Gold nanoparticle-based signal amplification for biosensing

Colorimetric Method for the Detection of Mercury Ions Based on Gold Nanoparticles and Mercaptophenyl Boronic Acid

“…Recently, Au NPs have been widely employed in developing biosensing systems for the detection of proteins, 30 sequencespecific DNA 31 and small molecules, 32 because of their unique properties such as facile synthesis, large specific surface area, high chemical stability and biocompatibility. The major advantages of using Au NPs for the detection of Hg 2+ ion include the elimination of the labeling process and the high sensitivity afforded arising from the extremely high extinction coefficients of their surface plasmon resonance (SPR) absorption effects.…”

Nonenzymatic Electrochemical Immunosensor Using Ferroferric Oxide–Manganese Dioxide–Reduced Graphene Oxide Nanocomposite as Label for α-Fetoprotein Detection

“…25 Au NPs have been widely applied in the fabrication of electrochemical biosensors owing to their high surface-to-volume ratio, fast electron transfer rate, strong adsorption ability and good biocompatibility. 26,27 Electrodeposition method is one of the most useful approaches to prepare gold nanostructures. 28 Thereby, ERGO-MWCNTs/Au NPs are considered as perfect platform materials for immunosensors.…”

Antibody-Conjugated Gold Nanoparticle-Based Immunosensor for Ultra-Sensitive Detection of Troponin-T

“…6 Because this biologically inert material does not affect molecular structure or activity, gold nanoparticles can be easily functionalized with biological macromolecules to allow for detection using a variety of optical and electrochemical transduction mechanisms. 7 Another beneficial characteristic of nanoparticles is the large surface area of their structure relative to their volume. This feature creates additional area that may allow for a greater number of reactions to occur at the surface of the material.…”

“…So far, these technologies are still limited in their applicability for lab-on-achip diagnostics, due to lengthy, complex setups that hinder it from being integrated as a valuable diagnostic tool. 7,8 The platform described here aims to resolve some of these issues through a method of microcontact printing using an elastomeric polydimethylsiloxane (PDMS) stamp. Microcontact printing has been used extensively for soft lithographic applications, where the molded relief on the stamp imprints a self-assembled monolayer (SAM) in a patterned fashion on the substrate.…”