Glutathione S-transferase polymorphisms in thyroid cancer patients

Hernández, Alba; Céspedes, Walkiria; Xamena, N.; Surrallés, Jordi; Creus, A.; Galofré, Pere; Marcos, Ricard

doi:10.1016/s0304-3835(02)00580-3

Cited by 26 publications

(24 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…5 Our results from separate analyses of these genes are in accordance with the literature, although we observed the presence of GSTM1 in 72.2% (13/18) and GSTT1 in 88.9% (16/18) of the benign tumor cases. These frequencies are quite high and, although non-signifi cant, cannot be ignored.…”

Section: Discussionsupporting

confidence: 92%

Comparative analysis of the prevalence of the glutathione S-transferase (GST) system in malignant and benign thyroid tumor cells

et al. 2007

View full text Add to dashboard Cite

CONTEXT AND OBJECTIVE: When null, the mu and theta genes of the glutathione S-transferase system (GSTM1 and GSTT1, respectively) are related to malignant tumors affecting the lungs, colon, prostate, bladder and head and neck. In the thyroid, the appearance of cancer has been correlated with deletion of these genes. The aim of this study was to compare the frequencies of these genes in patients with benign and malignant tumors of the thyroid gland. DESIGN AND SETTINGS: This was a cross-sectional clinical trial carried out in the Head and Neck Surgery Division, Faculdade de Medicina da Santa Casa de São Paulo. METHODS: Samples of thyroid tissue were collected from 32 patients and divided into two groups: benign tumor (A) and malignant tumor (B). After DNA extraction, the genes were amplified using PCR. RESULTS: The B group presented four cases of positive genotyping for both genes, seven positive for GSTT1 and negative for GSTM1, two negative for GSTT1 and positive for GSTM1, and only one case of double negative. The A group showed 11 cases with positive genotyping for both genes and none with the double negative genotype. CONCLUSION: In this study, there was no relationship between the presence of the GSTT1 and GSTM1 genes and the benign and malignant thyroid tumors.

show abstract

Section: Discussionsupporting

confidence: 92%

Comparative analysis of the prevalence of the glutathione S-transferase (GST) system in malignant and benign thyroid tumor cells

et al. 2007

View full text Add to dashboard Cite

show abstract

“…In general, it is believed that susceptibility genetic factors are crucial in the genomics of cancer development; thus, association studies aiming to identify susceptibility genes for cancer are taking important relevance. This type of study has recently emerged for thyroid cancer (7)(8)(9)(10)(11)(12), although no specific genetic factor for thyroid cancer susceptibility has yet been described. In a previous study, we have reported that the chromosome 1p12-13is related to thyroid cancer susceptibility (13).…”

Section: Introductionmentioning

confidence: 99%

Strong Association of Chromosome 1p12 Loci with Thyroid Cancer Susceptibility

Baida

Akdi

González-Flores

et al. 2008

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

Several genes directly related to thyroid cancer development have been described; nevertheless, the genetic pathways of this tumorigenesis process are unknown. Together with environmental factors, susceptibility genes could have an important role in thyroid cancer. Our previous studies suggest that the chromosome 1p12-13 is related to thyroid cancer incidence. Here, we extend the analysis with a case-control association study in a Spanish population. Thus, six singlenucleotide polymorphisms were genotyped, covering 2.4 Mb of the 1p12-13 region. A statistically significant association between thyroid cancer incidence and the rs2145418 and rs4658973 polymorphisms was found (P < 0.0001). No association was detected for the other four polymorphisms studied. The rs2145418 marker showed a significant odds ratio of 5.0 [95% confidence interval (95% CI), 2.85-8.83] and 9.2 (95% CI, 4.50-21.6) for heterozygous and homozygous G-variant alleles, respectively. For rs4658973, the odds ratios were 0.40 (95% CI, 0.26-0.62) and 0.07 (95% CI, 0.03-0.18) for heterozygous and homozygous G-variant alleles, respectively. These markers map into the 1p12 region, and no linkage disequilibrium was found between them, indicating an independent relation of these polymorphisms with thyroid cancer susceptibility. Our data provide evidence of a strong association of the chromosome 1p12 with thyroid cancer risk, and it is the first study describing susceptibility loci for thyroid cancer in this region. (Cancer Epidemiol Biomarkers Prev 2008;17(6):1499 -504)

show abstract

“…Gaspar et al (2004) observed that polymorphisms of GSTM1, GSTT1, and GSTP1 are risk factors for DTC in the Portuguese population, increasing the risk of developing the disease. However, these results were neither observed in the Spanish population (Hernandez et al 2003) nor in the Polish population, probably, due to the low number of individuals included (Marciniak et al 2006). Similarly, Li et al (2012) studied three polymorphisms of GST (M1, T1, and P1) with DTC risk in 1819 cases and 3189 controls (14 abstracts), and concluded that these polymorphisms were not associated with DTC susceptibility.…”

Section: Metabolization and Detoxification Systemsmentioning

confidence: 94%

The influence of the environment on the development of thyroid tumors: a new appraisal

Marcello¹,

Malandrino²,

Almeida³

et al. 2014

Endocrine Related Cancer

View full text Add to dashboard Cite

Most epidemiological studies concerning differentiated thyroid cancers (DTC) indicate an increasing incidence over the last two decades. This increase might be partially explained by the better access to health services worldwide, but clinicopathological analyses do not fully support this hypothesis, indicating that there are carcinogenetic factors behind this noticeable increasing incidence. Although we have undoubtedly understood the biology and molecular pathways underlying thyroid carcinogenesis in a better way, we have made very little progresses in identifying a risk profile for DTC, and our knowledge of risk factors is very similar to what we knew 30-40 years ago. In addition to ionizing radiation exposure, the most documented and established risk factor for DTC, we also investigated the role of other factors, including eating habits, tobacco smoking, living in a volcanic area, xenobiotics, and viruses, which could be involved in thyroid carcinogenesis, thus, contributing to the increase in DTC incidence rates observed.

show abstract

Glutathione S-transferase polymorphisms in thyroid cancer patients

Cited by 26 publications

References 23 publications

Comparative analysis of the prevalence of the glutathione S-transferase (GST) system in malignant and benign thyroid tumor cells

Comparative analysis of the prevalence of the glutathione S-transferase (GST) system in malignant and benign thyroid tumor cells

Strong Association of Chromosome 1p12 Loci with Thyroid Cancer Susceptibility

The influence of the environment on the development of thyroid tumors: a new appraisal

Contact Info

Product

Resources

About