Gm15575 functions as a ceRNA to up-regulate CCL7 expression through sponging miR-686 in Th17 cells

Bian, Zhengying; Lei, Wen; Li, Qianwen; Xue, Wenyao; Gao, Yue; Zeng, Yu; Wang, Yimeng; Tang, Lei; Tang, Tiejun; Chen, Cong; Gao, Xiangdong; Guo, Wei

doi:10.1016/j.molimm.2020.06.027

Cited by 13 publications

(11 citation statements)

References 38 publications

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“…At last, 53 studies remained for our systematic review. Among the included studies, 47 studies were conducted on human samples ( 24 – 70 ), 7 studies used animal models ( 45 , 71 – 76 ), and only 1 research was conducted on both human samples and animal model ( 45 ). Also, 33 studies were conducted in the Iranian population ( 24 – 26 , 28 – 34 , 36 , 38 – 43 , 45 – 55 , 57 , 58 , 61 , 66 , 67 ), 9 studies were in China ( 68 – 76 ), 5 studies were in Egypt ( 37 , 62 – 65 ), 4 studies were in Italy ( 27 , 35 , 59 , 60 ), 1 study was in Russia ( 44 ), and 1 study was in the Netherlands ( 56 ).…”

Section: Resultsmentioning

confidence: 99%

Long Non-Coding RNAs, Novel Offenders or Guardians in Multiple Sclerosis: A Scoping Review

et al. 2021

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Multiple sclerosis (MS), a chronic inflammatory demyelinating disease of the central nervous system, is one of the most common neurodegenerative diseases worldwide. MS results in serious neurological dysfunctions and disability. Disturbances in coding and non-coding genes are key components leading to neurodegeneration along with environmental factors. Long non-coding RNAs (lncRNAs) are long molecules in cells that take part in the regulation of gene expression. Several studies have confirmed the role of lncRNAs in neurodegenerative diseases such as MS. In the current study, we performed a systematic analysis of the role of lncRNAs in this disorder. In total, 53 studies were recognized as eligible for this systematic review. Of the listed lncRNAs, 52 lncRNAs were upregulated, 37 lncRNAs were downregulated, and 11 lncRNAs had no significant expression difference in MS patients compared with controls. We also summarized some of the mechanisms of lncRNA functions in MS. The emerging role of lncRNAs in neurodegenerative diseases suggests that their dysregulation could trigger neuronal death via still unexplored RNA-based regulatory mechanisms. Evaluation of their diagnostic significance and therapeutic potential could help in the design of novel treatments for MS.

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Section: Resultsmentioning

confidence: 99%

Long Non-Coding RNAs, Novel Offenders or Guardians in Multiple Sclerosis: A Scoping Review

et al. 2021

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“…Hence, the expression of the corresponding mRNAs is regulated [32,33]. In terms of MS, the lncRNA, GM15575, was demonstrated to be involved in the progression of Th17 cell-associated MS by acting as a ceRNA to suppress miR-686 activity [34]. Sulfasalazine, an effective medicine for MS, could suppress microglia switching to a proinflammatory phenotype via the ceRNA effect of miR-136-5p and the lncRNA HOTAIR [35].…”

Section: Discussionmentioning

confidence: 99%

Identification of Novel Key Genes and Pathways in Multiple Sclerosis Based on Weighted Gene Coexpression Network Analysis and Long Noncoding RNA-Associated Competing Endogenous RNA Network

Hao

et al. 2022

Oxidative Medicine and Cellular Longevity

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Objective. Multiple sclerosis (MS) is an autoimmune disease of the central nervous system characterized by chronic inflammation and demyelination. This study is aimed at identifying crucial genes and molecular pathways involved in MS pathogenesis. Methods. Raw data in GSE52139 were collected from the Gene Expression Omnibus. The top 50% expression variants were subjected to weighted gene coexpression network analysis (WGCNA), and the key module associated with MS occurrence was identified. A long noncoding RNA- (lncRNA-) associated competing endogenous RNA (ceRNA) network was constructed in the key module. The hub gene candidates were subsequently verified in an individual database. Results. Of the 18 modules obtained, the cyan module was designated as the key module. The established ceRNA network was composed of seven lncRNAs, 45 mRNAs, and 21 microRNAs (miRNAs), and the FAM13A-AS1 was the lncRNA with the highest centrality. Functional assessments indicated that the genes in the cyan module primarily gathered in ribosome-related functional terms. Interestingly, the targeted mRNAs of the ceRNA network enriched in diverse categories. Moreover, highly expressed CYBRD1, GNG12, and SMAD1, which were identified as hub genes, may be associated with “valine leucine and isoleucine degradation,” “base excision repair,” and “fatty acid metabolism,” respectively, according to the results of single gene-based genomes and gene set enrichment analysis (GSEA). Conclusions. Combined with the WGCNA and ceRNA network, our findings provide novel insights into the pathogenesis of MS. The hub genes discovered herein might also serve as novel biomarkers that correlate with the development and management of MS.

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“…TUG1 expression negatively correlates with miR-9-5p, positively with NF-ĸB1/p50, and it was verified that TUG1 negatively regulates miR-9-5p; hence NF-ĸB1/p50 is affected as a direct target of miR-9-5p [ 60 ]. Gm15575 is a proinflammatory lncRNA regulating Th17 function through acting as competing endogenous RNA for miR-686 and positively regulating CCL7 in TH17 differentiation in EAE [ 61 ].…”

Section: Long Non-coding Rnasmentioning

confidence: 99%

“…It is inhibited by miR-let-7f-5p, miR-20b, and regulated indirectly by miR-301a through its action of PIAS3, which inhibits STAT3 [ [93] , [94] , [95] ]. Some lncRNAs act as competing endogenous RNAs for miRNAs such as Gm15575 and GAS5 for miR-686 and miR-137, respectively [ 61 , 65 ]. Along with its effect on miR-686, Gm15575 positively regulates CCL7 enhancing Th17 differentiation in EAE while miR-23b was found to suppress CCL7 inhibiting the migration of pathogenic T cells in EAE development [ 32 , 61 ].…”

Section: Cross-over Between Regulation Of Lncrnas and Mirnas In Msmentioning

confidence: 99%

“…Some lncRNAs act as competing endogenous RNAs for miRNAs such as Gm15575 and GAS5 for miR-686 and miR-137, respectively [ 61 , 65 ]. Along with its effect on miR-686, Gm15575 positively regulates CCL7 enhancing Th17 differentiation in EAE while miR-23b was found to suppress CCL7 inhibiting the migration of pathogenic T cells in EAE development [ 32 , 61 ]. An interesting correlation is the role of PVT1 lncRNA in regulating Th17 cell response in EAE by sponging miR-21-5p, upregulating SOCS5, and inactivating the JAKs/STAT3 pathway providing a potential therapeutic pathway [ 96 ].…”

Section: Cross-over Between Regulation Of Lncrnas and Mirnas In Msmentioning

confidence: 99%

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Scavenging the hidden impacts of non-coding RNAs in multiple sclerosis

Elkhodiry

Tayebi

2021

Non-coding RNA Research

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Multiple sclerosis (MS) is a chronic neuroinflammatory disease that causes severe neurological dysfunction leading to disabilities in patients. The prevalence of the disease has been increasing gradually worldwide, and the specific etiology behind the disease is not yet fully understood. Therapies aimed against treating MS patients have been growing lately, intending to delay the disease progression and increase the patients' quality of life. Various pathways play crucial roles in developing the disease, and several therapeutic approaches have been tackling those pathways. However, these strategies have shown several side effects and inconsistent efficacy. MicroRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs) have been shown to act as key players in various disease pathogenesis and development. Several proinflammatory and anti-inflammatory miRNAs have been reported to participate in the development of MS. Hence, the review assesses the role of miRNAs, lncRNAs, and circRNAs in regulating immune cell functions better to understand their impact on the molecular mechanics of MS.

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Gm15575 functions as a ceRNA to up-regulate CCL7 expression through sponging miR-686 in Th17 cells

Cited by 13 publications

References 38 publications

Long Non-Coding RNAs, Novel Offenders or Guardians in Multiple Sclerosis: A Scoping Review

Long Non-Coding RNAs, Novel Offenders or Guardians in Multiple Sclerosis: A Scoping Review

Identification of Novel Key Genes and Pathways in Multiple Sclerosis Based on Weighted Gene Coexpression Network Analysis and Long Noncoding RNA-Associated Competing Endogenous RNA Network

Scavenging the hidden impacts of non-coding RNAs in multiple sclerosis

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