Gold‐Based Therapeutic Agents: A New Perspective

Auranofin and related heterometallic gold(I)–thiolates as potent inhibitors of methicillin-resistant Staphylococcus aureus bacterial strains

“…During the past two decades there has been a renewed interest in the study of the biological activities and potential medicinal applications of gold compounds [1]. In particular, gold(I) compounds have been thoroughly explored as cytotoxic agents [2].…”

Cytotoxic hydrophilic iminophosphorane coordination compounds of d8 metals. Studies of their interactions with DNA and HSA

“…A growing number of so-called “cisplatin rule-breaker” compounds have been reported [3–5] along with some Pt(IV) pro-drugs that can be photoactivated by visible light [7]. These findings have paved the way for studying other metal-based chemotherapeutic compounds [3] including relevant examples of gold [9], palladium [10], titanium [11], ruthenium [12], osmium [13] and iron complexes [14]. …”

Solution study under physiological conditions and cytotoxic activity of the gold(III) complexes with L-histidine-containing peptides

“…However, the high reduction potential and fast rate of hydrolysis of Au(III) complexes under physiologically relevant conditions hindered their possible application in medicine. 3 Despite that, stability of the Au(III) ion has been achieved by an appropriate choice of the ligands, in most cases containing nitrogen donor atoms. [4][5][6][7][8][9][10][11][12][13][14][15][16] Thus, different polydentate ligands, such as polyamines, bipyridine, terpyridine, phenanthroline, macrocyclic ligands (cyclam), porphyrins and dithiocarbamates, have been used and a number of mononuclear and dinuclear gold(III) complexes have been synthesized that show remarkable stability under physiologically relevant conditions.…”