GM-CSF is not essential for optimal fertility or for weight control

Hamilton, John A.; Davis, Jennifer; Pobjoy, Jarrad; Cook, Andrew D.

doi:10.1016/j.cyto.2011.10.021

Cited by 6 publications

(2 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…47 Consistent with previous studies, 48 the GM-CSF -/-and WT strains did not differ in body weight and appeared in good overall health, and there were no apparent differences between WT and GM-CSF -/-sham-injured groups. Nonetheless, it is possible that compensatory effects, particularly related to inflammatory and hematopoietic factors, might occur in this mouse strain.…”

Section: Role Of Gm-csf In Tbisupporting

confidence: 78%

Granulocyte-Macrophage Colony-Stimulating Factor Is Neuroprotective in Experimental Traumatic Brain Injury

Shultz

Tan

Wright

et al. 2014

Journal of Neurotrauma

Self Cite

View full text Add to dashboard Cite

Traumatic brain injury (TBI) is an international health concern with a complex pathogenesis resulting in major long-term neurological, neurocognitive, and neuropsychiatric outcomes. Although neuroinflammation has been identified as an important pathophysiological process resulting from TBI, the function of specific inflammatory mediators in the aftermath of TBI remains poorly understood. Granulocyte-macrophage colony-stimulating factor (GM-CSF) is an inflammatory cytokine that has been reported to have neuroprotective effects in various animal models of neurodegenerative disease that share pathological similarities with TBI. The importance of GM-CSF in TBI has yet to be studied, however. We examined the role of GM-CSF in TBI by comparing the effects of a lateral fluid percussion (LFP) injury or sham injury in GM-CSF gene deficient (GM-CSF -/-) versus wild-type (WT) mice. After a 3-month recovery interval, mice were assessed using neuroimaging and behavioral outcomes. All mice given a LFP injury displayed significant brain atrophy and behavioral impairments compared with those given sham-injuries; however, this was significantly worse in the GM-CSF -/-mice compared with the WT mice. GM-CSF -/-mice given LFP injury also had reduced astrogliosis compared with their WT counterparts. These novel findings indicate that the inflammatory mediator, GM-CSF, may have significant protective properties in the chronic sequelae of experimental TBI and suggest that further research investigating GM-CSF and its potential benefits in the injured brain is warranted.

show abstract

Section: Role Of Gm-csf In Tbisupporting

confidence: 78%

Granulocyte-Macrophage Colony-Stimulating Factor Is Neuroprotective in Experimental Traumatic Brain Injury

Shultz

Tan

Wright

et al. 2014

Journal of Neurotrauma

Self Cite

View full text Add to dashboard Cite

show abstract

“…Ϫ/Ϫ mice have either normal body weight when fed a low fat diet or increased body weight when fed a high fat diet compared with wild-type littermate controls (29,30). However, both reports failed to report adiposity.…”

Section: Gm-csf Induces Increased Fat Mass In Young Mice and The Effmentioning

confidence: 76%

Granulocyte/Macrophage Colony-stimulating Factor-dependent Dendritic Cells Restrain Lean Adipose Tissue Expansion

Pamir¹,

Liu²,

Irwin³

et al. 2015

Journal of Biological Chemistry

View full text Add to dashboard Cite

Suppressed expression of granulocyte macrophage colony-stimulating factor in oviduct ampullae of obese cows

Nahar

Maki

Kadokawa

2013

Animal Reproduction Science

View full text Add to dashboard Cite

GM-CSF is not essential for optimal fertility or for weight control

Cited by 6 publications

References 14 publications

Granulocyte-Macrophage Colony-Stimulating Factor Is Neuroprotective in Experimental Traumatic Brain Injury

Granulocyte-Macrophage Colony-Stimulating Factor Is Neuroprotective in Experimental Traumatic Brain Injury

Granulocyte/Macrophage Colony-stimulating Factor-dependent Dendritic Cells Restrain Lean Adipose Tissue Expansion

Suppressed expression of granulocyte macrophage colony-stimulating factor in oviduct ampullae of obese cows

Contact Info

Product

Resources

About