Glycated hemoglobin biosensing integration formed on Au nanoparticle-dotted tubular TiO2 nanoarray

Jain, Utkarsh; Singh, Anamika; Kuchhal, N. K.; Chauhan, Nidhi

doi:10.1016/j.aca.2016.09.026

Cited by 22 publications

(12 citation statements)

References 37 publications

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“…These white blood cells (WBCs) are not fully formed and are known to be either blast cells or leukemia cells. Their symptoms are bruising and bleeding, extreme tiredness, higher risk of infections and fever, which are caused by the absence of healthy blood cells [55,56]. The disease can be diagnosed by bone marrow biopsies and blood tests.…”

Section: Introductionmentioning

confidence: 99%

RETRACTED: Ultra-Sensitive Biosensor with Simultaneous Detection (of Cancer and Diabetes) and Analysis of Deformation Effects on Dielectric Rods in Optical Microstructure

et al. 2021

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This study proposes a refractive index sensor for the simultaneous detection of cancer and diabetes based on photonic crystals (PhC). The proposed PhC composed of silicon rods in the air bed arranged in a hexagonal lattice forms the fundamental structure. Two tubes are used to place the cancerous or diabetic samples for measurement. The sensor’s transmission characteristics are simulated and analyzed by solving Maxwell’s electromagnetic equations using the finite-difference time-domain approach for samples being studied. Therefore, diabetes and cancer are detected according to the changes in the refractive index of the samples using the laser source centered at 1550 nm. Considering the findings, the sensor’s geometry changes to adjust the suggested sensitivity and quality factor of structure. According to the results, transmission power ranges between 91 and 100% based on the sample. Moreover, sensitivity ranges from 1294 to 3080 nm/RIU and the maximum Figure of Mertie is nearly FOM = 1550.11 ± 150.11 RIU−1 with the detection in range 31 × 10−6 RIU. In addition, the small area (61.56 μm2) of biosensor results in its appropriateness for different uses in compact photonic integrated circuits. Next, we changed the shape of the dielectric rods and investigated their effects on the sensitivity parameter. The sensitivity and figure of merit after changes in the shape of dielectric rods and nanocavities are at best S = 20,393 nm/RIU and FOM = 9104.017 ± 606.93 RIU−1, receptively. In addition, the resolution detection range is 203.93 × 10−6 RIU.

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Section: Introductionmentioning

confidence: 99%

RETRACTED: Ultra-Sensitive Biosensor with Simultaneous Detection (of Cancer and Diabetes) and Analysis of Deformation Effects on Dielectric Rods in Optical Microstructure

et al. 2021

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“…Utkars et al [92] formed a stable scaffold with AuNPs and point-like tubular TiO 2 ; 12-phosphotungstic acid was used as a reductant after depositing well-dispersed AuNPs on TiO 2 nanotubes, which accelerated electron transfer between proteins and conductors (Figure 5A). The response time was only three seconds, and the linear range for HbA1c detection was 0.5-2000 µM.…”

Section: Fao Typementioning

confidence: 99%

“…Figure 5. (A) An FAO/AuNP-PTA-TiO 2 nanocomposite was prepared on an ITO electrode (this figure was adapted from[92], with some modifications); (B) Preparation method of the FAO/PtNPs/RGO-NWCNT nanocomposite (this figure was adapted from[94], with some modifications); (C) CHIT-GO-AuNPs-FPOX nanocomposites were prepared on an FTO glass plate (this figure was adapted from[104], with some modifications).…”

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confidence: 99%

A Review of Electrochemical Sensors for the Detection of Glycated Hemoglobin

Zhan

Zhao

et al. 2022

Biosensors

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Glycated hemoglobin (HbA1c) is the gold standard for measuring glucose levels in the diagnosis of diabetes due to the excellent stability and reliability of this biomarker. HbA1c is a stable glycated protein formed by the reaction of glucose with hemoglobin (Hb) in red blood cells, which reflects average glucose levels over a period of two to three months without suffering from the disturbance of the outside environment. A number of simple, high-efficiency, and sensitive electrochemical sensors have been developed for the detection of HbA1c. This review aims to highlight current methods and trends in electrochemistry for HbA1c monitoring. The target analytes of electrochemical HbA1c sensors are usually HbA1c or fructosyl valine/fructosyl valine histidine (FV/FVH, the hydrolyzed product of HbA1c). When HbA1c is the target analyte, a sensor works to selectively bind to specific HbA1c regions and then determines the concentration of HbA1c through the quantitative transformation of weak electrical signals such as current, potential, and impedance. When FV/FVH is the target analyte, a sensor is used to indirectly determine HbA1c by detecting FV/FVH when it is hydrolyzed by fructosyl amino acid oxidase (FAO), fructosyl peptide oxidase (FPOX), or a molecularly imprinted catalyst (MIC). Then, a current proportional to the concentration of HbA1c can be produced. In this paper, we review a variety of representative electrochemical HbA1c sensors developed in recent years and elaborate on their operational principles, performance, and promising future clinical applications.

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“…Currently, POCT methods and devices are solely needed, but suffer from much Biosensors 2021, 11, 118 2 of 11 more non-specific adsorption than laboratory tests because samples are often used without pretreatment in POCT [17]. Although a number of nanocomposite-based sensors have been developed for the detection of HbA1c [18][19][20][21][22], a high abundance of interfering components such as non-glycated hemoglobin (HbAo) or serum proteins in clinical matrices can greatly interfere with detection results. Thus, anti-biofouling must be considered [17,23,24].…”

Section: Introductionmentioning

confidence: 99%

A Carbon-Based Antifouling Nano-Biosensing Interface for Label-Free POCT of HbA1c

Dou

et al. 2021

Biosensors

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Electrochemical biosensing relies on electron transport on electrode surfaces. However, electrode inactivation and biofouling caused by a complex biological sample severely decrease the efficiency of electron transfer and the specificity of biosensing. Here, we designed a three-dimensional antifouling nano-biosensing interface to improve the efficiency of electron transfer by a layer of bovine serum albumin (BSA) and multi-walled carbon nanotubes (MWCNTs) cross-linked with glutaraldehyde (GA). The electrochemical properties of the BSA/MWCNTs/GA layer were investigated using both cyclic voltammetry and electrochemical impedance to demonstrate its high-efficiency antifouling nano-biosensing interface. The BSA/MWCNTs/GA layer kept 92% of the original signal in 1% BSA and 88% of that in unprocessed human serum after a 1-month exposure, respectively. Importantly, we functionalized the BSA/MWCNTs/GA layer with HbA1c antibody (anti-HbA1c) and 3-aminophenylboronic acid (APBA) for sensitive detection of glycated hemoglobin A (HbA1c). The label-free direct electrocatalytic oxidation of HbA1c was investigated by cyclic voltammetry (CV). The linear dynamic range of 2 to 15% of blood glycated hemoglobin A (HbA1c) in non-glycated hemoglobin (HbAo) was determined. The detection limit was 0.4%. This high degree of differentiation would facilitate a label-free POCT detection of HbA1c.

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Glycated hemoglobin biosensing integration formed on Au nanoparticle-dotted tubular TiO2 nanoarray

Cited by 22 publications

References 37 publications

RETRACTED: Ultra-Sensitive Biosensor with Simultaneous Detection (of Cancer and Diabetes) and Analysis of Deformation Effects on Dielectric Rods in Optical Microstructure

RETRACTED: Ultra-Sensitive Biosensor with Simultaneous Detection (of Cancer and Diabetes) and Analysis of Deformation Effects on Dielectric Rods in Optical Microstructure

A Review of Electrochemical Sensors for the Detection of Glycated Hemoglobin

A Carbon-Based Antifouling Nano-Biosensing Interface for Label-Free POCT of HbA1c

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