Glyphosate based- herbicide exposure affects gut microbiota, anxiety and depression-like behaviors in mice

Ait-Bali, Yassine; Ba‐M’hamed, Saadia; Elhidar, Najoua; Nafis, Ahmed; Soraa, Nabila; Bennis, Mohamed

doi:10.1016/j.ntt.2018.04.002

Cited by 155 publications

(119 citation statements)

References 33 publications

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“…Evidence for this notion is provided by, for example, a recent report using an AD-like pathology with amyloid and neurofibrillary tangles (ADLPAPT) transgenic mouse model of AD [162], whereby transplantation of fecal microbiota from wild-type mice into ADLPAPT mice ameliorated plaque and NFT formation, reduced glial activation, and alleviated cognitive impairment [163]. A number of reports have now indicated that a wide range of pesticides, such as the fungicide propamocarb [164], glyphosate herbicides [165], carbamate insecticide Aldicarb [166], and Chlorpyrifos [167,168] are all known to alter gut microbiota and cause varying degrees of dysbiosis. Exposure of propamocarb to mice at 3-300 mg/L through drinking water for a duration of 28 days changed the microbiota in the cecal and fecal contents at phylum or genus levels [164].…”

Section: Dysfunction Of the Brain-gut Axismentioning

confidence: 99%

Neuropathological Mechanisms Associated with Pesticides in Alzheimer’s Disease

Tang

2020

Toxics

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Environmental toxicants have been implicated in neurodegenerative diseases, and pesticide exposure is a suspected environmental risk factor for Alzheimer’s disease (AD). Several epidemiological analyses have affirmed a link between pesticides and incidence of sporadic AD. Meanwhile, in vitro and animal models of AD have shed light on potential neuropathological mechanisms. In this paper, a perspective on neuropathological mechanisms underlying pesticides’ induction of AD is provided. Proposed mechanisms range from generic oxidative stress induction in neurons to more AD-specific processes involving amyloid-beta (Aβ) and hyperphosphorylated tau (p-tau). Mechanisms that are more speculative or indirect in nature, including somatic mutation, epigenetic modulation, impairment of adult neurogenesis, and microbiota dysbiosis, are also discussed. Chronic toxicity mechanisms of environmental pesticide exposure crosstalks in complex ways and could potentially be mutually enhancing, thus making the deciphering of simplistic causal relationships difficult.

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Section: Dysfunction Of the Brain-gut Axismentioning

confidence: 99%

Neuropathological Mechanisms Associated with Pesticides in Alzheimer’s Disease

Tang

2020

Toxics

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“…Indeed, GBH induced alteration in neurotransmitter dopamine, norepinephrine, serotonin and glutamate levels and their metabolites in several brain regions, such as the hippocampus, substantia nigra and prefrontal cortex in adult male rats, as well as neurotransmitter binding to their cognate receptor . Consequently, these alterations in neurotransmission are likely to be the cause of deficits in locomotor activity and depressive‐ and anxiety‐like symptoms observed in male mice and male and female rats following glyphosate exposure . Interestingly, although several studies have investigated the effect of perinatal exposure to GBH via the exposure to gestating and lactating females, there is no information about the mother's behaviour and brain plasticity and how the dam herself could be affected by the treatment.…”

Section: Introductionmentioning

confidence: 99%

“…is known to be associated with significant alterations of the organism's physiology, including defect in brain neurodevelopment and neuroplasticity . Recently, a few studies showed that GBH exposure can affect gut microbiota, a process known as dysbiosis and that such an alteration could result in mental health disorders, including anxiety and depression . Alternatively, or in addition, glyphosate possess chelating properties and binds divalent cations (e.g.…”

Section: Introductionmentioning

confidence: 99%

“…23 Consequently, these alterations in neurotransmission are likely to be the cause of deficits in locomotor activity and depressive-and anxiety-like symptoms observed in male mice and male and female rats following glyphosate exposure. [24][25][26][27] Interestingly, although several studies have investigated the effect of perinatal exposure to GBH via the exposure to gestating and lactating females, there is no information about the mother's behaviour and brain plasticity and how the dam herself could be affected by the treatment.…”

mentioning

confidence: 99%

“…[44][45][46] Recently, a few studies showed that GBH exposure can affect gut microbiota, a process known as dysbiosis 40,[47][48][49] and that such an alteration could result in mental health disorders, including anxiety and depression. 24,25 Alternatively, or in addition, glyphosate possess chelating properties and binds divalent cations (e.g.…”

mentioning

confidence: 99%

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Glyphosate and glyphosate‐based herbicide exposure during the peripartum period affects maternal brain plasticity, maternal behaviour and microbiome

Dechartres

Pawluski

Guéguen

et al. 2019

J Neuroendocrinology

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Glyphosate is found in a large array of non‐selective herbicides such as Roundup® (Monsanto, Creve Coeur, MO, USA) and is by far the most widely used herbicide. Recent work in rodent models suggests that glyphosate‐based herbicides during development can affect neuronal communication and result in altered behaviours, albeit through undefined mechanisms of action. To our knowledge, no study has investigated the effects glyphosate or its formulation in herbicide on maternal behaviour and physiology. In the present study, relatively low doses of glyphosate (5 mg kg‐1 d‐1), Roundup® (5 mg kg‐1 d‐1 glyphosate equivalent), or vehicle were administered by ingestion to Sprague‐Dawley rats from gestational day (GD) 10 to postpartum day (PD)22. The treatments significantly altered licking behaviour toward pups between PD2 and PD6. We also show in the dams at PD22 that Roundup exposure affected the maturation of doublecortin‐immunoreactive new neurones in the dorsal dentate gyrus of the hippocampus of the mother. In addition, the expression of synaptophysin was up‐regulated by glyphosate in the dorsal and ventral dentate gyrus and CA3 regions of the hippocampus, and down‐regulated in the cingulate gyrus. Although a direct effect of glyphosate alone or its formulation on the central nervous system is currently not clear, we show that gut microbiota is significantly altered by the exposure to the pesticides, with significant alteration of the phyla Bacteroidetes and Firmicutes. This is the first study to provide evidence that glyphosate alone or in formulation (Roundup) differentially affects maternal behaviour and modulates neuroplasticity and gut microbiota in the mother.

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Behavioral and neuroinflammatory changes caused by glyphosate: Base herbicide in mice offspring

Carneiro

Chaves

Neves

et al. 2022

Birth Defects Research

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Background: Glyphosate is a pesticide considered of low toxicity, but scientific evidences show it can be harmful to health. This study aimed to evaluate the toxicity in mice offspring exposed to glyphosate-based herbicide (GBH) during the intrauterine period. Methods: Female matrices received glyphosate 0.3 mg/kg daily per oral throughout the gestational period, which was variable between 18 and 22 days.From the 25th until the 28th days post-birth, mice offspring were subjected to behavioral tests, and the prefrontal cortex was processed for immunohistochemical analysis. Results: Two significant behavioral changes were observed: anxiety in the GLIF0.3 group, increase in the behavior burying marbles in the marbleburying test and hyperactivity, expressed by the significant increase of the crossing number in the open field test. The increased microglia, TNF-alpha, and astrocyte expression were also observed in the prefrontal cortex of offspring treated with GLIF0.3. Conclusion:Exposure to GBH during mice intrauterine development induces hyperactive and anxious behavior, evidencing neuroinflammation.

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Glyphosate based- herbicide exposure affects gut microbiota, anxiety and depression-like behaviors in mice

Cited by 155 publications

References 33 publications

Neuropathological Mechanisms Associated with Pesticides in Alzheimer’s Disease

Neuropathological Mechanisms Associated with Pesticides in Alzheimer’s Disease

Glyphosate and glyphosate‐based herbicide exposure during the peripartum period affects maternal brain plasticity, maternal behaviour and microbiome

Behavioral and neuroinflammatory changes caused by glyphosate: Base herbicide in mice offspring

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