Glyphosate exposure modulates lipid composition, histo-architecture and oxidative stress status and induces neurotoxicity in the smooth scallop Flexopecten glaber

Telahigue, Khaoula; Rabeh, Imen; Mhadhbi, Lazhar; Nechi, Salwa; Chelbi, Emna; Ali, Manel Ben; Hedfi, Amor; AL-Harbi, Mohammad S.; Hajji, Tarek

doi:10.1016/j.pestbp.2022.105099

Cited by 13 publications

(10 citation statements)

References 76 publications

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“…Mussels exposed to the most Gly (10 mg/L) at 20 °C showed the highest level of SFA (49% of total FAs, Table 1 ), due to the increased proportions of stearic (C18:0) and palmitic (C16:0) acids. Similarly, Telahigue [ 38 ] reported an enhanced saturation level in the digestive gland of F. glaber exposed to Gly at 18 ± 1 °C.…”

Section: Resultsmentioning

confidence: 79%

“…In the same way, exposure to Gly caused a significant increase in MUFA compared with CTRs in this study ( p < 0.05, Figure 2 , Table 1 and Table 2 ). Similarly, enhanced levels of MUFA have been found in the gills of F. glaber exposed to Gly at 18 ± 1 °C [ 38 ].…”

Section: Resultsmentioning

confidence: 92%

“…In most of them, glyphosate can induce oxidative stress and DNA damage, inhibit enzymatic activities, and affect energy metabolism and growth rates [ 32 , 33 ]. Recent scientific data report the involvement of pesticides in the lipid composition modulation of aquatic organisms, although few studies have been conducted on bivalves [ 34 , 35 , 36 , 37 , 38 ]. Telahigue [ 38 ] investigated the toxic effect of Gly on scallops Flexopecten glaber in which they reported an altered FA profile.…”

Section: Introductionmentioning

confidence: 99%

“…Recent scientific data report the involvement of pesticides in the lipid composition modulation of aquatic organisms, although few studies have been conducted on bivalves [ 34 , 35 , 36 , 37 , 38 ]. Telahigue [ 38 ] investigated the toxic effect of Gly on scallops Flexopecten glaber in which they reported an altered FA profile.…”

Section: Introductionmentioning

confidence: 99%

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Can Glyphosate and Temperature Affect the Nutritional Lipid Quality in the Mussel Mytilus galloprovincialis?

Biandolino

Prato

Grattagliano

et al. 2023

Foods

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Mussels are an important source of the essential omega-3 polyunsaturated fatty acids (n-3 PUFAs), which play a critical role in human health, preventing a variety of diseases. This study aimed to evaluate, for the first time, the combined effect of glyphosate (Gly) and culturing temperature on the lipid content and fatty acid (FA) profile of the Mediterranean mussel M. galloprovincialis. In addition, a number of lipid nutritional quality indices (LNQIs) were applied as important tools to assess the nutritional value of food. Mussels were exposed for 4 days to two Gly concentrations (1 mg/L, 10 mg/L) and two temperatures (T°: 20–26 °C). Statistical analysis showed significant effects of T°C, Gly, and T°C × Gly interaction (p < 0.05) on the lipid and FA profiles of M. galloprovincialis. Mussels exposed to 10 mg/L Gly at 20 °C showed a decrease in eicosapentaenoic (EPA, from 14.6% to 12% of total FAs) and docosahexaenoic acids (DHA, from 10% to 6.4% of total FAs), compared to the control mussels. Both stressors caused a considerable decrease in n-3 PUFAs, which resulted in a less favorable n-6/n-3 PUFA ratio. Overall, this study demonstrated a decline in the nutritive values of mussels, most prominently in groups exposed to 10 mg/L Gly at a temperature of 20 °C and in those exposed to a temperature of 26 °C. This was confirmed by such LNQIs as EPA + DHA, PUFA/Saturated FAs, atherogenic and thrombogenic indices (AI and TI), the health promoting index (HPI), and the unsaturation index (UI). Further investigations into chronic exposure to both stressors are desirable to predict the impacts on aquatic ecosystems and food quality.

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Section: Resultsmentioning

confidence: 79%

Section: Resultsmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Can Glyphosate and Temperature Affect the Nutritional Lipid Quality in the Mussel Mytilus galloprovincialis?

Biandolino

Prato

Grattagliano

et al. 2023

Foods

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“…Antioxidant enzymes play the most important role in cellular protection against oxidative stress, with the SOD–CAT–GSH-PX enzyme cascade serving as the first line of defense against ROS [ 38 , 39 ]. Salinity increases have previously been shown to cause behavioral changes, mortality, and induction of antioxidant enzymes in a variety of euryhaline freshwater fish species [ 40 , 41 , 42 , 43 ]. In the present study, salinity stress significantly increased the activity of antioxidant enzymes (SOD, CAT) in the gill tissues of silver carp.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Salinity Stress on Enzyme Activities, Histology, and Transcriptome of Silver Carp (Hypophthalmichthys molitrix)

Jiang

Yuan

et al. 2022

Biology

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A 56-day study was performed to examine the effect of freshwater (FW) and brackish water (BW 6‰ salinity) on the antioxidant ability, Na+/K+-ATPase (NKA) activities, histology, and transcriptome of the gill and kidney tissue in juvenile silver carp (Hypophthalmichthys molitrix). The results show that when juvenile silver carp were exposed to 6‰ salinity, the activities of superoxide dismutase (SOD) and catalase (CAT) were shown to be substantially increased (p < 0.05), while glutathione peroxidase (GSH-PX) activities in gill were not significantly affected (p < 0.05). In kidney tissue, SOD, CAT, and GSH-PX, enzyme activities peaked at 24, 8, and 4 h, respectively, but were not significantly different compared with the control group (p < 0.05). In addition, significant effects of salinity were observed for the NKA level in both the gills and kidney tissues (p < 0.05). The gill filaments of juvenile silver carp under the BW group all underwent adverse changes within 72 h, such as cracks and ruptures in the main part of the gill filaments, bending of the gill lamellae and enlargement of the gaps, and an increase in the number of mucus and chloride-secreting cells. Transcriptome sequencing showed 171 and 261 genes in the gill and kidney tissues of juvenile silver carp compared to the BW group, respectively. Based on their gene ontology annotations, transcripts were sorted into four functional gene groups, each of which may play a role in salt tolerance. Systems involved in these processes include metabolism, signal transduction, immunoinflammatory response, and ion transport. The above findings indicate that the regulation processes in juvenile silver carp under brackish water conditions are complex and multifaceted. These processes and mechanisms shed light on the regulatory mechanism of silver carp osmolarity and provide a theoretical foundation for future research into silver carp growth in brackish water aquaculture area.

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Cultivation of Chlorella sorokiniana in indoor and outdoor raceway ponds under glyphosate stress for bioproduct production

Arora,

Bisht,

Thakur

et al. 2023

Biomass Conv. Bioref.

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Glyphosate exposure modulates lipid composition, histo-architecture and oxidative stress status and induces neurotoxicity in the smooth scallop Flexopecten glaber

Cited by 13 publications

References 76 publications

Can Glyphosate and Temperature Affect the Nutritional Lipid Quality in the Mussel Mytilus galloprovincialis?

Can Glyphosate and Temperature Affect the Nutritional Lipid Quality in the Mussel Mytilus galloprovincialis?

The Effect of Salinity Stress on Enzyme Activities, Histology, and Transcriptome of Silver Carp (Hypophthalmichthys molitrix)

Cultivation of Chlorella sorokiniana in indoor and outdoor raceway ponds under glyphosate stress for bioproduct production

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