Goat Milk Fat Naturally Enriched with Conjugated Linoleic Acid Increased Lipoproteins and Reduced Triacylglycerol in Rats

Rodrigues, Raphaela Araújo Veloso; Soares, Juliana Késsia Barbosa; Garcia, Hugo; Nascimento, C H; Medeiros, Maria das Graças Freire de; Bomfim, M. A. D.; Queiroga, Rita C.R.E.

doi:10.3390/molecules19033820

Cited by 11 publications

(7 citation statements)

References 50 publications

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“…The obtained results did not reveal significant effects on body weight. Similar studies, based on rats, were performed by Rodrigues et al [109], who examined the influence of goat milk fat naturally enriched with CLA. Similarly to the previous study, body weight of the examined rats in comparison to control group was not much lower.…”

Section: Conjugated Fatty Acidsmentioning

confidence: 64%

Secondary Metabolites, Dietary Fiber and Conjugated Fatty Acids as Functional Food Ingredients against Overweight and Obesity

Kasprzak

Wojtunik-Kulesza

Oniszczuk

et al. 2018

Natural Product Communications

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Obesity is a common serious health problem leading to many serious health disorders. This phenomenon is defined as the over-storage of lipids in adipose tissue that occurs when there is an imbalance between the energy intake and energy used. During obesity, many metabolic alterations occur that can damage several organs, such as vascular or skeletal muscle resulting in the dysfunction of these tissues. In this review, we will discuss molecular genetics and causes of obesity, some of the disorders related to human obesity as well as anti-obesity tool. An interesting solution to the obesity problem is natural substances, revealing anti-obesity activity, as well as functional food enriched with aforementioned substances. Functional foods are products exhibiting a potentially positive effect on health beyond basic nutrition. They contain well-known biologically active natural compounds, which promote optimal health and reduce the risk of many diseases, including obesity.

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Section: Conjugated Fatty Acidsmentioning

confidence: 64%

Secondary Metabolites, Dietary Fiber and Conjugated Fatty Acids as Functional Food Ingredients against Overweight and Obesity

Kasprzak

Wojtunik-Kulesza

Oniszczuk

et al. 2018

Natural Product Communications

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“…The CLA improved insulin resistance by increasing mRNA expression of PPAR-γ, and its target genes such as fatty acid binding proteins, fatty acid transporter proteins and adiponectin in the adipose tissues of the obese rats. In another study, Rodrigues et al (2014) used fat from goat milk naturally enriched with CLA to investigate the effects of CLA on serum lipids and glucose, body weight, and intestinal and liver histopathological parameters of male rats. They showed that CLA caused an increase in the body weight of the rats from the second to the fifth wk of the experiment, indicating its growth promoting activity in young rats.…”

Section: Effects Of Cla On Cancermentioning

confidence: 99%

Conjugated linoleic acid: A potent fatty acid linked to animal and human health

Shokryzadan

Rajion

Goh

et al. 2015

Critical Reviews in Food Science and Nutrition

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Conjugated linoleic acid (CLA) is a mixture of isomers of linoleic acid (C18:2 n-6), which is mostly found in the ruminant meat and dairy products. The CLA is known to have many potential health benefits, and considered a potent powerful fatty acid, which is linked to animal and human health. The present work aims to discuss the source and production, mechanism of action, and effects of CLA on humans, poultry, and ruminants by reviewing the recent studies carried out on CLA. Despite most of the recent studies indicating beneficial effects of CLA on improving body weight control parameters, its effects on reducing risk factors of cardiovascular diseases (CVD), inflammation, blood glucose, and insulin are still controversial, and need to be further studied in different hosts.

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“…A westernized diet increases the bacteria counts belonging to phylum Firmicutes which are associated with negative impacts on human health [40]. However, our results show that GMW supplementation increases the number of total lactobacilli in both dams and offspring.…”

Section: Journal Of Food and Nutrition Researchmentioning

confidence: 49%

Goat Milk Whey Improves Nutritional Status, Fecal Microbial Composition and Intestinal Morphology in Female Rats Fed a Westernized Diet and Their Offspring

Paulino¹,

Aquino²,

Souza³

et al. 2019

JFNR

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This study evaluated whether supplementation with goat milk whey (GMW) affects the nutritional status, intestinal histology and intestinal microbial composition of female rats fed a westernized diet from gestation to lactation, as well as whether changes can be replicated in the offspring at the end of weaning and at 45 days of life. Pregnant female rats were randomized into four groups: control group (CSAL), control group supplemented with GMW (CGOAT), westernized group (WSAL) or westernized group supplemented with GMW (WGOAT). After weaning, half of offspring were euthanized and the rest of the offspring were maintained under the same treatment applied to dams, up to 45 days of life. Body weight, food intake, intestinal histology and counting of fecal microbial groups were determined in both female rats and offspring. The offspring supplemented with GMW showed decreased body weight at weaning. After weaning, groups supplemented with GMW showed reduced body weight and visceral fat, increased fecal lactobacilli counts in rats and offspring and attenuation of damages induced by the westernized diet on intestinal epithelial cells. GMW supplementation caused a positive effect on fecal microbial composition, intestinal morphology and induced reduction in weight gain and visceral fat in female rats and offspring fed westernized diet. These effects appear to be dependent on the animal's age and period time of GMW supplementation.

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Goat Milk Fat Naturally Enriched with Conjugated Linoleic Acid Increased Lipoproteins and Reduced Triacylglycerol in Rats

Cited by 11 publications

References 50 publications

Secondary Metabolites, Dietary Fiber and Conjugated Fatty Acids as Functional Food Ingredients against Overweight and Obesity

Secondary Metabolites, Dietary Fiber and Conjugated Fatty Acids as Functional Food Ingredients against Overweight and Obesity

Conjugated linoleic acid: A potent fatty acid linked to animal and human health

Goat Milk Whey Improves Nutritional Status, Fecal Microbial Composition and Intestinal Morphology in Female Rats Fed a Westernized Diet and Their Offspring

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