Gold nanoparticle–based lateral-flow immunochromatographic biosensing assays for the diagnosis of infections

Guliy, Olga I.; Dykman, Lev A.

doi:10.1016/j.biosx.2024.100457

Cited by 1 publication

(2 citation statements)

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“…Gold nanoparticles have good antimicrobial and antibacterial properties that resist human infectious agents [15]. The antimicrobial properties of gold nanoparticles include a wide range of bacteria.…”

Section: Introductionmentioning

confidence: 99%

“…The antimicrobial properties of gold nanoparticles include a wide range of bacteria. Gold nanoparticles are synthesized by extracellular and intracellular methods, and the results of experiments conducted so far show that extracellular nanoparticles have better antibacterial effect on a scale with Nanoparticles produced are in a cell manner and their ability to inhibit the growth of pathogenic bacteria is much greater [12,15]. Today, with the advancement of technology, it is possible to produce nanoparticles from gold with different biological methods that have good antimicrobial properties and show good resistance to Gram-positive and negative bacteria [16].…”

Section: Introductionmentioning

confidence: 99%

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Halpeh Extract-Derived Gold Nanoparticles: A Dual Force Against Microbes and for Phytochemical Enhancement

Dahaz,

Asadi,

Lashgari

2024

Preprint

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The increasing resistance of pathogenic microorganisms to conventional antibiotics has led to a growing interest in alternative antimicrobial agents. In this study, the antimicrobial activity (antibacterial and antifungal) of aqueous and methanolic extracts of Halpeh plant and gold nanoparticles synthesized using the extract of this plant was investigated. Additionally, the effect of different concentrations of synthesized gold nanoparticles on the phytochemical properties (antioxidant and reducing ability) of Halpeh plant extract was examined. The results of UV-Vis (Ultraviolet-Visible Spectroscopy), XRD (X-Ray Diffraction Analysis), TEM (Transmission Electron Microscopy), SEM (Scanning Electron Microscopy), and FTIR (Fourier Transform Infrared Spectroscopy) tests on gold nanoparticles confirmed their synthesis. SEM and TEM images showed that the gold nanoparticles were spherical in shape with an average size of 22.89 nm. According to the results, the methanolic extract exhibited significantly higher antibacterial and antifungal activity compared to the aqueous extract, with the maximum inhibition zone diameters observed for Escherichia coli (14 mm) and Aspergillus niger (15 mm). Moreover, the antimicrobial activity of gold nanoparticles showed that these nanoparticles have relatively good ability to inhibit gram-negative bacteria, with the largest inhibition zone diameters observed for Escherichia coli (18 mm) and Aspergillus niger (20 mm). The antioxidant and reducing power activity (phenolic flavonoids content) of Halpeh plant extract treated with different concentrations of synthesized gold nanoparticles increased with increasing nanoparticle concentrations up to 60 ppm (IC50 = 9.94 µg/ml and reducing power = 16.85 mMFe2+/mg sample), and decreased at higher concentrations.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%