Goiter Frequency Is More Strongly Associated with Gastric Adenocarcinoma than Urine Iodine Level

Tabaeizadeh, Mohammad; Haghpanah, Vahid; Keshtkar, Abbasali; Semnani, Shahryar; Roshandel, Gholamreza; Adabi, Khadijeh; Heshmat, Ramin; Rohani, Davood; Kia, A Heshmati; Hatami, Ehsan; Jahangirrad, Ataollah; Nabizadeh, Ramin; Larijani, Bagher

doi:10.5230/jgc.2013.13.2.106

Cited by 9 publications

(5 citation statements)

References 15 publications

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“…In the Chinese study, goiter was associated with a marginal increase in the risk of gastric non-cardia adenocarcinoma [17]. In a small sample of Iranian patients with gastric adenocarcinoma, a higher prevalence of goiter and lower circulating levels of T3, although not T4, compared with controls, were reported [33]. In the Danish study of Kirkegård et al the overall risk of GC was increased compared with the general population (standardized incidence ratio 1.49; 95%CI 1.26-1.75) [25].…”

Section: Discussionmentioning

confidence: 90%

Male Predominance of Gastric Cancer among Patients with Hypothyroidism from a Defined Geographic Area

Dore

Manca

Pensamiento

et al. 2020

JCM

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In the past, hypothyroidism has been associated with an increased susceptibility to gastric cancer (GC). Although several epidemiological studies have corroborated this association, a precise mechanistic explanation remains elusive. In this study, this hypothesis was tested by using a large database of subjects who underwent upper endoscopy for various reasons. This was a retrospective, case-control, single-center study. Subjects with GC (cases) were compared with subjects without (controls), according to hypothyroidism status. Overall, the prevalence of GC was 0.73% in the total cohort and was significantly higher in males compared to females (1.4% versus 0.4%, p < 0.0001). Multivariate logistic regression analysis confirmed an increased risk in males with hypothyroidism (OR 5.10; p < 0.0001) after adjusting for potential confounders, especially H. pylori infection. Interestingly, only hypothyroidism and not treatment with levothyroxine was a significant predictor of GC, ruling out a possible direct carcinogenic effect of the replacement therapy. The present study suggests a male-restricted association of gastric carcinogenesis with a hypothyroid state. If the results of this study are confirmed by longitudinal studies, an attractive perspective could open up for the better management of males with concomitant hypothyroidism and a higher risk of GC.

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Section: Discussionmentioning

confidence: 90%

Male Predominance of Gastric Cancer among Patients with Hypothyroidism from a Defined Geographic Area

Dore

Manca

Pensamiento

et al. 2020

JCM

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“…These effects may explain the regulatory role of iodine in the proliferation of mucosal cells and its protective role against gastric carcinogenesis ( 11 , 16 ). This hypothesis has been confirmed by the reported link among iodine deficiency, goiter, and increased risk of developing gastric cancer ( 18 ).…”

Section: Thyroid and Stomach: Embryologic Derivation And Role Of Na mentioning

confidence: 59%

Hashimoto’s Thyroiditis and Autoimmune Gastritis

Cellini¹,

Santaguida²,

Virili³

et al. 2017

Front. Endocrinol.

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The term “thyrogastric syndrome” defines the association between autoimmune thyroid disease and chronic autoimmune gastritis (CAG), and it was first described in the early 1960s. More recently, this association has been included in polyglandular autoimmune syndrome type IIIb, in which autoimmune thyroiditis represents the pivotal disorder. Hashimoto’s thyroiditis (HT) is the most frequent autoimmune disease, and it has been reported to be associated with gastric disorders in 10–40% of patients while about 40% of patients with autoimmune gastritis also present HT. Some intriguing similarities have been described about the pathogenic mechanism of these two disorders, involving a complex interaction among genetic, embryological, immunologic, and environmental factors. CAG is characterized by a partial or total disappearance of parietal cells implying the impairment of both hydrochloric acid and intrinsic factor production. The clinical outcome of this gastric damage is the occurrence of a hypochlorhydric-dependent iron-deficient anemia, followed by pernicious anemia concomitant with the progression to a severe gastric atrophy. Malabsorption of levothyroxine may occur as well. We have briefly summarized in this minireview the most recent achievements on this peculiar association of diseases that, in the last years, have been increasingly diagnosed.

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“…It is hypothesized that iodine deficiency may be associated with a heightened risk of gastric, breast and thyroid cancer [ 8 ]. Studies indicate that iodine treatment leads to induction of programmed cell death through mitochondrial pathway or generation of iodolipids and also inhibition of cell proliferation [ 9 , 10 ]. Most importantly, iodine has been shown to impact polyphenol content in lettuce which may constitute an indirect mechanism of iodine-mediated anticancer effects [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Molecular Effects of Iodine-Biofortified Lettuce in Human Gastrointestinal Cancer Cells

et al. 2022

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Considering the growing number of cancer cases around the world, natural products from the diet that exhibit potential antitumor properties are of interest. Our previous research demonstrated that fortification with iodine compounds is an effective way to improve the antioxidant potential of lettuce. The purpose of the present study was to evaluate the effect of iodine-biofortified lettuce on antitumor properties in human gastrointestinal cancer cell lines, gastric AGS and colon HT-29. Our results showed that extracts from iodine-biofortified lettuce reduce the viability and proliferation of gastric and colon cancer cells. The extracts mediated cell cycle arrest which was accompanied by inactivation of anti-apoptotic Bcl-2 and activation of caspases, as assessed by flow cytometry. However, extracts from lettuce fortified with organic forms of iodine acted more effectively than extracts from control and KIO3-enriched plants. Using quantitative PCR, we detected the increase in pro-apoptotic genes BAD, BAX and BID in AGS cells whereas up-regulation of cell cycle progression inhibitor CDKN2A and downregulation of pro-proliferative MDM2 in HT-29 cells. Interestingly, lettuce extracts led to down-regulation of pro-survival AKT1 and protooncogenic MDM2, which was consistent for extracts of lettuce fortified with organic form of iodine, 5-ISA, in both cell lines. MDM2 downregulation in HT-29 colon cancer cells was associated with RB1 upregulation upon 5-ISA-fortified lettuce extracts, which provides a link to the epigenetic regulation of tumor suppressor genes by RB/MDM2 pathway. Indeed, SEMA3A tumor suppressor gene was hypomethylated and upregulated in HT-29 cells treated with 5-ISA-fortified lettuce. Control lettuce exerted similar effects on RB/MDM2 pathway and SEMA3A epigenetic activation in HT-29 cells. Our findings suggest that lettuce as well as lettuce fortified with organic form of iodine, 5-ISA, may exert epigenetic anti-cancer effects that can be cancer type-specific.

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Goiter Frequency Is More Strongly Associated with Gastric Adenocarcinoma than Urine Iodine Level

Cited by 9 publications

References 15 publications

Male Predominance of Gastric Cancer among Patients with Hypothyroidism from a Defined Geographic Area

Male Predominance of Gastric Cancer among Patients with Hypothyroidism from a Defined Geographic Area

Hashimoto’s Thyroiditis and Autoimmune Gastritis

Molecular Effects of Iodine-Biofortified Lettuce in Human Gastrointestinal Cancer Cells

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