Glycyrrhizin and Long-Term Histopathologic Changes in a Murine Model of Asthma

Hocaoğlu, Arzu Babayiğit; Karaman, Özkan; Erge, Duygu; Erbil, Güven; Yılmaz, Osman; Bağrıyanık, Alper; Uzuner, Nevin

doi:10.1016/j.curtheres.2011.11.002

Cited by 37 publications

(22 citation statements)

References 28 publications

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“…Consistent with previous reports, our study demonstrated that GA could significantly alleviate the severity of asthma, including airway inflammation and hyperresponsiveness (Supplementary http://onlinelibrary.wiley.com/doi/10.1111/resp.12655/suppinfo). We provide new insights on GA regarding its anti‐inflammatory action by targeting costimulatory pathways.…”

Section: Discussionsupporting

confidence: 92%

Regulation of Th1/Th2 balance through OX40/OX40L signalling by glycyrrhizic acid in a murine model of asthma

Tang

et al. 2015

Respirology

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Section: Discussionsupporting

confidence: 92%

Regulation of Th1/Th2 balance through OX40/OX40L signalling by glycyrrhizic acid in a murine model of asthma

Tang

et al. 2015

Respirology

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“…Nevertheless, these drugs do not completely cure or modify the progression of asthma. The symptoms return once the treatment is terminated and further, continued use of these drugs may often lead to systemic and as well local side effects [3940]. Thus, identification of novel effective therapeutics is of immense clinical value.…”

Section: Discussionmentioning

confidence: 99%

Magnolol exerts anti-asthmatic effects by regulating Janus kinase-signal transduction and activation of transcription and Notch signaling pathways and modulating Th1/Th2/Th17 cytokines in ovalbumin-sensitized asthmatic mice

Huang

Han

et al. 2019

Korean J Physiol Pharmacol

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Allergic asthma, is a common chronic inflammatory disease of the airway presenting with airway hyperresponsiveness and airway remodelling. T helper cells-derived cytokines are critically associated with asthma pathogenesis. Janus kinase-signal transduction and activation of transcription (JAK/STAT) signaling is found to be involved in asthma. Magnolol is a plant-derived bioactive compound with several pharmacological effects. The study aimed to assess the effects of magnolol in ovalbumin (OVA)-induced asthmatic model. BALB/c mice were sensitized and challenged with OVA. Magnolol (12.5, 25, or 50 mg/kg body weight) was administered to separate groups of animals. Dexamethasone was used as the positive control. Cellular infiltration into the bronchoalveolar lavage fluid (BALF) were reduced on magnolol treatment. The levels of Th2 and Th17 cytokines were reduced with noticeably raised levels of interferon gamma. Lung function was improved effectively along with restoration of bronchial tissue architecture. OVA-specific immunoglobulin E levels in serum and BALF were decreased by magnolol. Magnolol reduced Th17 cell population and effectively modulated the JAK-STAT and Notch 1 signaling. The results suggest the promising use of magnolol in therapy for allergic asthma.

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“…Glycyrrhizin (10 mg/kg, 7 days, p.o.) has beneficial effects on long-term histopathological changes to the respiratory airway in a mouse model of chronic ovalbumin (OVA)-induced asthma (Hocaoglu et al, 2011). In addition, Ma et al (2013) demonstrated that glycyrrhizic acid could suppress IL-4, IL-5, IL-13, and IFN-γ and inhibit both the recruitment of eosinophils and mucus overproduction in mice treated with OVA (Ma et al, 2013).…”

Section: Respiratory Studiesmentioning

confidence: 99%

Pharmacological Effects ofGlycyrrhizaspp. and Its Bioactive Constituents: Update and Review

2015

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The roots and rhizomes of various species of the perennial herb licorice (Glycyrrhiza) are used in traditional medicine for the treatment of several diseases. In experimental and clinical studies, licorice has been shown to have several pharmacological properties including antiinflammatory, antiviral, antimicrobial, antioxidative, antidiabetic, antiasthma, and anticancer activities as well as immunomodulatory, gastroprotective, hepatoprotective, neuroprotective, and cardioprotective effects. In recent years, several of the biochemical, molecular, and cellular mechanisms of licorice and its active components have also been demonstrated in experimental studies. In this review, we summarized the new phytochemical, pharmacological, and toxicological data from recent experimental and clinical studies of licorice and its bioactive constituents after our previous published review.

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Glycyrrhizin and Long-Term Histopathologic Changes in a Murine Model of Asthma

Abstract: The results of this study suggest that the group receiving glycyrrhizin had amelioration of all established chronic histopathologic changes of lung in the mouse model of asthma. Further studies are needed to evaluate the efficacy of glycyrrhizin in the management of asthma.

Cited by 37 publications

References 28 publications

Regulation of Th1/Th2 balance through OX40/OX40L signalling by glycyrrhizic acid in a murine model of asthma

Regulation of Th1/Th2 balance through OX40/OX40L signalling by glycyrrhizic acid in a murine model of asthma

Magnolol exerts anti-asthmatic effects by regulating Janus kinase-signal transduction and activation of transcription and Notch signaling pathways and modulating Th1/Th2/Th17 cytokines in ovalbumin-sensitized asthmatic mice

Pharmacological Effects ofGlycyrrhizaspp. and Its Bioactive Constituents: Update and Review

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