Gnathic bone metastasis: a retrospective study of 10 cases

Antunes, Antônio Azoubel

doi:10.1016/s1808-8694(15)30603-0

Cited by 23 publications

(25 citation statements)

References 11 publications

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“…The female gender is more affected by pathology, agreeing with the findings in research and case reports, only 2 cases are reported in the masculine gender [3].…”

Section: Discussionsupporting

confidence: 89%

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Metastasis of Thyroid Adenocarcinoma in Mandible

Figueiredo¹,

Loureiro²

2017

IJDOS

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“…The female gender is more affected by pathology, agreeing with the findings in research and case reports, only 2 cases are reported in the masculine gender [3].…”

Section: Discussionsupporting

confidence: 89%

“…The diagnosis of primary and metastatic malignant gnathic bone neoplasms is primarily made on a clinical anamnesis, laboratorial, radiological and histopathological data. The diagnosis of those neoplasms can, however, offer difficulties with regard to their differential aspects [3].…”

Section: Open Access Http://scidocorg/ijdosphpmentioning

confidence: 99%

Metastasis of Thyroid Adenocarcinoma in Mandible

Figueiredo¹,

Loureiro²

2017

IJDOS

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“…Thyroid malignancy represents 2% of facial skeleton metastasis [20] and 4.2–6.1% of all jaw metastases [7, 15, 21] 41% of facial skeleton metastasis from thyroid cancer occurs in the mandible; 59% of these metastases are well-differentiated thyroid cancer. There have been 41 reported cases in the literature of thyroid malignancy with metastasis to the mandible of which 21 reported cases were FTC [4, 9–12, 22–47]. There have been 6 reported cases of metastasis to the maxilla; 2 were FTC [22, 48–52].…”

Section: Discussionmentioning

confidence: 99%

“…There have been 41 reported cases in the literature of thyroid malignancy with metastasis to the mandible of which 21 reported cases were FTC [4, 9–12, 22–47]. There have been 6 reported cases of metastasis to the maxilla; 2 were FTC [22, 48–52]. …”

Section: Discussionmentioning

confidence: 99%

Follicular thyroid carcinoma metastasis to the facial skeleton: a systematic review

et al. 2017

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BackgroundFollicular thyroid carcinoma (FTC) metastasis to the facial skeleton is exceedingly rare. A case of FTC metastasizing to the mandible is presented and a systematic review of the literature describing thyroid metastasis to the facial skeleton is performed.Case presentationA 73-year-old female presented with metastatic FTC to the mandible and underwent total thyroidectomy, segmental mandibulectomy, bone impacted fibular free flap reconstruction, and adjuvant radioactive iodine treatment. The PubMed database was searched for literature describing thyroid cancer with facial skeleton metastasis using the key words “thyroid,” “cancer,” “carcinoma,” “metastasis,” and “malignancy” with “oral cavity,” “maxilla,” “mandible,” “sinus,” “paranasal,” and “orbit.” Reports that only involved the soft tissues were excluded. Systematic review revealed 59 cases of well-differentiated thyroid cancer with facial skeleton metastasis: 35 mandibular metastases (21 = FTC), 6 maxilla metastases (2 = FTC), 9 orbital metastases (4 = FTC), and 11 paranasal sinus metastases (7 = FTC). Treatment included surgery, RAI, external beam radiotherapy (XRT), or a combination of these modalities. The one, two, and five-year survival rates were 100%, 79%, and 16%, respectively.ConclusionFacial skeleton metastasis of FTC is a rare clinical challenge. Optimal treatment appears to include total thyroidectomy and resection of involved structures with or without adjuvant treatment.

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“…Involvement of the jaw can be considered more common than involvement of oral soft tissue (Hirshberg et al, 2008; Summerlin, 1994). Metastases to the oral cavity can arise from any part of the body, but tumors of epithelial origin (carcinoma) occur more frequently (D'Silva et al, 2006; Hirshberg et al, 2008; Bodner et al, 2006; Antunes and Antunes, 2008). The common primary sites of metastatic oral cavity tumors are the breast in females and lung in males (Hirshberg et al, 2008; Allon et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Metastatic solid tumors to the jaw and oral soft tissue: A retrospective clinical analysis of 44 patients from a single institution

Owosho

Kadempour

et al. 2016

Journal of Cranio-Maxillofacial Surgery

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Summary Purpose Metastatic solid tumors to the oral cavity are rare, frequently indicative of an end-stage disease process, and associated with poor survival rates. We performed a 20-year retrospective clinical analysis of our institution’s cases of solid metastases to the oral cavity, and investigated these patients’ clinical outcomes. Material and Methods A retrospective study of patients with metastatic solid tumors to the oral cavity over a 20-year period (October 1996 to September 2015) was conducted at Memorial Sloan Kettering Cancer Center. Patients were selected if they had a histopathologically confirmed diagnosis. Demographic, pathologic, and clinical information were reviewed to identify patient outcomes. Results A total of 44 patients with metastatic non-melanocytic non-hematopoietic tumor to the oral cavity were identified: 24 males and 20 females (39 adults and 5 children) with a mean age of 54.3 years. In all, 24 cases involved the jaw and 20 cases involved the oral soft tissue. Eight patients (18.2%) had oral cavity metastases as the first indication of an occult malignancy. In adult patients, the common primary sites were the lungs (n = 9, 20%), kidney (n = 7, 16%), breast (n = 5, 11%), and colon (n = 4, 9%); and in pediatric patients the adrenal gland (3/5) was the most common site. Of the adult patients, 33 (84.6%) died of disease. From the time of metastasis diagnosis, patients with jaw metastases had a median and mean survival of 12 months and 27.7 months, respectively. In comparison, patients with oral soft tissue metastases had a median survival time of 5 months, and mean of 8 months. One pediatric patient (20%) died of disease 8 months after metastasis diagnosis. Conclusion Metastatic solid tumors to the oral cavity can be the first sign of a malignancy. Pediatric patients with oral cavity metastases have a better prognosis compared to adult patients. In this series, adults with oral soft tissue involvement had shorter survival times compared to patients with jaw involvement.

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Gnathic bone metastasis: a retrospective study of 10 cases

Cited by 23 publications

References 11 publications

Metastasis of Thyroid Adenocarcinoma in Mandible

Metastasis of Thyroid Adenocarcinoma in Mandible

Follicular thyroid carcinoma metastasis to the facial skeleton: a systematic review

Metastatic solid tumors to the jaw and oral soft tissue: A retrospective clinical analysis of 44 patients from a single institution

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