Gold nanoparticles: A paradigm shift in biomedical applications

Khan, Muhammad Suleman; Vishakante, Gowda D.; Hatna, Siddaramaiah

doi:10.1016/j.cis.2013.06.003

Cited by 159 publications

(92 citation statements)

References 186 publications

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“…Recently, the synthesis of gold nanoparticles of size 2 -20 nm is proposed via the reduction of HAuCl 4 with sodium borohydride by using ethanol and isopropanol in the presence of tris(2-aminoethyl) amine [33].…”

Section: Chemical Methodsmentioning

confidence: 99%

Gold Nanoparticles: Synthesis and Applications in Drug Delivery

Ak¹,

Rashid²,

Murtaza³

et al. 2014

Trop. J. Pharm Res

386

163

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This review is focused essentially on the synthesis and applications of gold nanoparticles in the field of medicine and targeted drug delivery. Nanotechnology has become one of the most interesting and advanced areas of research in this field. Among nanoparticles, gold nanoparticles demonstrate special advantages in this field due to their unique properties, small size and high surface area-to-volume ratio.These particles have been widely used in various biomedical applications and drug delivery systems due to their inert nature, stability, high dispersity, non-cytotoxicity and biocompatibility.

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Section: Chemical Methodsmentioning

confidence: 99%

Gold Nanoparticles: Synthesis and Applications in Drug Delivery

Ak¹,

Rashid²,

Murtaza³

et al. 2014

Trop. J. Pharm Res

386

163

View full text Add to dashboard Cite

show abstract

“…Nanoconstructs may be in the form of nanocrystals, nanoparticles (polymeric or lipid or metallic), and any self-assemblage system of nanosized carrier for drug, vaccine, or genetic material (1)(2)(3)(4). Last three decades have witnessed exponential progress in the drug delivery research using such nanoconstructs.…”

Section: Introductionmentioning

confidence: 99%

Nanomedicine Scale-up Technologies: Feasibilities and Challenges

Babu²,

2014

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Abstract. Nanomedicine refers to biomedical and pharmaceutical applications of nanosized cargos of drugs/vaccine/DNA therapeutics including nanoparticles, nanoclusters, and nanospheres. Such particles have unique characteristics related to their size, surface, drug loading, and targeting potential. They are widely used to combat disease by controlled delivery of bioactive(s) or for diagnosis of life-threatening problems in their very early stage. The bioactive agent can be combined with a diagnostic agent in a nanodevice for theragnostic applications. However, the formulation scientist faces numerous challenges related to their development, scale-up feasibilities, regulatory aspects, and commercialization. This article reviews recent progress in the method of development of nanoparticles with a focus on polymeric and lipid nanoparticles, their scale-up techniques, and challenges in their commercialization.

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“…All of them are ideal candidates for cancer theranostic as well as gold nanorods due to their remarkable sets of optical, chemical and physical properties. 62 On the other hand, altering the size and shape of AuNPs to form anisotropic structures can easily tune their localized surface plasmon resonance (LSPR) to the transparent window of soft tissues in the NIR region. Hence, di®erent sizes and shapes of AuNPs provide various photothermal destruction during cancer treatment.…”

Section: Size and Shape Of Gold Nanoparticlementioning

confidence: 99%

Gold nanoparticles for cancer theranostics — A brief update

Zhao

Pan

Cheng

et al. 2016

J. Innov. Opt. Health Sci.

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Gold nanoparticles (AuNPs) exhibit superior optical and physical properties for more e®ective treatment of cancer through incorporating both diagnostic and therapeutic functions into one single platform. The ability to passively accumulate on tumor cells provides AuNPs the opportunity to become an attractive contrast agent for X-ray based computed tomography (CT) imaging in vivo. Because of facile surface modi¯cation, various size and shape of AuNPs have been extensively functionalized and applied as active nanoprobes and drug carriers for cancer targeted theranostics. Moreover, their capabilities on producing photoacoustic (PA) signals and photothermal e®ects have been used to image and treat tumor progression, respectively. Herein, we review the developments of AuNPs as cancer diagnostics and chemotherapeutic drug vector, summarizing strategies for tumor targeting and their applications in vitro and in vivo.

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Gold nanoparticles: A paradigm shift in biomedical applications

Cited by 159 publications

References 186 publications

Gold Nanoparticles: Synthesis and Applications in Drug Delivery

Gold Nanoparticles: Synthesis and Applications in Drug Delivery

Nanomedicine Scale-up Technologies: Feasibilities and Challenges

Gold nanoparticles for cancer theranostics — A brief update

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