Gold nanoparticle trapping and delivery for therapeutic applications

Aziz, M. S.; Suwanpayak, N.; Jalil, M. A.; Jomtarak, Rangsan; Saktioto, Saktioto; Ali, Jalil; Yupapin, Preecha P.

doi:10.2147/ijn.s27417

Cited by 14 publications

(4 citation statements)

References 38 publications

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“…Therefore, GNRs are suitable for photothermal agents in localized NIRinduced hyperthermia [12,[14][15][16]. Consequently the handling and manipulation of GNRs becomes an interesting and important topic, which offers great opportunities for targeted nanoscale drug delivery [17][18][19][20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Self-assisted optothermal trapping of gold nanorods under two-photon excitation

Chen

Gratton

Digman

2016

Methods Appl. Fluoresc.

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We report a self-assisted optothermal trapping and patterning of gold nanorods (GNRs) on glass surfaces with a femtosecond laser. We show that GNRs are not only the trapping targets, but also can enhance the optothermal trapping of other particles. This trapping phenomenon is the net result of thermophoresis and a convective flow caused by localized heating. The heating is due to the conversion of absorbed photons into heat at GNR’s longitudinal surface plasmon resonance (LSPR) wavelength. First, we investigated the optothermal trapping of GNRs at their LSPR wavelength on the glass surface with as low as 0.5 mW laser power. The trapping range was observed to be larger than a typical field of view, e.g. 210 μm × 210 μm here. Second, by adjusting the distance between the laser focus and the glass surface, ring patterns of GNRs on the glass surface were obtained. These patterns could be controlled by the laser power and the numerical aperture of the microscope objective. Moreover, we examined the spectral emission of GNRs under different trapping conditions using the spectral phasor approach to reveal the temperature and association status of GNRs. Our study will help understanding manipulation of flows in solution and in biological systems that can be applied in future investigations of GNR-induced heating and flows.

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Section: Introductionmentioning

confidence: 99%

Self-assisted optothermal trapping of gold nanorods under two-photon excitation

Chen

Gratton

Digman

2016

Methods Appl. Fluoresc.

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“…GNPs have been studied as sensitizers not only for radiotherapy but also for various other treatments, including thermal therapy 69 and chemotherapy. 70 Therefore, various GNP-mediated targeting and drug delivery methodologies have become available [71][72][73][74][75] and some of them are routinely used in laboratories. 76,77 The Zn@Au NPs that we developed have the same external structure as spherical GNPs and therefore have the potential to be used with the existing GNPmediated targeting methodologies.…”

Section: Discussionmentioning

confidence: 99%

Development of bimetallic (Zn@Au) nanoparticles as potential PET-imageable radiosensitizers

et al. 2016

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Purpose: Gold nanoparticles (GNPs) are being investigated actively for various applications in cancer diagnosis and therapy. As an effort to improve the imaging of GNPs in vivo, the authors developed bimetallic hybrid Zn@Au NPs with zinc cores and gold shells, aiming to render them in vivo visibility through positron emission tomography (PET) after the proton activation of the zinc core as well as capability to induce radiosensitization through the secondary electrons produced from the gold shell when irradiated by various radiation sources. Methods: Nearly spherical zinc NPs (∼5-nm diameter) were synthesized and then coated with a ∼4.25-nm gold layer to make Zn@Au NPs (∼13.5-nm total diameter). 28.6 mg of these Zn@Au NPs was deposited (∼100 µm thick) on a thin cellulose target and placed in an aluminum target holder and subsequently irradiated with 14.15-MeV protons from a GE PETtrace cyclotron with 5-µA current for 5 min. After irradiation, the cellulose matrix with the NPs was placed in a dose calibrator to assess the induced radioactivity. The same procedure was repeated with 8-MeV protons. Gamma ray spectroscopy using an high-purity germanium detector was conducted on a very small fraction (<1 mg) of the irradiated NPs for each proton energy. In addition to experimental measurements, Monte Carlo simulations were also performed with radioactive Zn@Au NPs and solid GNPs of the same size irradiated with 160-MeV protons and 250-kVp x-rays. Results: The authors measured 168 µCi of activity 32 min after the end of bombardment for the 14.15-MeV proton energy sample using the 66 Ga setting on a dose calibrator; activity decreased to 2 µCi over a 24-h period. For the 8-MeV proton energy sample, PET imaging was additionally performed for 5 min after a 12-h delay. A 12-h gamma ray spectrum showed strong peaks at 511 keV (2.05 × 10 6 counts) with several other peaks of smaller magnitude for each proton energy sample. PET imaging showed strong PET signals from mostly decaying 66 Ga. The Monte Carlo results showed that radioactive Zn@Au NPs and solid GNPs provided similar characteristics in terms of their secondary electron spectra when irradiated. Conclusions: The Zn@Au NPs developed in this investigation have the potential to be used as PET-imageable radiosensitizers for radiotherapy applications as well as PET tracers for molecular imaging applications. C

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“…Fraction of light that continues to propagate in its original direction is called the transmission coefficient and it is given by 𝑦 𝑖 = √1 −  𝑖 . Vice versa, the other fraction which travels across the waveguide (coupled to the second waveguide) is called cross-coupling coefficient denoted by 𝑗√ [24,25]. Transmission for one complete roundtrip of light propagation in ring resonator is derived using z-transform method and given it is by ξ=ɑz^(-1) [26].…”

Section: Operating Principlementioning

confidence: 99%

Theoretical Study on Slow-Light Generated by Integrated Microring Resonator With Wide Bandwidth and High Gain

et al. 2016

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We proposed a new approach to generate slow light transmission with large bandwidth and high buildup factor by using a soliton pulse propagating within integrated ring resonator circuit. The system consisted series of micron-size ring resonator fabricated by using nonlinear InGaAsP/InP material that are laterally coupled together. For convenience of analysis, optical transfer function for this model is obtained by using z-transform method. Slow light performances were modeled and discuss in this paper. Intensity buildup induced within the series of rings located at left and right sides of the system while strong nonlinear Kerr effect and mutual coupling leads to the spreading frequency bands within the device. Numerical simulation verifies that signal pulse with 45 ps relative delay time and bandwidth of 5.9 GHz (47 pm) are obtained at the communication wavelength around 1550 nm for a 100 ps signal pulse.

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Gold nanoparticle trapping and delivery for therapeutic applications

Cited by 14 publications

References 38 publications

Self-assisted optothermal trapping of gold nanorods under two-photon excitation

Self-assisted optothermal trapping of gold nanorods under two-photon excitation

Development of bimetallic (Zn@Au) nanoparticles as potential PET-imageable radiosensitizers

Theoretical Study on Slow-Light Generated by Integrated Microring Resonator With Wide Bandwidth and High Gain

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