Glycine and its derivatives catalyzed one-pot multicomponent synthesis of bioactive heterocycles

One‐Pot Three‐Component Synthesis of Biologically Promising Indenoquinoxaline Fused Spiroheterocycles Starting from 11H‐indeno[1,2‐b]quinoxalin‐11‐ones

“…In continuation of our strong interest about various bioactive heterocyclic or spiroheterocyclic scaffolds, [31–40] in the following sections we have discussed a series of one‐pot three‐component reaction protocols for the synthesis of structurally diverse spiroheterocycles involving 11 H ‐indeno[1,2‐ b ]quinoxalin‐11‐one as one of the starting reactant under various reaction conditions.…”

“…[25] Multi-component reaction strategy is considered as economical as well as one of the greenest tool to synthesize various heterocyclic compounds for its multiple advantages such as operational simplicity, reduction of purification processes, high atom economy, energy efficiency and many more. [26][27][28][29][30] In continuation of our strong interest about various bioactive heterocyclic or spiroheterocyclic scaffolds, [31][32][33][34][35][36][37][38][39][40] in the following sections we have discussed a series of one-pot three-component reaction protocols for the synthesis of structurally diverse spiroheterocycles involving 11H-indeno [1,2-b]quinoxalin-11-one as one of the starting reactant under various reaction conditions.…”

Mandelic acid catalyzed one-pot pseudo three-component synthesis of various trisubstituted methane derivatives at room temperature

“…Under these environmentally conscious days, metal-free organocatalysts have gained significant attention due to their environmental friendliness. [36][37][38][39][40][41][42][43][44][45] Recently, our research group has explored the catalytic efficacies of mandelic acid for various organic transformations. [46][47][48][49][50] In this communication we wish to report another simple and efficient mandelic acid catalyzed protocol for the synthesis of a series of structurally diverse tri-substituted methane derivatives viz., 5,5'-(arylmethylene)bis(6-amino-pyrimidine-2,4(1H,3H)diones) and 2,2'-(arylmethylene)bis(3-hydroxy-5,5-dimethylcyclohex-2-enones) in aqueous ethanol at room temperature (Scheme 1).…”