2019
DOI: 10.1002/ps.5425
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Glutathione transferase plays a major role in flufenacet resistance of ryegrass (Lolium spp.) field populations

Abstract: BACKGROUND: Herbicides inhibiting the synthesis of very long-chain fatty acids (HRAC group K 3 , WSSA group 15), such as flufenacet, play an important role in weed management strategies, particularly when herbicide resistance to inhibitors with other modes of action, such as acetolactate synthase or acetyl coenzyme A carboxylase (ACCase), has already evolved. So far, only a few cases of resistance towards inhibitors of the synthesis of very long-chain fatty acids have been described. In this study, we characte… Show more

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Cited by 46 publications
(57 citation statements)
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References 31 publications
(51 reference statements)
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“…With a DT 50 of 43 h, it degraded flufenacet significantly faster than the susceptible reference population Herbiseed‐S with a DT 50 of 121 h. Metabolites detected in extracts from seedlings of these populations suggest that flufenacet was detoxified via the same pathway in both populations. As described for Lolium spp., flufenacet was detoxified by conjugation to glutathione . Subsequent cleavage of glycyl known to be catalyzed by vacuolar carboxypeptidases likely resulted in the formation of a glutamyl–cysteine conjugate after vacuolar sequestration.…”
Section: Discussionmentioning
confidence: 99%
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“…With a DT 50 of 43 h, it degraded flufenacet significantly faster than the susceptible reference population Herbiseed‐S with a DT 50 of 121 h. Metabolites detected in extracts from seedlings of these populations suggest that flufenacet was detoxified via the same pathway in both populations. As described for Lolium spp., flufenacet was detoxified by conjugation to glutathione . Subsequent cleavage of glycyl known to be catalyzed by vacuolar carboxypeptidases likely resulted in the formation of a glutamyl–cysteine conjugate after vacuolar sequestration.…”
Section: Discussionmentioning
confidence: 99%
“…Comparisons of expression levels of GST‐encoding genes between flufenacet resistant A. myosuroides (Dücker et al , unpublished) and Lolium spp . will allow studying the pathways involved in flufenacet detoxification in detail.…”
Section: Discussionmentioning
confidence: 99%
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“…Glutathione S-transferase have been reported mainly function in response to biotic and abiotic stresses, such as oxidative stress (55), high/low temperature stress (56,57) and different pathogen invasion (58)(59)(60). As well, a high concentration of glutathione S-transferase resulted in decreased chlorophyll content (61). When albino mutant is exposed to light, a lethal factor rather than a gift, the mutant presented (Csa4G304240, Csa4G303170) ( Fig.…”
Section: Discussionmentioning
confidence: 98%
“…The study of NTSR is further complicated by the many combinations of weed species and registered herbicides for which multiple resistance mechanisms are possible [31]. The genetic basis and inheritance of herbicide resistance can be complex [33,34], such as NTSR mechanisms that are quantitative between populations and between individuals in a given population [35][36][37][38][39]. Elucidating the basis of NTSR to one herbicide in one species is not necessarily extensible to other herbicides and other species.…”
Section: Diversity Of Evolutionary Strategies In Weedsmentioning
confidence: 99%