Glycerol as a new mobile phase modifier for green liquid chromatographic determination of ascorbic acid and glutathione in pharmaceutical tablets

Habib, Ahmed; Mabrouk, Mokhtar M.; Fekry, Marwa; Mansour, Fotouh R.

doi:10.1016/j.jpba.2022.114870

Cited by 30 publications

(11 citation statements)

References 25 publications

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“…In 2021, glycerol was used for the separation of four antiviral medicines under reversed-phase chromatographic conditions [49]. The same group of authors used this solvent as a mobile phase modifier for the determination of ascorbic acid and glutathione in tablets [50].…”

Section: Glycerolmentioning

confidence: 99%

“…Due to the higher viscosity, it is recommended for glycerol to be premixed with the water phase, followed by sonication. This step will reduce the pump load of the LC system and will facilitate the mixing process [49,50]. In addition, the issue with higher viscosity could be overcome with the use of higher column temperature, because this parameter has a significant impact on the column back pressure.…”

Section: Glycerolmentioning

confidence: 99%

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Green Strategies toward Eco-Friendly HPLC Methods in Pharma Analysis

Nakov¹,

Acevska²,

Brezovska³

et al. 2023

High Performance Liquid Chromatography - Recent Advances and Applications

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The global need for changing the processes in order to meet the green analytical chemistry (GAC) criteria is a great challenge for the pharmaceutical industry. High-performance liquid chromatography (HPLC), as one of the most frequently used techniques in various stages in the pharmaceutical industry, generates huge amounts of organic toxic waste. Therefore, the implementation of the GAC principles in pharma analysis is highly required. Although the number of published papers concerning green chromatography approaches is constantly increasing, the use of eco-friendly HPLC methods in the pharma industry has not been widely implemented. The reasons for this mainly include the need for adaptation of the conventional HPLC instruments, lack of time, lack of experience, or uncertainty of the analysts regarding fulfillment of the method criteria. In this chapter, an overview of green strategies that can be easily applied to conventional instruments for liquid chromatography (LC) in developing eco-friendly HPLC methods in pharma analysis is given. The aim is to emphasize that the green method development in pharma analysis can be easily accomplished and to encourage the analytical community in the pharmaceutical industry not only to develop but also to transfer the already established conventional HPLC methods into green ones.

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Section: Glycerolmentioning

confidence: 99%

Section: Glycerolmentioning

confidence: 99%

Green Strategies toward Eco-Friendly HPLC Methods in Pharma Analysis

Nakov¹,

Acevska²,

Brezovska³

et al. 2023

High Performance Liquid Chromatography - Recent Advances and Applications

View full text Add to dashboard Cite

show abstract

“…Routine analysis of AA has been carried out by various techniques, including titrimetry, 9 uorimetry, 10 ow injection analysis, 11 spectrophotometry, 12 chromatography, 13,14 and electrochemistry. [15][16][17][18][19][20] Among these, electroanalytical methods offer rapid analysis of AA at low cost coupled with simplicity.…”

Section: Introductionmentioning

confidence: 99%

A novel electrochemical aptasensor based on polyaniline and gold nanoparticles for ultrasensitive and selective detection of ascorbic acid

et al. 2023

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“…5,6 Therefore, it is important to effectively monitor the levels of GSH during disease diagnosis and food safety supervision. Many analytical methodologies were developed for monitoring GSH including HPLC/UV, 7 SERS, 8 voltammetry, 9 and colorimetry. 10 Among them, fluorescence-based analytical approaches have received the most interest because of their wide dynamic linearity, low detection limit, and simplicity.…”

Section: Introductionmentioning

confidence: 99%