Glutathione S-transferase Gene Polymorphisms and Susceptibility to Acute Myeloid Leukemia: Meta-analyses

Abstract

Objective: A large body of evidence has shown the possible relevance of polymorphisms of the genes that encode glutathione S-transferase m, p and u (GSTM1, GSTP1 and GST1, respectively) to the susceptibility of acute myeloid leukemia, but the exact association still remains uncertain. Therefore, we performed a meta-analysis to derive a more precise estimation of the relationship. Methods: A comprehensive literature search of PubMed and Web of Knowledge electronic databases was conducted to collect relevant studies until 20 February 2014. References of the retrieved articles were also screened. The extracted data were statistically analyzed, and pooled odds ratios with 95% confidence intervals were calculated to estimate the association strength using Review Manager version 5.2. Results: Twenty-nine studies were included in the meta-analysis. The pooled analyses revealed that the GSTM1-null genotype was associated with an increased risk of acute myeloid leukemia in East Asians (P ¼ 0.01; odds ratio ¼ 1.22; 95% confidence interval ¼ 1.05 -1.42), and GSTT1-null genotype in Caucasians (P , 0.0001; odds ratio ¼ 1.48; 95% confidence interval ¼ 1.29 -1.69). There was also a predilection towards the female gender for both of these polymorphisms. For GSTP1 Ile105Val polymorphism, no significant association was found under any contrast model. In addition, the presence of the double-null genotypes increased the risk of acute myeloid leukemia in both Caucasians and East Asians. Conclusions: This meta-analysis suggested that heritable GST status could influence the risk of developing acute myeloid leukemia.

From Six Gene Polymorphisms of the Antioxidant System, Only GPX Pro198Leu and GSTP1 Ile105Val Modulate the Risk of Acute Myeloid Leukemia

“…In contradiction, in a meta-analysis performed by Tang et al GSTP1 polymorphism was not associated with acute leukemia risk in Asians [ 18 ]. Similar results to those reported by Tang et al were observed by He et al [ 37 ].…”

“…In contradiction, a recent meta-analysis performed by He et al showed that GSTM1 null genotype was associated with the risk of developing AML in East Asians while GSTT1 null genotype was a risk factor for AML in Caucasians [ 37 ]. The same study revealed that the presence of both GSTM1 and GSTT1 null genotypes might increase significantly the risk of AML in both Asians and Caucasians [ 37 ].…”

Glutathione S-Transferase M1 and T1 Gene Polymorphisms in Patients with Chronic Plaque-Type Psoriasis: A Case-Control Study

“…Polymorphisms of GST isoenzymes were studied in various disease states, and null gene expression was implicated as a susceptibility factor for particular diseases [ 7 , 12 , 13 ]. However, GST isoenzyme polymorphisms were also studied in a number of dermatologic diseases to be able to account for increased disease susceptibility with regard to null enzyme expression [ 6 , 8 , 14 , 15 ].…”

Role of glutathione S-transferase M1, T1 and P1 gene polymorphisms in childhood acute lymphoblastic leukemia susceptibility in a Turkish population

“… Rollinson et al (2000) reported that there was an association between the null GSTT1 and the null GSTM1 genotypes and the risk of developing AML. In a meta-analysis, it was suggested that the presence of the dual null genotype GSTM1 - GSTT1 increased the risk of developing AML in both the Caucasians and the East Asians ( He et al, 2014 ). Lemos et al (1999) showed that there was no statistically significant relationship between the GSTM1 gene status and the development of CLL.…”