Glyphosate skin binding, absorption, residual tissue distribution, and skin decontamination

Wester, Ronald C.; Melendres, Joseph; Sarason, R. L.; Mcmaster, James A.; Maibach, Howard I.

doi:10.1016/0272-0590(91)90158-z

Cited by 54 publications

(31 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Inhalation of spray droplets was found to be a minor route of glyphosate exposure in a study of glyphosate applicators in Finland (Jauhiainen et al 1991), leaving dermal contact as the primary route of exposure. Dermal penetration experiments, where glyphosate was left undisturbed on skin surfaces of experimental animals and on human skin in vitro, indicate a percutaneous absorption of less than 2% (Wester et al 1991).…”

Section: Biomonitoring Studies Implications For Exposure Assessmentmentioning

confidence: 99%

Glyphosate epidemiology expert panel review: a weight of evidence systematic review of the relationship between glyphosate exposure and non-Hodgkin’s lymphoma or multiple myeloma

Acquavella

Garabrant

Marsh

et al. 2016

Critical Reviews in Toxicology

View full text Add to dashboard Cite

We conducted a systematic review of the epidemiologic literature for glyphosate focusing on nonHodgkin's lymphoma (NHL) and multiple myeloma (MM) -two cancers that were the focus of a recent review by an International Agency for Research on Cancer Working Group. Our approach was consistent with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines for systematic reviews. We evaluated each relevant study according to a priori criteria for study quality: adequacy of study size, likelihood of confounding, potential for other biases and adequacy of the statistical analyses. Our evaluation included seven unique studies for NHL and four for MM, all but one of which were case control studies for each cancer. For NHL, the case-control studies were all limited by the potential for recall bias and the lack of adequate multivariate adjustment for multiple pesticide and other farming exposures. Only the Agricultural Health (cohort) Study met our a priori quality standards and this study found no evidence of an association between glyphosate and NHL. For MM, the case control studies shared the same limitations as noted for the NHL case-control studies and, in aggregate, the data were too sparse to enable an informed causal judgment. Overall, our review did not find support in the epidemiologic literature for a causal association between glyphosate and NHL or MM. ARTICLE HISTORY

show abstract

Section: Biomonitoring Studies Implications For Exposure Assessmentmentioning

confidence: 99%

Glyphosate epidemiology expert panel review: a weight of evidence systematic review of the relationship between glyphosate exposure and non-Hodgkin’s lymphoma or multiple myeloma

Acquavella

Garabrant

Marsh

et al. 2016

Critical Reviews in Toxicology

View full text Add to dashboard Cite

show abstract

“…Glyphosate is soluble in water and has low affinity for organic materials such as skin. Dermal penetration experiments, where glyphosate was left undisturbed on skin surfaces of experimental animals and on human skin in vitro, indicate a percutaneous absorption of less than 2% (Wester et al 1991). The experimental conditions for the skin penetration studies were developed to maximize absorption, so actual human percutaneous absorption may be less.…”

Section: Discussionmentioning

confidence: 99%

“…Wester et al (1991) conducted a pharmacokinetic study of glyphosate with monkeys using intravenous dosing and were able to recover approximately 95% of the administered glyphosate. We divided S 1 by 0.95 to estimate of the amount of glyphosate that would have been recovered in urine with complete pharmacokinetic recovery (S 2 ).…”

Section: Methodsmentioning

confidence: 99%

Glyphosate biomonitoring for farmers and their families: results from the Farm Family Exposure Study.

Acquavella

Alexander

Mandel

et al. 2004

Environ Health Perspect

270

203

View full text Add to dashboard Cite

Glyphosate is the active ingredient in Roundup agricultural herbicides and other herbicide formulations that are widely used for agricultural, forestry, and residential weed control. As part of the Farm Family Exposure Study, we evaluated urinary glyphosate concentrations for 48 farmers, their spouses, and their 79 children (4-18 years of age). We evaluated 24-hr composite urine samples for each family member the day before, the day of, and for 3 days after a glyphosate application. Sixty percent of farmers had detectable levels of glyphosate in their urine on the day of application. The geometric mean (GM) concentration was 3 ppb, the maximum value was 233 ppb, and the highest estimated systemic dose was 0.004 mg/kg. Farmers who did not use rubber gloves had higher GM urinary concentrations than did other farmers (10 ppb vs. 2.0 ppb). For spouses, 4% had detectable levels in their urine on the day of application. Their maximum value was 3 ppb. For children, 12% had detectable glyphosate in their urine on the day of application, with a maximum concentration of 29 ppb. All but one of the children with detectable concentrations had helped with the application or were present during herbicide mixing, loading, or application. None of the systemic doses estimated in this study approached the U.S. Environmental Protection Agency reference dose for glyphosate of 2 mg/kg/day. Nonetheless, it is advisable to minimize exposure to pesticides, and this study did identify specific practices that could be modified to reduce the potential for exposure.

show abstract

“…A first peak 5 h after exposure could be explained by a rapid inhalatory or oral route [6] followed by elimination of detectable compounds. The second detectable increase, 24 h later, could be linked to dermal absorption [7] of a small part of the pesticide applied. This may explain the different intensity of the two times of excretions with different absorption rates of the pesticide [8].…”

Section: Discussionmentioning

confidence: 99%

Glyphosate Exposure in a Farmer’s Family

Mesnage¹,

Mœsch²,

Grand³

et al. 2012

JEP

View full text Add to dashboard Cite

We tested the presence of glyphosate in the urines of a farmer who sprayed a glyphosate based herbicide on his land, and in his family, as his children were born with birth defects that could be due to or promoted by pesticides. Glyphosate residues were measured in urines a day before, during, and two days after spraying, by liquid chromatography-linear ion trap mass spectrometry. Glyphosate reached a peak of 9.5 µg/L in the farmer after spraying, and 2 µg/L were found in him and in one of his children living at a distance from the field, two days after the pulverization. Oral or dermal absorptions could explain the differential pesticide excretions, even in family members at a distance from the fields. A more detailed following of agricultural practices and family exposures should be advocated together with information and recommendations.

show abstract

Glyphosate skin binding, absorption, residual tissue distribution, and skin decontamination

Cited by 54 publications

References 6 publications

Glyphosate epidemiology expert panel review: a weight of evidence systematic review of the relationship between glyphosate exposure and non-Hodgkin’s lymphoma or multiple myeloma

Glyphosate epidemiology expert panel review: a weight of evidence systematic review of the relationship between glyphosate exposure and non-Hodgkin’s lymphoma or multiple myeloma

Glyphosate biomonitoring for farmers and their families: results from the Farm Family Exposure Study.

Glyphosate Exposure in a Farmer’s Family

Contact Info

Product

Resources

About