Glycated Hemoglobin Is Associated With the Growth Rate of Abdominal Aortic Aneurysms

Kristensen, Katrine Lawaetz; Dahl, Marie; Rasmussen, Lars Melholt; Lindholt, Jes Sanddal

doi:10.1161/atvbaha.116.308874

Cited by 44 publications

(37 citation statements)

References 35 publications

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“…Using the participant information collected from the VIVA (Viborg Vascular) randomized screening trials of the Central Denmark Region, Kristensen and colleagues reported that growth rates of AAA were inversely associated with concentrations of HbA1c. 25 This study provides insights that long-lasting elevated blood glucose concentrations impair progression of AAA in humans.…”

Section: Abdominal Aortic Aneurysmsmentioning

confidence: 90%

Aortic Aneurysms

Lü

Daugherty

2017

ATVB

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Section: Abdominal Aortic Aneurysmsmentioning

confidence: 90%

Aortic Aneurysms

Lü

Daugherty

2017

ATVB

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“…To the best of our knowledge, this is the first report that investigated the link between fructosamine and AAA. Other studies have explored the association between HbA1c, which reflects the glycaemic status over the past 3 months, and identified an inverse association between the growth rate of AAA and the level of HbA1c ( 16 , 28 ). Taken together, these results underline the negative association between long-term high plasma glucose concentrations and AAA diameter.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have previously addressed the link between hyperglycaemia on AAA development. An inverse correlation was found between fasting blood glucose and glycated haemoglobin A1c (reflecting long-term glucose concentrations) with AAA diameter ( 14 , 16 ). While the link between blood glucose concentration and AAA development is well described, the association between AAA and insulin resistance has never been explored.…”

Section: Introductionmentioning

confidence: 93%

Association of abdominal aortic aneurysm diameter with insulin resistance index

Lareyre¹,

Moratal

Zereg³

et al. 2018

Biochemia Medica

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IntroductionEpidemiological studies have highlighted a negative association between diabetes and abdominal aortic aneurysm (AAA). The aim of this study was to investigate the association between insulin resistance and AAA size.Materials and methodsThis prospective cross sectional monocentric study analysed fasting blood samples from 55 patients with AAA eligible for surgical repair. They were divided into 2 groups according to the median AAA diameter: diameter < 50 mm (N = 28) and diameter > 50 mm (N = 27). The median ages were respectively 73 years (62 - 79) and 72 years (67 - 81). Glucose and fructosamine concentrations were determined by spectrophotometry; insulin and C-peptide using chemiluminescent technology. Homeostasis model assessment 2 calculator was used to estimate insulin resistance index (HOMA2 IR).ResultsThere was no significant difference for fasting glucose concentration between the groups (6.1 vs. 5.9 mmol/L, P = 0.825). C-peptide and insulin concentrations, as well as HOMA2 IR index were significantly higher in patients with AAA > 50 mm (0.82 vs. 0.54 nmol/L, P = 0.012; 9 vs. 5 mU/L, P = 0.019 and 1.72 vs. 1.26, P = 0.028, respectively). No linear correlation was identified between AAA diameter and HOMA2 IR. Fructosamine concentration was lower in patients with AAA > 50 mm (225.5 vs. 251 μmol/L, P = 0.005) and negatively correlated with AAA diameter (r = - 0.54, P < 0.001).ConclusionThis study evidenced an association between AAA diameter and insulin resistance. Further studies are required to determine a causal link between insulin resistance and AAA development.

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“… 10 , 17 Besides, several studies highlighted lower growth rates of AAA in diabetic patients compared to controls. 11 , 13 , 18 , 19 In practice, the decision to treat AAA takes into consideration the risk of rupture. As large aortic diameter and high growth rate represent major risk factors of rupture, 7 it is not surprising that a negative association between DM and aneurysm rupture was identified.…”

Section: Diabetes and The Epidemiology Of Aortic Aneurysmmentioning

confidence: 99%

“… 8 In this regard, an inverse association between the growth rate of AAA and the level of HbA1c was found both in individuals with and without DM, suggesting a mechanistic relationship between long-lasting elevated blood glucose levels and AAA progression. 18 …”

Section: Glycaemic Parameters and Aortic Aneurysmmentioning

confidence: 99%

Diabetes and aortic aneurysm: current state of the art

Raffort

Lareyre

Clément

et al. 2018

Cardiovascular Research

135

102

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Aortic aneurysm is a life-threatening disease due to the risk of aortic rupture. The only curative treatment available relies on surgical approaches; drug-based therapies are lacking, highlighting an unmet need for clinical practice. Abdominal aortic aneurysm (AAA) is frequently associated with atherosclerosis and cardiovascular risk factors including male sex, age, smoking, hypertension, and dyslipidaemia. Thoracic aortic aneurysm (TAA) is more often linked to genetic disorders of the extracellular matrix and the contractile apparatus but also share similar cardiovascular risk factors. Intriguingly, a large body of evidence points to an inverse association between diabetes and both AAA and TAA. A better understanding of the mechanisms underlying the negative association between diabetes and aortic aneurysm could help the development of innovative diagnostic and therapeutic approaches to tackle the disease. Here, we summarize current knowledge on the relationship between glycaemic parameters, diabetes, and the development of aortic aneurysm. Cellular and molecular pathways that underlie the protective effect of diabetes itself and its treatment are reviewed and discussed, along with their potential implications for clinical translation.

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Glycated Hemoglobin Is Associated With the Growth Rate of Abdominal Aortic Aneurysms

Abstract: We found an inverse association between the growth rate of abdominal aortic aneurysms and the level of HbA1c, indicating that long-lasting elevated blood sugar impairs aneurysmal progression in individuals with and without known diabetes mellitus.

Cited by 44 publications

References 35 publications

Aortic Aneurysms

Aortic Aneurysms

Association of abdominal aortic aneurysm diameter with insulin resistance index

Diabetes and aortic aneurysm: current state of the art

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