents or their metabolites.

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“…The significant difference observed in GSH concentration between breeds is of dubious importance since the concentration of erythrocyte GSH varies widely among sheep within a breed (Agar, 1975) and as so few animals were involved. The more important features of the results are the similarity in the responses of GSH concentration to methionine infusions by both breeds, the differences in these responses between seasons and the lower GSH concentration in summer than in winter.…”

Section: Discussionmentioning

confidence: 99%

Effect of a duodenal infusion of methionine on erythrocyte reduced glutathione of sheep

1979

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Reduced glutathione (GSH) is synthesized within blood erythrocytes from the constituent nonessential amino acids, glutamic acid, cysteine and glycine. The concentration of GSH in. erythrocytes can therefore be affected by the permeability of erythrocyte membranes to certain of these amino acids and their availability within the erythrocyte (Young, Ellory & Tucker, 1976; Smith, 1977). Alterations in the activity of the two enzymes responsible for GSH synthesis, γ-glutamyl cysteine synthetase and glutathione synthetase can likewise influence GSH concentration (Smith, Lee & Mia, 1973; Blume, Paniker & Beutler, 1974; Wellner et al. 1974; Board, Morris & Peter, 1976).

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Glutathione polymorphism in the sheep red blood cells

Cited by 14 publications

References 28 publications

Concentrations du glutathion érythrocytaire chez des moutons nigérians de la région du Sahel

Concentrations du glutathion érythrocytaire chez des moutons nigérians de la région du Sahel

Effect of Halothane and Enflurane Anaesthesia on the Level of Reduced Glutathione in Human Red Blood Cells

Effect of a duodenal infusion of methionine on erythrocyte reduced glutathione of sheep

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