Glycogen metabolism reprogramming promotes inflammation in coal dust-exposed lung

Wang, Qianqian; Mu, Mingchun; Zou, Yuanjie; Deng, Songsong; Lu, Yuting; Li, Qinglong; Li, Zeyu; Tao, Huihui; Wang, Yun; Tao, Xinrong

doi:10.1016/j.ecoenv.2022.113913

Cited by 9 publications

(4 citation statements)

References 65 publications

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“…In parallel, we found an upregulation of cAMP producing enzymes ADCY2 and ADCY8, with a downregulation of UGP2, which contributes to glycogen synthesis. These results suggest an imbalance between astrocytic cAMP-and Cadependent signalling pathways, which along with the downregulation of glycogen synthesis may contribute to deficient glucose and lactate homeostasis in the BD brain 75,76 . Several of these pathways were also found altered in the DGE analysis of the Zandi et al dataset (Figure S2A) We then asked if upregulation of ADCY2 77 , which is also related to the genetic risk for BD may have a functional impact on astrocyte glucose metabolism.…”

Section: Astrocytes In Bd Show Transcriptomic Alterations Suggestive ...mentioning

confidence: 88%

Altered astrocytic and microglial homeostasis characterizes a decreased proinflammatory state in bipolar disorder

Amossé,

Tournier,

Badina

et al. 2023

Preprint

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Multiple lines of evidence point to peripheral immune alterations in bipolar disorder (BD) although the activity of brain immune mechanisms remain largely unexplored. To identify the cell type-specific immune alterations in the BD brain, we performed a proteomic and single nuclear transcriptomic analysis ofpostmortemcingulate cortex samples from BD and control subjects. Our results showed that genes associated to the genetic risk for BD are enriched in microglia and astrocytes. Transcriptomic alterations in microglia point to a reduced proinflammatory phenotype, associated to reduced resistance to oxidative stress and apoptosis, which was confirmed with immunohistochemical quantification of IBA1 density. Astrocytes show transcriptomic evidence of an imbalance of multiple metabolic pathways, extracellular matrix composition and downregulated immune signalling. These alterations are associated toADCY2andNCAN,two GWAS genes upregulated in astrocytes. Finally, cell-cell communication analysis prioritized upregulated SPP1-CD44 signalling to astrocytes as a potential regulator of the transcriptomic alterations in BD. Our results indicate that microglia and astrocytes are characterized by downregulated immune responses associated to a dysfunction of core mechanisms via which these cells contribute to brain homeostasis.

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Section: Astrocytes In Bd Show Transcriptomic Alterations Suggestive ...mentioning

confidence: 88%

Altered astrocytic and microglial homeostasis characterizes a decreased proinflammatory state in bipolar disorder

Amossé,

Tournier,

Badina

et al. 2023

Preprint

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“…Aberrant accumulation is known to be linked to neuronal degeneration and is frequently found in neurodegenerative diseases such as Parkinson’s disease, Alzheimer’s disease, or dementia [ 31 , 32 ]. Recent studies have highlighted the association between glycogen accumulation and exposure to environmental contaminants in different tissues, such as the lungs [ 33 ] or liver [ 34 ]. In our study, no aberrant quantities of glycogen were found in the VNSEs of mice housed in normal conditions, but confined conditions, with or without ammonia, seem to induce glycogen accumulation in this organ, suggesting possible cellular metabolism disorder.…”

Section: Discussionmentioning

confidence: 99%

Does the Environmental Air Impact the Condition of the Vomeronasal Organ? A Mouse Model for Intensive Farming

Mechin,

Pageat,

Boutry

et al. 2023

Animals

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Chemical communication in mammals is ensured by exchanging chemical signals through the vomeronasal organ (VNO) and its ability to detect pheromones. The alteration of this organ has been proven to impact animal life, participating in the onset of aggressive behaviors in social groups. To date, few studies have highlighted the possible causes leading to these alterations, and the farming environment has not been investigated, even though irritant substances such as ammonia are known to induce serious damage in the respiratory tract. The goal of this study was to investigate the environmental impact on the VNO structure. Thirty mice were split into three groups, one housed in normal laboratory conditions and the other two in confined environments, with or without the release of litter ammonia. VNOs were analyzed using histology and immunohistochemistry to evaluate the effect of different environments on their condition. Both restricted conditions induced VNO alterations (p = 0.0311), soft-tissue alteration (p = 0.0480), and nonsensory epithelium inflammation (p = 0.0024). There was glycogen accumulation (p < 0.0001), the olfactory marker protein was underexpressed (p < 0.0001), and Gαi2 positivity remained unchanged while Gαo expression was upregulated in confined conditions. VNO conditions seemed to worsen with ammonia, even if not always significantly. These murine model results suggest that the housing environment can strongly impact VNO conditions, providing novel insights for improving indoor farming systems.

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“…In the mice model, treatment with 2-DG (0.4% w/v in drinking water) reduces infltration of infammatory cells, infammatory signaling activation, oxidative stress, capillary damage in lungs [26], and reduced the BALF and serum [26]. 2-DG reduces the infammatory responses triggered by glycogen accumulation caused by coal dust because macrophages have reconstituted glycogen metabolism [27]. A study on dextran sulfate sodium-induced colitis-mouse (mouse model for infammatory bowel disease), alleviated laminarin-induced arthritis in the SKG mouse (model for human rheumatoid arthritis), LPS shock (model for a cytokine storm), and LPS-induced pulmonary infammation (model for COVID-19) suggested that 2-DG is efective for the treatment of various infammatory disease due to its capability to inhibit cytokine receptor glycosylation [28].…”

Section: Inhibition Of Infammationmentioning

confidence: 99%

2-Deoxy-D-Glucose: A Novel Pharmacological Agent for Killing Hypoxic Tumor Cells, Oxygen Dependence-Lowering in Covid-19, and Other Pharmacological Activities

Singh¹,

Gupta

Kumar

et al. 2023

Advances in Pharmacological and Pharmaceutical Sciences

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The nonmetabolizable glucose analog 2-deoxy-D-glucose (2-DG) has shown promising pharmacological activities, including inhibition of cancerous cell growth and N-glycosylation. It has been used as a glycolysis inhibitor and as a potential energy restriction mimetic agent, inhibiting pathogen-associated molecular patterns. Radioisotope derivatives of 2-DG have applications as tracers. Recently, 2-DG has been used as an anti-COVID-19 drug to lower the need for supplemental oxygen. In the present review, various pharmaceutical properties of 2-DG are discussed.

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Glycogen metabolism reprogramming promotes inflammation in coal dust-exposed lung

Cited by 9 publications

References 65 publications

Altered astrocytic and microglial homeostasis characterizes a decreased proinflammatory state in bipolar disorder

Altered astrocytic and microglial homeostasis characterizes a decreased proinflammatory state in bipolar disorder

Does the Environmental Air Impact the Condition of the Vomeronasal Organ? A Mouse Model for Intensive Farming

2-Deoxy-D-Glucose: A Novel Pharmacological Agent for Killing Hypoxic Tumor Cells, Oxygen Dependence-Lowering in Covid-19, and Other Pharmacological Activities

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