Glutathione-responsive nanoplatforms trigger gaseous intervention of intestinal inflammation through TLR4/MD2/MyD88/NF-κB/iNOS pathway activation and gut microbiota modulation

Li, Yanfei; Zhu, Beiwei; Chen, Tao; Chen, Lihang; Wu, Di; Wang, Xinchuang; Li, Dongmei; Li, Wei; Sun, Yinshi; Hu, Jiangning

doi:10.1016/j.cej.2024.152849

Chemical Engineering Journal

2024

DOI: 10.1016/j.cej.2024.152849

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Glutathione-responsive nanoplatforms trigger gaseous intervention of intestinal inflammation through TLR4/MD2/MyD88/NF-κB/iNOS pathway activation and gut microbiota modulation

Yanfei Li,

Beiwei Zhu,

Tao Chen

et al.

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Cited by 5 publications

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Application of Polymers as Drug Nanocarriers in the Oral Treatment of Ulcerative Colitis

Liu,

Huang,

et al. 2024

ChemistrySelect

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Ulcerative colitis (UC) is a chronic non‐specific inflammatory disease of the intestines with a high prevalence. Polymer‐prepared nanoparticles are well‐targeted, highly biocompatible, and have high potential for personalized therapy. Polymer nanoparticles are able to achieve localized therapy through their unique design. First, this review compares the advantages and disadvantages of natural and synthetic polymeric materials as well as describes the application of polymeric nanoparticles in UC therapy. Then, the preparation, characterization methods, and current challenges of common polymer nanoparticles are presented. Next, one‐by‐one examples of polymer nanoparticle‐targeted drug delivery strategies for the treatment of UC are presented. In addition, polymer nanoparticle‐based therapeutic approaches for UC, including anti‐inflammatory therapies, reactive oxygen species scavenging therapies, and intestinal flora modulation therapies, are presented. Finally, future research directions for polymer nanoparticles in UC therapy are discussed and current challenges are identified. The aim of this paper is to provide valuable references and guidance for researchers to design and develop novel UC therapies.

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Application of Polymers as Drug Nanocarriers in the Oral Treatment of Ulcerative Colitis

Liu,

Huang,

et al. 2024

ChemistrySelect

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Metabolic reprogramming in sepsis-associated acute kidney injury: insights from lipopolysaccharide-induced oxidative stress and amino acid dysregulation

Turk,

Temiz,

Koyuncu

2024

Mol Biol Rep

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Lipoic acid-functionalized platycodin D nanocarrier improves mitochondrial dysfunction and reverses diabetes

Shen,

Wang,

Xing

et al. 2024

Chemical Engineering Journal

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Glutathione-responsive nanoplatforms trigger gaseous intervention of intestinal inflammation through TLR4/MD2/MyD88/NF-κB/iNOS pathway activation and gut microbiota modulation

Cited by 5 publications

References 84 publications

Application of Polymers as Drug Nanocarriers in the Oral Treatment of Ulcerative Colitis

Application of Polymers as Drug Nanocarriers in the Oral Treatment of Ulcerative Colitis

Metabolic reprogramming in sepsis-associated acute kidney injury: insights from lipopolysaccharide-induced oxidative stress and amino acid dysregulation

Lipoic acid-functionalized platycodin D nanocarrier improves mitochondrial dysfunction and reverses diabetes

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