GOLD: human exposure and update on toxic risks

Lansdown, A. B. G.

doi:10.1080/10408444.2018.1513991

Cited by 38 publications

(24 citation statements)

References 189 publications

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“…Importantly, clinicians need to be aware of what medications are associated with DILD. The main nonbiological DMARDs include gold (94,95), penicillamine (96), sulfasalazine (97), tacrolimus (98,99), methotrexate (MTX) (93,(100)(101)(102), and leflunomide (103)(104)(105), and the biological agents mainly include anti-TNF, anti-CD20, and cytokine monoclonal antibodies (106,107). Although MTX-induced ILD is well-established by many studies, there is some emerging conflicting evidence suggesting no association between MTX and RA-ILD (108).…”

Section: Environmental Factorsmentioning

confidence: 99%

Interstitial Lung Disease in Connective Tissue Disease: A Common Lesion With Heterogeneous Mechanisms and Treatment Considerations

et al. 2021

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Connective tissue disease (CTD) related interstitial lung disease (CTD-ILD) is one of the leading causes of morbidity and mortality of CTD. Clinically, CTD-ILD is highly heterogenous and involves rheumatic immunity and multiple manifestations of respiratory complications affecting the airways, vessels, lung parenchyma, pleura, and respiratory muscles. The major pathological features of CTD are chronic inflammation of blood vessels and connective tissues, which can affect any organ leading to multi-system damage. The human lung is particularly vulnerable to such damage because anatomically it is abundant with collagen and blood vessels. The complex etiology of CTD-ILD includes genetic risks, epigenetic changes, and dysregulated immunity, which interact leading to disease under various ill-defined environmental triggers. CTD-ILD exhibits a broad spectra of clinical manifestations: from asymptomatic to severe dyspnea; from single-organ respiratory system involvement to multi-organ involvement. The disease course is also featured by remissions and relapses. It can range from stability or slow progression over several years to rapid deterioration. It can also present clinically as highly progressive from the initial onset of disease. Currently, the diagnosis of CTD-ILD is primarily based on distinct pathology subtype(s), imaging, as well as related CTD and autoantibodies profiles. Meticulous comprehensive clinical and laboratory assessment to improve the diagnostic process and management strategies are much needed. In this review, we focus on examining the pathogenesis of CTD-ILD with respect to genetics, environmental factors, and immunological factors. We also discuss the current state of knowledge and elaborate on the clinical characteristics of CTD-ILD, distinct pathohistological subtypes, imaging features, and related autoantibodies. Furthermore, we comment on the identification of high-risk patients and address how to stratify patients for precision medicine management approaches.

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Section: Environmental Factorsmentioning

confidence: 99%

Interstitial Lung Disease in Connective Tissue Disease: A Common Lesion With Heterogeneous Mechanisms and Treatment Considerations

et al. 2021

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“…31 For example, gold miners have to face different lung diseases due to exposure to gold dust from their occupational circumstances. [32][33][34] Recent experimental studies suggested that the inhaled NPs (engineered or environmental) may be responsible for lung-related diseases and AuNPs were detected longer times after exposure, when compared to other NPs. 8,35 It has also been observed that the detection levels were higher for 5 nm (diameter) sized AuNPs compared to 30 nm (diameter) AuNPs, and that AuNPs with the size <10 nm (diameter) showed higher translocation ability than larger AuNPs.…”

Section: Introductionmentioning

confidence: 99%

The role of SP-B_1–25 peptides in lung surfactant monolayers exposed to gold nanoparticles

Hossain

Gandhi

Hughes

et al. 2020

Phys. Chem. Chem. Phys.

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“…In part, this may be a consequence of limited systemic gold absorption from the gastrointestinal tract as metallic gold does not ionise. However, systemic gold absorption from soluble gold compounds, such as cyanide, bromide, iodide and thiosulfate, is thought to be higher 11. It has been suggested that KAuCN 2 may dissociate after ingestion to form aurocyanide (Au(CN) 2 -), a known metabolite of gold compounds used for immunotherapy.…”

Section: Discussionmentioning

confidence: 99%

Fatality from potassium gold cyanide poisoning

Harmon¹,

Lebin

Murphy

et al. 2019

BMJ Case Rep

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While potassium cyanide poisoning has been well described, the toxicity of potassium gold cyanide is less well understood. This case describes an 84-year-old man who presented after an intentional ingestion of 0.5–1 teaspoons of potassium gold cyanide. Despite antidotal therapy, the patient rapidly developed severe lactic acidosis, multiorgan dysfunction and ultimately expired. While the patient’s clinical findings were consistent with acute cyanide poisoning, a serum cyanide level was below the toxic threshold. Previous reports have suggested that gold toxicity may also contribute to the effects of potassium gold cyanide, and may have played a role in the patient’s rapid decline. In addition to treatment of cyanide toxicity, management of acute gold toxicity should also be considered in potassium gold cyanide ingestion.

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GOLD: human exposure and update on toxic risks

Cited by 38 publications

References 189 publications

Interstitial Lung Disease in Connective Tissue Disease: A Common Lesion With Heterogeneous Mechanisms and Treatment Considerations

Interstitial Lung Disease in Connective Tissue Disease: A Common Lesion With Heterogeneous Mechanisms and Treatment Considerations

The role of SP-B_1–25 peptides in lung surfactant monolayers exposed to gold nanoparticles

Fatality from potassium gold cyanide poisoning

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GOLD: human exposure and update on toxic risks

Cited by 38 publications

References 189 publications

Interstitial Lung Disease in Connective Tissue Disease: A Common Lesion With Heterogeneous Mechanisms and Treatment Considerations

Interstitial Lung Disease in Connective Tissue Disease: A Common Lesion With Heterogeneous Mechanisms and Treatment Considerations

The role of SP-B1–25 peptides in lung surfactant monolayers exposed to gold nanoparticles

Fatality from potassium gold cyanide poisoning

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The role of SP-B_1–25 peptides in lung surfactant monolayers exposed to gold nanoparticles