Gm Allotyping to Determine the Origin of Red Cell Antibodies in Recipients of Solid Organ Transplants

Abstract

Alloantibodies of A and B specificity were detected in the serum and on the red cells of 4 non-0 recipients of group 0 solid organ transplants. The antibodies were assumed to be produced by 'passenger' lymphocytes introduced at the time of transplant. Gm allotyping of donor serums, recipient serums and the unexpected antibodies was done. Gm typing was informative in 1 case, when the anti-A1 found in the serum of a liver transplant recipient was shown to be of phenotype Gm(fb) and the Gm phenotype of the recipient to be Gm(axg). Gm allotyping was not informative in the other 3 cases.

Gm Allotyping to Determine the Origin of the Anti‐D Causing Hemolytic Anemia in a Kidney Transplant Recipient

“…The ABO and Rh alloantibodies detected after transplantation have been assumed to be made by passenger lymphocytes transplanted with the donor organ [ 1-1 71 and one example was shown to be donor derived by Gm typing [17]. Gm typing was useful in the case now described since the mother's Gm typing was not identical to her son's and the antibody found in the posttransplantation serum was clearly of maternal origin.…”