Gold nanoclusters for controlled insulin release and glucose regulation in diabetes

Zhang, Yujie; Wu, Mingxin; Dai, Wubin; Li, Yinping; Wang, Xin; Tan, Di; Yang, Zhilu; Liu, Sheng; Xue, Longjian; Lei, Yifeng

doi:10.1039/c9nr00668k

Cited by 34 publications

(35 citation statements)

References 43 publications

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“…In addition to enzymes, some small molecules which have specific affinity to glucose are commonly used for detection of glucose. Among them, PBA and its derivatives are commonly used as the recognition agents for glucose [ [35] , [36] , [37] , [38] ], taking the advantage that PBA and its derivatives are able to reversibly bind with the adjacent diols of glucose [ 39 , 40 ]. This property of PBA was widely incorporated into smart hydrogels for biosensing of glucose [ 35 , 36 , 41 ].…”

Section: Smart Materials For Sensing Of Glucosementioning

confidence: 99%

Responsive principles and applications of smart materials in biosensing

Guo

Liu

Dai

et al. 2020

Smart Materials in Medicine

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Biosensing is a rising analytical field for detection of biological indicators using transducing systems. Smart materials can response to external stimuli, and translate the stimuli from biological domains into signals that are readable and quantifiable. Smart materials, such as nanomaterials, photonic crystals and hydrogels have been widely used for biosensing purpose. In this review, we illustrate the incorporation of smart materials in biosensing systems, including the design of responsive materials, their responsive mechanism of biosensing, and their applications in detection of four types of common biomolecules (including glucose, nucleic acids, proteins, and enzymes). In the end, we also illustrate the current challenges and prospective of using smart materials in biosensing research fields.

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Section: Smart Materials For Sensing Of Glucosementioning

confidence: 99%

Responsive principles and applications of smart materials in biosensing

Guo

Liu

Dai

et al. 2020

Smart Materials in Medicine

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“…[1][2][3][4][5][6] Gold nanoparticles (Au NPs) have been widely used in biomedical fields due to their diverse morphology, well biocompatibility and remarkable near-infrared response characteristics. [7][8][9][10][11][12] There are many classical methods for the synthesis of Au NPs, [13][14][15][16][17][18][19] for instance, classical gold nanospheres (Au NSs) can be obtained by directly adding a reducing agent into the chloroauric acid ( Figure 1A, Protocol I). 20 Furthermore, adding reductants with some protectants to chloroauric acid may lead to other shapes, such as gold nanorods (Au NRs) ( Figure 1A, Protocol II).…”

Section: Introductionmentioning

confidence: 99%

<p>Banana Peel-Derived Dendrite-Shaped Au Nanomaterials with Dual Inhibition Toward Tumor Growth and Migration</p>

Liu

Song

Cao

et al. 2020

IJN

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In order to prepare functional Au nanoparticles with low toxicity and high antitumor properties, we have used fruit waste (banana peel) to synthesize a new dendriteshaped gold nanoparticle and used it for the treatment of tumors. Methods: Dendrite-shaped gold nanoparticle (Au-dendrite) was synthesized through a facile hydrothermal process. The banana peel was used as both the reducing agent and the protective agent for reducing chloroauric acid to obtain Au-dendrite. The safety assessment of the Au-dendrite was conducted by H&E staining of the mouse's eyelid skin and CCK-8 assay. The antitumor effects were evaluated through in vitro tumor cytotoxicity experiments and in vivo treatment of animal tumors. Results: In this work, a new type of gold nanomaterial (Au-dendrite) was synthesized by using a common agricultural waste (banana peel) through a facile hydrothermal process without any extra chemical reducing agent or protective agent. Subsequent experiments showed that, compared with some classical Au nanomaterials, the as-synthesized gold nanocomposites have superior biocompatibility and impressive characteristics of dual inhibition toward tumor growth and migration. Conclusion: We successfully synthesized a dendrite-shaped gold nanocomposite which was derived from a common agricultural waste (banana peel). A facile and environmentally friendly synthetic process was proposed accordingly without regular chemical additives. The as-prepared Au-dendrite nanocomposites not only had better biocompatibility than some classical gold nanoparticles but also exhibited unique advantages in tumor inhibition.

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“…[8][9][10][11][12][13][14][15][16][17][18] The structure of many carriers obtained consists of phenylboronic acid, [19][20][21][22][23][24][25][26][27] and their action is based on the interaction of boronates with glucose. [28][29][30][31][32][33] Boronic acid and their esters are sensitive to many carbohydrates containing cis-1,2-and cis-1,3-diol fragments. However, only glucose exists in the blood, other carbohydrates undergo chemical transformations to glucose and triglycerides in the liver.…”

Section: Introductionmentioning

confidence: 99%

“…One of the most promising approaches is the creation of nanocarriers that release insulin at high glucose concentrations . The structure of many carriers obtained consists of phenylboronic acid, and their action is based on the interaction of boronates with glucose . Boronic acid and their esters are sensitive to many carbohydrates containing cis‐1,2‐ and cis‐1,3‐diol fragments.…”

Section: Introductionmentioning

confidence: 99%

A Glucose‐Responsive Polymer Nanocarrier Based on Sulfonated Resorcinarene for Controlled Insulin Delivery

et al. 2019

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A nanocarrier (p(6SRA‐5B)) for glucose‐controlled insulin delivery consists of sulfonated resorcinarenes (SRA) that are assembled into a spherical shell and are attached to each other with phenylboronate linkers. p(6SRA‐5B) is stable in water and blood plasma at normal glucose concentrations. At high glucose levels (>5 mM), p(6SRA‐5B) dissociates into SRA and phenylboronates through competitive interaction with excess glucose. Insulin was successfully encapsulated into the cavity of p(6SRA‐5B) and its release was investigated in water and blood plasma by NMR, UV, CD, and fluorescence spectroscopy. The results show that the dissociation of the nanocarrier and the insulin release occurs with an increase in glucose concentration. At 5 mM glucose, the nanocarrier is stable, and the insulin release does not exceed 10 %. Increasing the glucose concentration to 7.5–10 mM results in a 40–100 % insulin release. p(6SRA‐5B) is thus a promising insulin nanocarrier for the treatment of type 1 diabetes.

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Gold nanoclusters for controlled insulin release and glucose regulation in diabetes

Abstract: Gold nanoclusters (GNCs) release insulin to reduce high blood glucose in diabetes.

Cited by 34 publications

References 43 publications

Responsive principles and applications of smart materials in biosensing

Responsive principles and applications of smart materials in biosensing

<p>Banana Peel-Derived Dendrite-Shaped Au Nanomaterials with Dual Inhibition Toward Tumor Growth and Migration</p>

A Glucose‐Responsive Polymer Nanocarrier Based on Sulfonated Resorcinarene for Controlled Insulin Delivery

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