Gold nanoparticle-based optical nanosensors for food and health safety monitoring: recent advances and future perspectives

Abstract

We provide an overview of the synthesis of AuNPs and their excellent optical properties for the development of optical nanosensors including colorimetric, fluorescence resonance energy transfer, and surface-enhanced Raman scattering sensors.

Functional Micro-/Nanostructures in Agrofood Science: Precise Inspection, Hazard Elimination, and Potential Health Risks

“…The combination of Au@AgNPs and Raman technology has great potential for future applications in the detection of food hazards. Nonetheless, some oils and oil-soluble elements in complex food samples are likely to cause the rapid formation of AuNPs large aggregates and precipitates, which affects the intensity of the absorption spectrum and the accuracy of the detection results . Therefore, in the future optimization of AuNPs-based sensors, more attention should be paid to the antiaggregation stability of AuNPs, thus further improving the accuracy of sensor detection results.…”

Defect-rich graphene-coated metamaterial device for pesticide sensing in rice

“…To enhance the interaction between molecule and THz wave, the localized resonances excited by metamaterials which show an intense enhanced electromagnetic eld near the metallic structures are utilized. [17][18][19] However, THz metamaterial lakes in sensing selectivity 20 which limits its practical applications in detecting hazard molecules in a mixture. Taking advantage of the great biomolecular affinity via p-electrons, graphene has been utilized in chemical analyte detection, 21 aptamer sensing, 22 and uorescence transducing.…”

Nanotechnology meets immunology towards a rapid diagnosis solution: the COVID-19 outbreak challenge

“…9,13,14 In this view, the development of simple and rapid LFA-based diagnostic tests for the direct detection of SARS-CoV-2, abbreviating the usual time window necessary for conventional diagnostic methods associated with the potential utilization at the POC, is exceedingly needed as a crucial weapon to fight against the COVID-19 pandemic. 1,9,11,15,21–23…”

“…The continuous emergence of new pathogenic viruses, such as "Severe Acute Respiratory Syndrome Coronaviruses" (SARS-CoV), the "Middle East Respiratory Syndrome Coronavirus" (MERS-CoV), and more recently, the COVID-19 ("Coronavirus Disease of 2019") outbreak, have been seriously jeopardizing human health for centuries. In particular, the COVID-19 pandemic has been causing an immense impact on global society 1 for more than 2 years, posing unprecedented challenges to humanity.…”

“…9,13,14 In this view, the development of simple and rapid LFA-based diagnostic tests for the direct detection of SARS-CoV-2, abbreviating the usual time window necessary for conventional diagnostic methods associated with the potential utilization at the POC, is exceedingly needed as a crucial weapon to ght against the COVID-19 pandemic. 1,9,11,15,[21][22][23] Herein, we present all stages of the development of an LFAbased diagnostic immunoassay for directly detecting SARS-CoV-2, encompassing the in silico design of novel synthetic peptides with immunogenic epitopes inspired by the virus spike-protein, the production of high-affinity antibodies through semi-puried hyperimmune sera from rabbits, the synthesis of colloidal gold nanoparticles as optically active nanoprobes, their bioconjugation with the affinity biomolecules, which were all integrated into a nitrocellulose membrane strip, demonstrating effective recognition of COVID-19-infected patient sera.…”