Glycemic control affects progression of kidney disease in patients with type 2 diabetes mellitus

Dodhia, Shital; Barasara, Jigar D; Joshi, Varsha

doi:10.5455/ijmsph.2016.11072015192

Cited by 6 publications

(7 citation statements)

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“…The result of this study is consistent to the result of Dodhia et al who demonstrated that glycemic control can affect the progression of kidney disease in type 2 diabetes patients. 15 They found an inverse relation between HbA1c and eGFR. We also found a significant inverse relation in patients with HbA1c above 7%.…”

Section: Discussionmentioning

confidence: 97%

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A gender wise correlation analysis between glycated hemoglobin level and estimated glomerular filtration rate among type 2 diabetes patients

et al. 2021

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Background: Studies found inconsistent relationship between glycated hemoglobin (HbA1C) and estimated glomerular filtration rate (eGFR) in diabetes. Hence, population based studies are warranted. This study was aimed to find out the prevalence of good glycemic control and correlation of HbA1c level with eGFR in male and female type 2 diabetes patients. Methods: A cross sectional study was designed among type 2 diabetes patients. Medical records of patients’ in the inclusion criteria were abstracted for demographic characteristics, HbA1c and serum creatinine level. Patients were grouped into male and female and further sub grouped as with or without good glycemic control (HbA1c ≤ 7%). Data were statistically analyzed.Results: A total of 465 diabetes patients (186 males and 279 females) were included. Among the total, more female patients were in good glycemic (p=0.0008) control. Gender wise comparison showed that HbA1c level was statistically significant between male and female patients in age groups below 60 years (p<0.05). HbA1c level, at >7%, showed an inverse correlation with eGFR in both male (r=- 0.3208, p=0.0008) and female patients (r =-0.3680, p<0.0001). For every 1% rise in HbA1c, eGFR declined by 10 ml/min/1.73 m2 in males and 13 ml/min/1.73 m2 in females.Conclusions: More female patients were in good glycemic control. HbA1c level above 7% showed an inverse correlation with eGFR in both male and female patients. For every 1% rise in HbA1c, the eGFR declined by 10 ml/min/1.73 m2 in male and 13 ml/min/1.73 m2 in female patients.

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Section: Discussionmentioning

confidence: 97%

“…9 Dodhia et al demonstrated that HbA1c level was inversely correlated with eGFR in type 2 diabetes patients. 10 But studies were found inconsistent relationship between HbA1c and GFR. 11,12 This may be associated with difference in race and gender which emphasizes the need for population based studies.…”

Section: Introductionmentioning

confidence: 99%

A gender wise correlation analysis between glycated hemoglobin level and estimated glomerular filtration rate among type 2 diabetes patients

et al. 2021

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“…An observational cross-sectional study that involved patients with type-2 DM who were receiving concurrent treatment for diabetes and hypertension showed that the mean HbA1c level was significantly higher and eGFR was significantly lower in patients with baseline serum creatinine ≥1.2 mg/dL compared with patients with baseline serum creatinine <1.2 mg/dL. The results indicated that poor glycemic control leads to diabetic nephropathy [15]. The results are consistent with the data collected in the current study that indicated a high prevalence of diabetic nephropathy in the Indian population (20.73%).…”

Section: Discussionmentioning

confidence: 99%

A Cross-sectional Retrospective Analysis of Glycemic Burden and Nephropathy in an Indian Population and Formulation of a New Plan Using eGFR/HbA1c Grid Formation

Roy¹,

Bhattacharjee²

2019

Cureus

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Background Diabetes is a metabolic, non-communicable disease (NCD) that represents one of the major causes of morbidity and mortality worldwide. India has a huge burden of chronic kidney disease (CKD) that is associated with diabetes. Materials and methods Cross-sectional data were collected for a total of 241 patients from the authors’ clinic record. A new approach for the management of patients with diabetes was proposed using a grid system, where we need to consider the Hemoglobin A1C (HbA1c) and estimated glomerular filtration rate (eGFR) values of the patient and assign a zone (green, blue, orange or red) and subsequently decide an appropriate treatment according to the assigned zone. Results We found that 20.73% of patients had decreased eGFR and only 31.12% of patients achieved target HbA1c level. A high prevalence of diabetic nephropathy (20.73%) was observed in this study population. A statistically significant difference among the four groups (zones) with respect to age ( p <0.001), duration of diabetes ( p = 0.024), HbA1c ( p <0.001), and eGFR ( p <0.001) was found. Conclusion The burden of diabetes and nephropathy is high in low-income countries and can be easily assessed by applying simple tools such as the newly proposed HbA1c/eGFR grid system to identify high-risk and medium-risk patients and adopting treatment according to the assigned zone.

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“…Improvement in glycemic control, particularly early in the treatment is associated with reductions in the incidence of microvascular complications, including chronic kidney disease. [5] However, a study carried out in hemodialysis patients showed the relative risk of tunneled central venous catheters causing bacteremia in patients is approximately 10 times higher than the risk of bacteremia in patients with AV fistula. [6] Studies showed that S. aureus as the most frequent causative organism followed by E. coli in hemodialysis patients.…”

Section: Discussionmentioning

confidence: 99%

Intravenous catheter complications in hemodialysis

Volabailu

Delanthabettu²

2017

Natl J Physiol Pharm Pharmacol

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Background: Vascular access, still is a problem for hemodialysis. Venous catheters are commonly used for acute angioaccess during maintenance hemodialysis in acute renal failure and end-stage renal failure patients. However, the catheters are often complicated by mechanical or infectious complications which may result in morbidity and or premature removal of the catheter. Even though, there are various studies on central venous catheters used in hemodialysis in western countries less is documented in India. Aims and Objectives: Complications of intravenous catheter used during hemodialysis in our set up. Materials and Methods: This prospective study was conducted on 110 patients selected by random sampling in dialysis units of a government district hospital from October 2014 to September 2015. Patient age, sex, history, type of kidney disease, and associated conditions were also noted according to the pro forma. Date of intravenous catheter insertion, site of insertion, and insertion complications were noted. All patients were followed up until the day of catheter removal. Date of catheter removal, reason for catheter removal, and duration of catheter days were noted. Data were collected and tabulated. Result: Only 47.8% of patients suspected with infections showed bacterial growth in catheter tip culture. However, blood culture showed bacterial growth only in 19.6% of infection suspected patients. Blood culture reported 55.6% Staphylococcus aureus growth followed by Pseudomonas (22.2%), Escherichia coli, and Acinetobacter (11.15%) growth in samples collected from infection suspected dialysis patients. Conclusion: Fever due to infections is the most common cause for catheter removal.

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Glycemic control affects progression of kidney disease in patients with type 2 diabetes mellitus

Cited by 6 publications

References 0 publications

A gender wise correlation analysis between glycated hemoglobin level and estimated glomerular filtration rate among type 2 diabetes patients

A gender wise correlation analysis between glycated hemoglobin level and estimated glomerular filtration rate among type 2 diabetes patients

A Cross-sectional Retrospective Analysis of Glycemic Burden and Nephropathy in an Indian Population and Formulation of a New Plan Using eGFR/HbA1c Grid Formation

Intravenous catheter complications in hemodialysis

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