Gold nanocluster-based fluorescence sensing probes for detection of dipicolinic acid

Baig, Mirza Muhammad Fahad; Chen, Yu-Chie

doi:10.1039/c9an00240e

Cited by 19 publications

(4 citation statements)

References 37 publications

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“…There is a broad range of potential NC-templating molecules ( Fig. 1 ), including small molecules containing thiols, 13 such as glutathione (GSH) 14 and 2-mercaptosuccinic acid (MSA), 15 that work as both reducing and stabilizing agents and are characterized by the strong interaction of the sulfur atoms with gold. Polymers, like polyethyleneimine (PEI), are also good templating agents but they should contain hydroxyl or amino groups.…”

Section: Introductionmentioning

confidence: 99%

Biomarker sensing platforms based on fluorescent metal nanoclusters

et al. 2021

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Section: Introductionmentioning

confidence: 99%

Biomarker sensing platforms based on fluorescent metal nanoclusters

et al. 2021

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“…In terms of surface ligands, AuNCs are generally classified into thiolated AuNCs, dendrimer- or polymer-protected AuNCs, protein-templated or protein-protected AuNCs, DNA-templated AuNCs, and small-molecule-protected AuNCs [ 13 ]. Among various AuNCs, glutathione (GSH)-stabilized AuNCs (GSH-AuNCs) have been demonstrated to have many interesting properties and have been used in the detection of heavy metal ions such as Cr 3+ [ 14 ], Cu 2+ [ 15 ], Hg 2+ [ 16 , 17 , 18 ], and Ag + [ 19 , 20 ]; thiol [ 21 , 22 ]; and alkaline peptide and alkaline phosphatase [ 23 , 24 ]. GSH-AuNCs have also been applied to detect the electron deficiency of dopamine [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

A Fluorescent Detection for Paraquat Based on β-CDs-Enhanced Fluorescent Gold Nanoclusters

Ren

Mao

et al. 2021

Foods

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In this report, a fluorescent sensing method for paraquat based on gold nanoclusters (AuNCs) is proposed. It was found that paraquat could quench both glutathione-capped AuNCs (GSH-AuNCs) and β-cyclodextrin-modified GSH-AuNCs (GSH/β-CDs-AuNCs). The modification of β-CDs on the surface of GSH-AuNCs obviously enhanced the fluorescence intensity of GSH-AuNCs and improved the sensitivity of paraquat sensing more than 4-fold. This sensibilization was ascribed to the obvious fluorescence intensity enhancement of GSH-AuNCs by β-CDs and the “host–guest” interaction between paraquat and β-CDs. The fluorescence quenching was mainly due to the photoinduced energy transfer (PET) between GSH/β-CDs-AuNCs and paraquat. With the optimized β-CDs modification of the GSH-AuNC surfaces and under buffer conditions, the fluorescent detection for paraquat demonstrated a linear response in the range of 5.0–350 ng/mL with a detection limit of 1.2 ng/mL. The fluorescent method also showed high selectivity toward common pesticides. The interference from metal ions could be easily masked by ethylene diamine tetraacetic acid (EDTA). This method was applied to the measurement of paraquat-spiked water samples and good recoveries (93.6–103.8%) were obtained. The above results indicate that host molecule modification of fluorescent metal NC surfaces has high potential in the development of robust fluorescent sensors.

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“…The carcinoembryonic antigen (CEA), as one of the most common tumor markers, usually circulates at high concentrations in the patients infected with various cancers including malignant and epithelial tumors. , Henceforth, its effective monitoring in body fluids is of considerable importance for the timely alerting and therapy of cancer . In this regard, a number of techniques such as the enzyme-linked immunosorbent assay, fluorescence-based method, and surface-enhanced Raman scattering (SERS)-based immunoassay , have been sequentially developed to detect CEA in blood. Among them, the SERS-based immunoassay is superior for its unique fingerprint spectrum, narrow spectral bandwidth, fluorescence quenching, and single-molecule sensitivity.…”

Section: Introductionmentioning

confidence: 99%

Immunoassay of Tumor Markers Based on Graphene Surface-Enhanced Raman Spectroscopy

Chen

Liu

Jiang

et al. 2020

ACS Appl. Bio Mater.

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With a unique chemical enhancement capability, graphene oxide is exceptionally suitable to serve as an alternative surface-enhanced Raman scattering (SERS) substrate, which is usually defined as GERS. However, such a GERS matrix with both promising uniformity and molecule enrichment ability has not been applied in the quantitative detection of tumor markers. Herein, an ultrasensitive and specific immunoassay of carcinoembryonic antigens mediated by the GERS matrix was demonstrated. With the assistance of Au NRs as immunoprobes, a reliable limit of detection as low as 3.01 pg/mL was finally achieved because of the collective effect of chemical and electromagnetic enhancements. Meanwhile, a calibration curve with a high R 2 value of 0.996 was obtained in the range from 1 μg/mL to 10 pg/mL. These results exhibit that the GERS matrix has a great promise for participating in immunoassay, which may pave a potential avenue for the real utilization of the SERS technique in clinical biomedicine.

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Gold nanocluster-based fluorescence sensing probes for detection of dipicolinic acid

Abstract: A switched-on fluorescence sensing probe for the detection of dipicolinic acid (DPA) is demonstrated in this study.

Cited by 19 publications

References 37 publications

Biomarker sensing platforms based on fluorescent metal nanoclusters

Biomarker sensing platforms based on fluorescent metal nanoclusters

A Fluorescent Detection for Paraquat Based on β-CDs-Enhanced Fluorescent Gold Nanoclusters

Immunoassay of Tumor Markers Based on Graphene Surface-Enhanced Raman Spectroscopy

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